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1.13.11.34: arachidonate 5-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 5-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.34

Reaction

(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
=
leukotriene A4
 +
H2O

Synonyms

5-lipoxygenase, 5-LO, 5-LO1, 5-LOX, 5DELTA-lipoxygenase, 5LO, 5LOX-1, ALOX5, arachidonate 5-LO, arachidonate:oxygen oxidoreductase, arachidonic 5-lipoxygenase, arachidonic acid 5-lipoxygenase, C-5-lipoxygenase, DELTA5-lipoxygenase, H5-LO, leukotriene A4 synthase, leukotriene-A4 synthase, lipoxygenase 15, lipoxygenase 5, lipoxygenase-1, LO-1, LOX-15, LOX-5, LTA synthase, LTA4 synthase, oxygenase, arachidonate, 5-lip-, PMNL 5-lipoxygenase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.34 arachidonate 5-lipoxygenase

Source Tissue

Source Tissue on EC 1.13.11.34 - arachidonate 5-lipoxygenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
induced by a Ca2+ ionophore, from acute myeloid leukemic and acute lymphoid leukemic patients, upregulation of the enzyme, quantitative expression analysis
Manually annotated by BRENDA team
-
expression is not significantly different between diabetic and control rats. Activation of the 5-lipoxygenase previously reported in streptozotocin-induced diabetic rats can be explained by an augmented sensitivity to cysteinyl leukotrienes in the diabetic aorta
Manually annotated by BRENDA team
-
in healthy animals, 5-LOX expression is almost exclusively limited to the bronchiolar epithelial cells, while Metastrongylus spp.-parasitized pigs have greater 5-LOX-specific immunoreactivity involving a wide range of cell types within foci of granulomatous and eosinophilic bronchopneumonia
Manually annotated by BRENDA team
-
osteoarthritic chondrocyte
Manually annotated by BRENDA team
-
high enzyme expression level
Manually annotated by BRENDA team
-
high enzyme expression level
Manually annotated by BRENDA team
-
normal skin keratinocytes and a cell line of human keratinocytes, HaCaT
Manually annotated by BRENDA team
high expression level. In the kidney, the expression levels of Alox5 of fish fed diets with low dietary linolenic acid/linoleic acid (0.03-0.06) are significantly higher than those of fish fed diets with high dietary linolenic acid/linoleic acid (0.45-1.51)
Manually annotated by BRENDA team
-
high enzyme expression level
Manually annotated by BRENDA team
low expression level
Manually annotated by BRENDA team
-
from peripheral venous blood
Manually annotated by BRENDA team
-
ungerminated
Manually annotated by BRENDA team
-
high expression of 5-lipoxygenase in mantle zone B cells from tonsils, weak expression in germinal centre cells and no expression in plasma cells from tonsils. High expression in mantle B cell lymphoma and weak or no expression in follicular lymphoma. Primary leukemized mantle B cell lymphoma (B-prolymphocytic leukaemia cells) and mantle B cell lymphoma cell lines also expressed 5-lipoxygenase
Manually annotated by BRENDA team
-
5-lipoxygenase/cyclooxygenase-2 cross-talk through cysteinyl leukotriene receptor 2 in endothelial cells, overview
Manually annotated by BRENDA team
additional information