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1.13.11.34: arachidonate 5-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 5-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.34

Reaction

(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
=
leukotriene A4
+
H2O

Synonyms

5-lipoxygenase, 5-LO, 5-LO1, 5-LOX, 5DELTA-lipoxygenase, 5LO, 5LOX-1, ALOX5, arachidonate 5-LO, arachidonate:oxygen oxidoreductase, arachidonic 5-lipoxygenase, arachidonic acid 5-lipoxygenase, C-5-lipoxygenase, DELTA5-lipoxygenase, H5-LO, leukotriene A4 synthase, leukotriene-A4 synthase, lipoxygenase 15, lipoxygenase 5, lipoxygenase-1, LO-1, LOX-15, LOX-5, LTA synthase, LTA4 synthase, oxygenase, arachidonate, 5-lip-, PMNL 5-lipoxygenase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.34 arachidonate 5-lipoxygenase

Expression

Expression on EC 1.13.11.34 - arachidonate 5-lipoxygenase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
0.01 mM hydroxynonenal induces 5-LOX promoter activity significantly by 310% and 580% after 48 and 72 h of incubation, respectively. The addition of anti-transforming growth factor-beta1 antibody reduces hydroxynonenal-induced 5-LOX expression by 40%
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5-LOX activity is quantitatively similar in normal versus Metastrongylus spp.-parasitized lung tissue samples
-
aberrant methylation may lead to upregulated 5-lipoxygenase expression in tumor cells. The 5-lipoxygenase core promoter is completely methylated in cell lines U-937 and HL-60TB, which do not express 5-lipoxygenase. Treatment with the demethylating agent 5-aza-2'deoxycytidine restores 5-lipoxygenase expression
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coexpression of the truncated natural isoforms inhibits or stimulates 5-LO-wild-type expression in transiently and stably transfected HEK-293T cells suggesting that the isoforms have other functions than canonical leukotriene biosynthesis
DNA methylation is responsible for suppression of 5-lipoxygenase expression in most cell types
-
in the liver, the Alox5 mRNA expression levels significantly increase to the maximum when the dietary linolenic acid/linoleic acid increases from 0.03 to 0.06, and then significantly decreases with dietary linolenic acid/linoleic acid increased to 1.51. In the kidney, the expression levels of Alox5 of fish fed diets with low dietary linolenic acid/linoleic acid (0.03-0.06) are significantly higher than those of fish fed diets with high dietary linolenic acid/linoleic acid (0.45-1.51)
methyl-DNA binding proteins MBD1, MBD2 and MeCP2 downregulate 5-LO mRNA expression in U-937 cells
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stimulation of J774A.1 cells with 0.01 mM acrolein for 4-24 h leads to increased 5-LO expression through activation of the ERK pathway. Acrolein-induced 5-LO expression is inhibited in a dose-dependent manner by pretreatment with AG1478, but not by pretreatment with AG1295
-