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1.13.11.34: arachidonate 5-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 5-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.34

Reaction

(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
=
leukotriene A4
+
H2O

Synonyms

5-lipoxygenase, 5-LO, 5-LO1, 5-LOX, 5DELTA-lipoxygenase, 5LO, 5LOX-1, ALOX5, arachidonate 5-LO, arachidonate:oxygen oxidoreductase, arachidonic 5-lipoxygenase, arachidonic acid 5-lipoxygenase, C-5-lipoxygenase, DELTA5-lipoxygenase, H5-LO, leukotriene A4 synthase, leukotriene-A4 synthase, lipoxygenase 15, lipoxygenase 5, lipoxygenase-1, LO-1, LOX-15, LOX-5, LTA synthase, LTA4 synthase, oxygenase, arachidonate, 5-lip-, PMNL 5-lipoxygenase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.34 arachidonate 5-lipoxygenase

Storage Stability

Storage Stability on EC 1.13.11.34 - arachidonate 5-lipoxygenase

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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, 40 mM potassium phosphate buffer, pH 6.3, 2 M (NH4)2SO4, enzyme form L1 is stable for months
-
-20°C, stable for weeks
-
-70°C, 1 month, 50% loss of activity
-
-70°C, 1 week, no appreciable inactivation
-
-70°C, appreciable loss of activity after several weeks
-
0-4°C, 24 h, loss of more than half of its activity
0-4°C, 30 min, 40-60% loss of activity
-
0°C, 30 h, about 70% loss of activity, in presence of 2 mM ATP only 30% loss of activity
-
4°C, 48 h, no appreciable loss of activity
-
4°C, stable for days
-
4°C, the L1 form is gradually transformed into the L2 form with a significant reduction in specific activity, the L2 form loses all of its activity over a few days and more rapid in absence of (NH4)2SO4
-