1.13.11.33: arachidonate 15-lipoxygenase

0.033

(-)-5,7-O-dibutyryl-3',4',5'-O-tributyrylepigallocatechin-3-O-(3'',4'',5''-O-tributyryl) gallate

Oryctolagus cuniculus

IC50: 0.033 mM

0.03

(-)-5,7-O-dimethyl-3',4',5'-O-trimethylepigallocatechin-3-O-(3'',4'',5''-O-trimethyl) gallate

Oryctolagus cuniculus

IC50: 0.03 mM

0.031

(-)-5,7-O-dipropionyl-3',4',5'-O-tripropionylepigallocatechin-3-O-(3'',4'',5''-O-tripropionyl) gallate

Oryctolagus cuniculus

IC50: 0.031 mM

0.1

(-)-epigallocatechin-3-gallate

Oryctolagus cuniculus

IC50: 0.1 mM

0.0014

(-)-jaspic acid

Oryctolagus cuniculus

IC50: 0.0014 mM

0.028

1,2,3-triphenylindolizine-7-carbonitrile

Glycine max

IC50: 0.028 mM

0.017

1-(((2,4,6-trimethylphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.017 mM

0.027

1-(((2,4-dimethoxyphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.027 mM

0.015

1-(((2,5-dimethoxyphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.015 mM

0.042

1-(((2-methyl)ethylsulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.042 mM

0.022

1-(((2-methyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.022 mM

0.021

1-(((2-thienyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.021 mM

0.019

1-(((3,4-dimethoxyphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.019 mM

0.023

1-(((3-thienyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.023 mM

0.016

1-(((4-(2-methylethyl)phenl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.016 mM

0.022

1-(((4-chlorophenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.022 mM

0.025

1-(((4-methoxyphenyl)sulfonyl)oxy)-2,3-bis(4-methylphenyl)-7-indolizinecarbonitrile

Glycine max

IC50: 0.025 mM

0.025

1-(((4-methoxyphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.025 mM

0.2

1-(((4-methylphenyl)sulfonyl)oxy)-2,3-bis(4-chlorophenyl)-7-indolizinecarbonitrile

Glycine max

IC50: 0.2 mM

0.22

1-(((4-methylphenyl)sulfonyl)oxy)-2,3-bis(4-fluorophenyl)-7-indolizinecarbonitrile

Glycine max

IC50: 0.22 mM

0.024

1-(((4-methylphenyl)sulfonyl)oxy)-2,3-bis(4-methoxyphenyl)-7-indolizinecarbonitrile

Glycine max

IC50: 0.024 mM

0.2

1-(((4-methylphenyl)sulfonyl)oxy)-2,3-bis(4-methylphenyl)-7-indolizinecarbonitrile

Glycine max

IC50: 0.2 mM

0.03

1-(((4-methylphenyl)sulfonyl)oxy)-2,3-dibutyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.03 mM

0.029

1-(((4-methylphenyl)sulfonyl)oxy)-2,3-diethyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.029 mM

0.02

1-(((4-methylphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarboxaldehyde

Glycine max

IC50: 0.02 mM

0.023

1-(((4-methylphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinylethanone

Glycine max

IC50: 0.023 mM

0.024

1-(((4-methysulfonyllphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.024 mM

0.023

1-(((4-trifluoromethylphenyl)sulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.023 mM

0.029

1-((4-methylphenyl)sulfonyl)2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.029 mM

0.028

1-((butylsulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.028 mM

0.022

1-((methylsulfonyl)oxy)-2,3-diphenyl-7-indolizine-carbonitrile

Glycine max

IC50: 0.022 mM

0.025

1-((N,N-dimethylaminosulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.025 mM

0.024

1-((phenylsulfonyl)oxy)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.024 mM

0.031

1-(1,3-dibenzyloxy-2-propyloxy)methoxy-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.031 mM

0.017

1-(1-Hydroxy-1-phenyl-ethyl)-2,3-diphenyl-indolizine-7-carbonitrile

Glycine max

IC50: 0.017 mM

0.026

1-(1-hydroxyethyl)-2,3-diphenylindolizine-7-carbonitrile

Glycine max

IC50: 0.026 mM

0.024

1-(2-furyl)-2,3-diphenylindolizine-7-carbonitrile

Glycine max

IC50: 0.024 mM

0.02

1-(2-Methoxy-phenyl)-2,3-diphenyl-indolizine-7-carbonitrile

Glycine max

IC50: 0.02 mM

0.029

1-(2-methoxyphenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.029 mM

0.031

1-(3-chlorophenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.031 mM

0.02

1-(3-Methoxy-phenyl)-2,3-diphenyl-indolizine-7-carbonitrile

Glycine max

IC50: 0.02 mM

0.031

1-(4-chlorophenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.031 mM

0.035

1-(4-fluorophenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.035 mM

0.02 - 0.037

1-(4-Methoxy-phenyl)-2,3-diphenyl-indolizine-7-carbonitrile

0.032

1-(4-methoxyphenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.032 mM

0.037

1-(4-methylphenyl)methoxy-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.037 mM

0.0101

1-(4-tert-butylphenyl)-4-[4-(diphenylmethoxy)piperidin-1-yl]butan-1-one

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.023

1-(Cyclohexyl-hydroxy-methyl)-2,3-diphenyl-indolizine-7-carbonitrile

Glycine max

IC50: 0.023 mM

0.022

1-(Hydroxy-p-tolyl-methyl)-2,3-diphenyl-indolizine-7-carbonitrile

Glycine max

IC50: 0.022 mM

0.035 - 0.048

1-(Hydroxy-phenyl-methyl)-2,3-diphenyl-indolizine-7-carbonitrile

0.026

1-(hydroxymethyl)-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.026 mM

0.034

1-(hydroxymethyl)-2,3-diphenylindolizine-7-carbonitrile

Oryctolagus cuniculus

IC50: 0.034 mM

0.021

1-(Methoxy-phenyl-methyl)-2,3-diphenyl-indolizine-7-carbonitrile

Glycine max

IC50: 0.021 mM

0.031 - 0.075

1-(methoxymethoxy)-2,3-diphenylindolizine-7-carbonitrile

0.023 - 0.044

1-acetyl-2,3-diphenylindolizine-7-carbonitrile

0.023 - 0.043

1-benzoyl-2,3-diphenylindolizine-7-carbonitrile

0.027

1-benzyl-2,3-diphenylindolizine-7-carbonitrile

Glycine max

IC50: 0.027 mM

0.027 - 0.039

1-benzyloxymethoxy-2,3-diphenyl-7-indolizinecarbonitrile

0.029 - 0.061

1-formyl-2,3-diphenylindolizine-7-carbonitrile

0.033 - 0.077

1-methoxy-2,3-diphenylindolizine-7-carbonitrile

0.027 - 0.046

1-methyl-2,3-diphenylindolizine-7-carbonitrile

0.00034

1-phenyl-2-([[4-(trifluoromethyl)phenyl]methyl]sulfanyl)-1H-imidazole

Homo sapiens

pH 7.5, 23°C

0.031

1-phenylmethoxy-2,3-diphenyl-7-indolizinecarbonitrile

Glycine max

IC50: 0.031 mM

0.023

1-[(4-Chloro-phenyl)-hydroxy-methyl]-2,3-diphenyl-indolizine-7-carbonitrile

Glycine max

IC50: 0.023 mM

0.0058

1-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.008

1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.046

1-[4-[4-([[5-(3-chlorophenyl)furan-2-yl]methyl]amino)phenyl]piperazin-1-yl]ethan-1-one

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.0045

1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.017

1-[Hydroxy-(4-methoxy-phenyl)-methyl]-2,3-diphenyl-indolizine-7-carbonitrile

Glycine max

IC50: 0.017 mM

0.071

11-hydroxytephrosin

Sarcolobus globosus

IC50: 0.071 mM

0.018

12alpha-hydroxydeguelin

Sarcolobus globosus

IC50: 0.018 mM

0.102

12alpha-hydroxyrotenone

Sarcolobus globosus

IC50: 0.102 mM

0.0018 - 0.007

2,3,4,5-tetrabromo-6-(2,4-dibromophenoxy)phenol

0.00079

2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxyphenoxy)phenol

Homo sapiens

IC50: 0.00079 mM

0.0022

2,3,5-tribromo-6-(3,5-dibromo-2-hydroxyphenoxy)phenol

Homo sapiens

IC50: 0.0022 mM

0.033

2,3-bis(4-chlorophenyl)-7-indolizinecarbonitrile

Glycine max

IC50: 0.033 mM

0.03

2,3-bis(4-fluorophenyl)-7-indolizinecarbonitrile

Glycine max

IC50: 0.03 mM

0.027

2,3-bis(4-methylphenyl)-7-indolizinecarbonitrile

Glycine max

IC50: 0.027 mM

0.02

2,3-diphenyl-1-(2-thienyl)indolizine-7-carbonitrile

Glycine max

IC50: 0.02 mM

0.019

2,3-diphenyl-1-(3-thienyl)indolizine-7-carbonitrile

Glycine max

IC50: 0.019 mM

0.025

2,3-diphenyl-1-indolizinol tosylate

Glycine max

IC50: 0.025 mM

0.03 - 0.051

2,3-diphenylindolizine-7-carbonitrile

0.01

2,4-dibromo-6-(2,4-dibromo-6-methoxyphenoxy)phenol

Homo sapiens

IC50: 0.01 mM

0.034

2,4-Dibromophenol

Homo sapiens

IC50: 0.034 mM

0.005

2,6-dibromo-4-[1-(3-bromo-4-hydroxyphenyl)-1-methylethyl]phenol

Homo sapiens

IC50: 0.005 mM

0.0026 - 0.078

2-(4-chlorophenyl)-5-cyclohexyl-1,3,4-oxadiazole

0.034

2-(4-ethylpiperazin-1-yl)4-methylpyrimido[4,5-b][1,4]benzothiazine

Glycine max

pH 9.0, 20°C

685512

0.235

2-(4-ethylpiperazin-1-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

pH 9.0, 20°C

0.267

2-(4-methylpiperazin-1-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

pH 9.0, 20°C

0.18

2-(4-methylpiperidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

pH 9.0, 20°C

0.14

2-(morpholin-4-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

pH 9.0, 20°C

0.146

2-(piperidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

pH 9.0, 20°C

0.216

2-(pyrrolidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

pH 9.0, 20°C

0.0067

2-[4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy]-N,N-dimethylethan-1-amine

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.00053

2-[[(4-bromophenyl)methyl]sulfanyl]-1-phenyl-1H-imidazole

Homo sapiens

pH 7.5, 23°C

0.00087

2-[[(4-ethylphenyl)methyl]sulfanyl]-1-phenyl-1H-imidazole

Homo sapiens

pH 7.5, 23°C

0.0062

3'-chloro-7,8-dihydroxyisoflavone

Homo sapiens

pH 7.5, 22°C, isozyme 15-hLO-1

0.0021

3'-naphthalen-2-yl-1'-phenyl-5-p-tolyl-3,4-dihydro-1'H-[3,4']bipyrazolyl-2-carbothioic acid amide

Glycine max

pH 7.4, temperature not specified in the publication

0.0015

3'-naphthalen-2-yl-5,1'-diphenyl-3,4-dihydro-1'H-[3,4']bipyrazolyl-2-carbothioic acid amide

Glycine max

pH 7.4, temperature not specified in the publication

0.00223

3'-naphthalen-2-yl-5,1'-diphenyl-3,4-dihydro-2H,1'H-[3,4']bipyrazole

Glycine max

pH 7.4, temperature not specified in the publication

0.0009

3,4,6,8-tetrabromooxanthren-1-ol

Homo sapiens

IC50: 0.0009 mM

0.005 - 0.009

3,4,6-tribromo-2-(2,4-dibromophenoxy)phenol

0.011

3,4-dibromo-2-(5-bromo-2-hydroxyphenoxy)phenol

Homo sapiens

IC50: 0.011 mM

0.015 - 0.05

3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

0.0008

3,6,8-tribromooxanthren-1-ol

Homo sapiens

IC50: 0.0008 mM

0.00437

3-(4-methoxyphenyl)-5-(3-naphthalen-2-yl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-1,2-oxazole

Glycine max

pH 7.4, temperature not specified in the publication

0.059

3-[3-bromo-5-(2,6-dibromo-4-{2-[2-(3-bromo-4-hydroxy-phenyl)-ethylcarbamoyl]-2-[(E)-hydroxyimino]-ethyl}-phenoxy)-4-methyl-phenyl]-N-[(E)-2-(3,5-dibromo-4-hydroxy-phenyl)-vinyl]-2-[(E)-hydroxyimino]-propionamide

0.0031

3-[[(4-methylphenyl)methyl]sulfanyl]-1-phenyl-1H-1,2,4-triazole

Homo sapiens

pH 7.5, 23°C

0.00051 - 0.071

4',6,7-trihydroxyisoflavan

0.0038 - 0.1

4',6,7-trihydroxyisoflavanone

0.049

4',6,7-trihydroxyisoflavone

Homo sapiens

pH 7.5, 22°C, isozyme 15-hLO-1

0.0002

4'-butyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide

Oryctolagus cuniculus

IC50: 0.00053 mM in the presence of arachidonate, IC50: 0.0002 mM in the presence of linoleic acid

0.009

4'-chloro-7,8-dihydroxyisoflavone

Homo sapiens

pH 7.5, 22°C, isozyme 15-hLO-1

0.00047

4'-ethyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide

Oryctolagus cuniculus

IC50: 0.00026 mM in the presence of arachidonate, IC50: 0.00047 mM in the presence of linoleic acid

0.00023

4'-tert-butyl-N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide

Oryctolagus cuniculus

IC50: 0.00027 mM in the presence of arachidonate, IC50: 0.00023 mM in the presence of linoleic acid

0.011

4,4'-(2,3-dimethylbutane-1,4-diyl)di(benzene-1,2-diol)

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.004

4,4'-propane-2,2-diylbis(2,6-dibromophenol)

Homo sapiens

IC50: 0.004 mM

0.062

4,5-bis(4-chlorophenyl)-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.0234

4,5-bis(4-fluorophenyl)-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.0147

4,5-bis(4-methoxyphenyl)-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.000032

4,5-dichloro-N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide

Homo sapiens

pH not specified in the publication, temperature not specified in the publication

0.0152

4,5-diphenyl-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.045 - 0.132

4-(2-chlorophenyl)-N-[2-[5-(4-methoxyphenyl)-2-thioformyl-1H-imidazol-4-yl]ethyl]piperazine-1-sulfonamide

0.0131

4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.055 - 0.378

4-(3,4-dichlorophenyl)-N-[2-[5-(4-methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]ethyl]piperazine-1-sulfonamide

0.036 - 0.133

4-(3,4-dichlorophenyl)-N-[2-[5-(4-methoxyphenyl)-2-thioformyl-1H-imidazol-4-yl]ethyl]piperazine-1-sulfonamide

0.0249

4-(4-chlorophenyl)-5-phenyl-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.0137

4-(4-methoxyphenyl)-5-phenyl-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.000017

4-allyl-2-methoxyphenyl 1-adamantanecarboxylate

Glycine max

0.0022

4-allyl-2-methoxyphenyl 1-cyclohexanecarboxylate

Glycine max

0.168

4-allyl-2-methoxyphenyl 2-chlorobenzoate

Glycine max

0.0067

4-allyl-2-methoxyphenyl 2-fluorobenzoate

Glycine max

0.0772

4-allyl-2-methoxyphenyl 2-methylbenzoate

Glycine max

0.0333

4-allyl-2-methoxyphenyl 2-pyridinecarboxylate

Glycine max

0.0052

4-allyl-2-methoxyphenyl 3-chlorobenzoate

Glycine max

0.0021

4-allyl-2-methoxyphenyl 3-fluorobenzoate

Glycine max

0.023

4-allyl-2-methoxyphenyl 3-methoxybenzoate

Glycine max

0.0114

4-allyl-2-methoxyphenyl 3-methylbenzoate

Glycine max

0.1343

4-allyl-2-methoxyphenyl 4-chlorobenzoate

Glycine max

0.0072

4-allyl-2-methoxyphenyl 4-fluorobenzoate

Glycine max

0.019

4-allyl-2-methoxyphenyl 4-methoxybenzoate

Glycine max

0.0146

4-allyl-2-methoxyphenyl 4-methylbenzoate

Glycine max

0.0044

4-allyl-2-methoxyphenyl benzoate

Glycine max

0.0023

4-allyl-2-methoxyphenyl isonicotinate

Glycine max

0.0017

4-allyl-2-methoxyphenyl nicotinate

Glycine max

0.048 - 0.055

4-Bromophenol

0.004

4-butyl-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide

Oryctolagus cuniculus

IC50: 0.00307 mM in the presence of arachidonate, IC50: 0.004 mM in the presence of linoleic acid

0.014 - 0.05

4-butyl-N-[2-[5-(4-methoxyphenyl)-2-thioformyl-1H-imidazol-4-yl]ethyl]piperazine-1-sulfonamide

0.01

4-ethyl-N-[2-(1H-indol-3-yl)ethyl]benzenesulfonamide

Oryctolagus cuniculus

IC50: 0.01 mM in the presence of arachidonate, IC50: 0.01 mM in the presence of linoleic acid

0.036

4-methyl-2-(4-ethylpiperazin-1-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

pH 9.0, 20°C

0.2

4-methyl-2-(4-hydroxypiperidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

above, pH 9.0, 20°C

685512

0.018

4-methyl-2-(4-methylpiperazin-1-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

pH 9.0, 20°C

0.0171

4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine

Homo sapiens

pH 7.0, 25°C

0.076

4-methyl-2-(4-methylpiperidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

pH 9.0, 20°C

0.2

4-methyl-2-(4-phenylpiperazin-1-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

above, pH 9.0, 20°C

685512

0.053 - 0.058

4-methyl-2-(morpholin-4-yl)pyrimido[4,5-b][1,4]benzothiazine

0.058

4-methyl-2-(piperidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

pH 9.0, 20°C

0.048

4-methyl-2-(pyrrolidin-1-yl)pyrimido[4,5-b][1,4]benzothiazine

Glycine max

pH 9.0, 20°C

0.0046

4-nitrocatechol

Oryctolagus cuniculus

IC50: 0.0046 mM

0.000072 - 0.000372

4-pentyl-N-(2-[2-phenyl-5-[4-(trifluoromethyl)phenyl]-1H-imidazol-4-yl]ethyl)benzenesulfonamide

0.01

4-pentyl-N-[2-(5-phenyl-1H-imidazol-4-yl)ethyl]benzenesulfonamide

Homo sapiens

above, versus substrate linoleic acid

0.00281

4-pentyl-N-[2-(5-phenyl-2-pyrazin-2-yl-1H-imidazol-4-yl)ethyl]benzenesulfonamide

Homo sapiens

versus substrate linoleic acid

0.00097 - 5.321

4-pentyl-N-[2-(5-phenyl-2-pyridin-2-yl-1H-imidazol-4-yl)ethyl]benzenesulfonamide

0.00056

4-pentyl-N-[2-(5-phenyl-2-pyridin-3-yl-1H-imidazol-4-yl)ethyl]benzenesulfonamide

Homo sapiens

versus substrate linoleic acid

0.000087 - 3.211

4-pentyl-N-[2-(5-phenyl-2-pyridin-4-yl-1H-imidazol-4-yl)ethyl]benzenesulfonamide

0.000006 - 0.000013

4-pentyl-N-[2-(5-phenyl-2-thioformyl-1H-imidazol-4-yl)ethyl]benzenesulfonamide

0.000053 - 0.000396

4-pentyl-N-[3-(5-phenyl-2-thioformyl-1H-imidazol-4-yl)propyl]benzenesulfonamide

0.00978

4-[(E)-benzoyldiazenyl]benzonitrile

Homo sapiens

pH and temperature not specified in the publication

742080

0.0094

4-[4-(dimethylamino)phenyl]-5-(4-methoxyphenyl)-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.0057

4-[4-(methylsulfanyl)phenyl]-5-phenyl-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.02

4-[[5-(naphthalen-1-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]but-2-yn-1-yl benzoate

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.00012

5,8,11,14-eicosatetraenoic acid

Oryctolagus cuniculus

IC50: 0.00012 mM

0.00157

5-(3,4-dichlorophenyl)-3'-naphthalen-2-yl-1'-phenyl-3,4-dihydro-1'H-[3,4']bipyrazolyl-2-carbothioic acid

Glycine max

pH 7.4, temperature not specified in the publication

0.00353

5-(3,4-dichlorophenyl)-3'-naphthalen-2-yl-2,1'-diphenyl-3,4-dihydro-2H,1'H-[3,4']-bipyrazole

Glycine max

pH 7.4, temperature not specified in the publication

0.00423

5-(3-naphthalen-2-yl-1-phenyl-1H-pyrazol-4-yl)-3-p-tolyl-4,5-dihydro-1,2-oxazole

Glycine max

pH 7.4, temperature not specified in the publication

0.0047

5-(4-chlorophenyl)-4-(4-methoxyphenyl)-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.25

5-(4-chlorophenyl)-4-(4-methoxyphenyl)-2-(methylsulfanyl)-1H-imidazole

Glycine max

value above, pH 7.0, temperature not specified in the publication

0.0223

5-(4-chlorophenyl)-4-[4-(dimethylamino)phenyl]-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.0197

5-(4-chlorophenyl)-4-[4-(methylsulfanyl)phenyl]-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.011

5-(4-fluorophenyl)-4-(4-methoxyphenyl)-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.136

5-(4-fluorophenyl)-4-[4-(methylsulfanyl)phenyl]-1H-imidazole-2-thiol

Glycine max

pH 7.0, temperature not specified in the publication

0.032 - 0.059

5-(methoxymethoxy)-6,7-diphenylpyrrolo[1,2-b]pyridazine

0.0002

5-(methylamino)-2-(naphthalen-1-yl)-4,5-dihydro-1,3-oxazole-4-carbonitrile

Homo sapiens

pH not specified in the publication, temperature not specified in the publication

0.00055

5-chloro-N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide

Homo sapiens

pH not specified in the publication, temperature not specified in the publication

0.028

5-ethoxy-6,7-diphenylpyrrolo[1,2-b]pyridazine

Glycine max

IC50: 0.028 mM

0.029 - 0.059

5-methoxy-6,7-diphenylpyrrolo[1,2-b]pyridazine

0.000197

6,6a,11,11a-tetrahydro[1]benzothiopyrano[4,3-b]indole

Homo sapiens

pH not specified in the publication, temperature not specified in the publication

0.018

6,7-dihydroxy-2-t-butylbenzopyran-4-one

Homo sapiens

pH 7.5, 22°C, isozyme 15-hLO-1

0.00035 - 0.016

6,7-dihydroxy-3',4'-methylenedioxyisoflavan

0.00021 - 0.0083

6,7-dihydroxy-3'-methylisoflavan

0.00021 - 0.014

6,7-dihydroxy-3'-methylisoflavanone

0.00015 - 0.1

6,7-dihydroxy-4'-methoxyisoflavan

0.0016 - 0.019

6,7-dihydroxy-4'-methoxyisoflavanone

0.137

6,7-dimethoxy-2,3-dihydrochromone

Sarcolobus globosus

IC50: 0.137 mM

0.015

6,7-diphenylpyrrolo[1,2-a]pyrimidin-8-ol tosylate

Glycine max

IC50: 0.015 mM

0.043

6,7-diphenylpyrrolo[1,2-b]pyridazin-5-yl trifluoromethanesulfonate

Glycine max

IC50: 0.043 mM

0.022

6,7-diphenylpyrrolo[1,2-c]pyrimidin-5-ol tosylate

Glycine max

IC50: 0.022 mM

0.038

6-hydroxy-2-pentyl-4H-benzopyran-4-one

Homo sapiens

pH 7.5, 22°C, isozyme 15-hLO-1

0.0114

6-[4-([1,1'-biphenyl]-2-yl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.062

6alpha,12alpha-12alpha-hydroxyelliptone

Sarcolobus globosus

IC50: 0.062 mM

0.071

6alpha,12alpha-dehydrodeguelin

Sarcolobus globosus

IC50: 0.071 mM

0.1

7,8-dihydroxy-3',4'-dimethoxyisoflavan

0.011

7,8-dihydroxy-3'-methylisoflavone

Homo sapiens

pH 7.5, 22°C, isozyme 15-hLO-1

0.0083

7,8-dihydroxy-3'-trifluoromethylisoflavone

Homo sapiens

pH 7.5, 22°C, isozyme 15-hLO-1

0.0037 - 0.1

7,8-dihydroxy-4'-methoxyisoflavan

0.0057 - 0.1

7,8-dihydroxy-4'-methylisoflavan

0.0078

7,8-dihydroxy-4'-methylisoflavone

Homo sapiens

pH 7.5, 22°C, isozyme 15-hLO-1

0.013

7,8-dihydroxyisoflavone

Homo sapiens

pH 7.5, 22°C, isozyme 15-hLO-1

0.022

7-(1,1-dimethylethyl)-2,3-diphenyl-1-indolizinol tosylate

Glycine max

IC50: 0.022 mM

0.03

7-cyano-2,3-diphenylindolizin-1-yl 2-methoxybenzoate

Glycine max

IC50: 0.03 mM

0.028

7-cyano-2,3-diphenylindolizin-1-yl 3-methoxybenzoate

Glycine max

IC50: 0.028 mM

0.028

7-cyano-2,3-diphenylindolizin-1-yl 4-methoxybenzoate

Glycine max

IC50: 0.028 mM

0.046 - 0.059

7-cyano-2,3-diphenylindolizin-1-yl trifluoromethanesulfonate

0.0162

7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.0041

8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.0006 - 0.003

ABT-384

0.0261

adamantyl caffeate

Homo sapiens

pH 7.0, 25°C

0.0031 - 0.05

alpha-mangostin

0.0003 - 100

apigenin

0.001 - 100

baicalein

0.063

barbigerone

Sarcolobus globosus

IC50: 0.063 mM

0.027

bestatin

Glycine max

IC50: 0.027 mM

0.027

bestatin 7

Homo sapiens

IC50: 0.027 mM

0.399

bornyl vanillate

Homo sapiens

pH 7.0, 25°C

chrysin

Oryctolagus cuniculus

IC50: 1 mM

0.25 - 0.43

daidzein

0.00373

dansyl tryptamine

Oryctolagus cuniculus

IC50: 0.00373 mM

0.00006

ebselen

Oryctolagus cuniculus

i.e. 2-phenyl-1,2-benzisoselenazol-3(2H)-one, irreversible inhibition, IC50: 0.00006 mM

0.06

epicatechin

Oryctolagus cuniculus

IC50: 0.06 mM

0.00009

ethyl 6-chloro-3-[(3S)-3-hydroxy-7-methyloctanoyl]-2,3-dihydro-1H-indole-2-carboxylate

Homo sapiens

pH not specified in the publication, temperature not specified in the publication

0.011

fenchyl caffeate

Homo sapiens

pH 7.0, 25°C

0.0018 - 0.0035

fisetin

0.32 - 0.7

flavone

0.045 - 0.2

galangin

0.018 - 1

genistein

0.167

genistin

Sarcolobus globosus

IC50: above 0.167 mM

0.167

glucosyringic acid

Sarcolobus globosus

IC50: above 0.167 mM

0.09

hesperetin

Oryctolagus cuniculus

IC50: 0.09 mM

0.167

isotachioside

Sarcolobus globosus

IC50: above 0.167 mM

0.0003

jaspaquinol

Oryctolagus cuniculus

IC50: 0.0003 mM

0.0138

methyl 11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.0076 - 0.05

michellamine B

0.006 - 0.018

morin

0.006 - 0.018

myricetin

0.00535

N'-(4-methylphenyl)benzohydrazide

Homo sapiens

pH and temperature not specified in the publication

742080

0.031 - 0.186

N'-[2-[5-(4-methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]ethyl]-N-methyl-N-[(3R)-1-phenoxypyrrolidin-3-yl]sulfamide

0.08 - 0.822

N'-[2-[5-(4-methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]ethyl]-N-methyl-N-[(3S)-1-phenoxypyrrolidin-3-yl]sulfamide

0.038 - 0.375

N'-[2-[5-(4-methoxyphenyl)-2-thioformyl-1H-imidazol-4-yl]ethyl]-N-methyl-N-[(3R)-1-phenoxypyrrolidin-3-yl]sulfamide

0.057

N,2-dihydroxybenzamide

Oryctolagus cuniculus

IC50: 0.057 mM

0.000099

N-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxamide

Homo sapiens

pH not specified in the publication, temperature not specified in the publication

0.0001

N-(2-chloro-4-fluorophenyl)-1H-pyrazole-3-carboxamide

Homo sapiens

pH not specified in the publication, temperature not specified in the publication

0.01 - 0.132

N-ethyl-N'-[2-[5-(4-methoxyphenyl)-2-thioformyl-1H-imidazol-4-yl]ethyl]-N-[(3R)-1-(1-methyl-1-phenylethyl)pyrrolidin-3-yl]sulfamide

0.003 - 0.75

N-ethyl-N-[(3R)-1-[1-(4-fluorophenyl)ethyl]pyrrolidin-3-yl]-N'-[2-[5-(4-methoxyphenyl)-2-thioformyl-1H-imidazol-4-yl]ethyl]sulfamide

0.011 - 0.083

N-[(3R)-1-(3,4-dichlorobenzyl)pyrrolidin-3-yl]-N'-[2-[5-(4-methoxyphenyl)-2-thioformyl-1H-imidazol-4-yl]ethyl]-N-methylsulfamide

0.1

N-[(5-bromo-8-hydroxy-5,6,7,8-tetrahydroquinolin-7-yl)(thiophen-2-yl)methyl]acetamide

Pseudomonas aeruginosa

pH 6.5, 2°C, recombinant His6-tagged enzyme

0.00046

N-[2-(1H-indol-3-yl)ethyl]-2'-methylbiphenyl-4-sulfonamide

Oryctolagus cuniculus

IC50: 0.00092 mM in the presence of arachidonate, IC50: 0.00046 mM in the presence of linoleic acid

0.00032

N-[2-(1H-indol-3-yl)ethyl]-3'-methylbiphenyl-4-sulfonamide

Oryctolagus cuniculus

IC50: 0.00045 mM in the presence of arachidonate, IC50: 0.00032 mM in the presence of linoleic acid

0.00014

N-[2-(1H-indol-3-yl)ethyl]-4'-(1-methylethyl)biphenyl-4-sulfonamide

Oryctolagus cuniculus

IC50: 0.00028 mM in the presence of arachidonate, IC50: 0.00014 mM in the presence of linoleic acid

0.00017

N-[2-(1H-indol-3-yl)ethyl]-4'-(2-methylpropyl)biphenyl-4-sulfonamide

Oryctolagus cuniculus

IC50: 0.00091 mM in the presence of arachidonate, IC50: 0.00017 mM in the presence of linoleic acid

0.00109

N-[2-(1H-indol-3-yl)ethyl]-4'-methoxybiphenyl-4-sulfonamide

Oryctolagus cuniculus

IC50: 0.0015 mM in the presence of arachidonate, IC50: 0.00109 mM in the presence of linoleic acid

0.00047

N-[2-(1H-indol-3-yl)ethyl]-4'-methylbiphenyl-4-sulfonamide

Oryctolagus cuniculus

IC50: 0.00047 mM in the presence of linoleic acid

0.01

N-[2-(1H-indol-3-yl)ethyl]-4-methylbenzenesulfonamide

Oryctolagus cuniculus

IC50: 0.01 mM in the presence of arachidonate, IC50: 0.01 mM in the presence of linoleic acid

0.00102

N-[2-(1H-indol-3-yl)ethyl]-4-pentylbenzenesulfonamide

Oryctolagus cuniculus

IC50: 0.00042 mM in the presence of arachidonate, IC50: 0.00102 mM in the presence of linoleic acid

0.0032

N-[2-(1H-indol-3-yl)ethyl]-4-propylbenzenesulfonamide

Oryctolagus cuniculus

IC50: 0.00313 mM in the presence of arachidonate, IC50: 0.0032 mM in the presence of linoleic acid

0.0042

N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-sulfonamide

Oryctolagus cuniculus

IC50: 0.0034 mM in the presence of arachidonate, IC50: 0.0042 mM in the presence of linoleic acid

0.000364 - 0.0028

N-[2-(2,5-diphenyl-1H-imidazol-4-yl)ethyl]-4-methylbenzenesulfonamide

0.000033 - 0.000162

N-[2-(2,5-diphenyl-1H-imidazol-4-yl)ethyl]-4-pentylbenzenesulfonamide

0.01

N-[2-(2-cyclopropyl-5-phenyl-1H-imidazol-4-yl)ethyl]-4-pentylbenzenesulfonamide

0.01

N-[2-(2-methyl-5-phenyl-1H-imidazol-4-yl)ethyl]-4-pentylbenzenesulfonamide

Homo sapiens

above, versus substrate linoleic acid

0.00192 - 0.01

N-[2-(2-tert-butyl-5-phenyl-1H-imidazol-4-yl)ethyl]-4-pentylbenzenesulfonamide

0.00072

N-[2-[2-(2-methyl-1,3-thiazol-4-yl)-5-phenyl-1H-imidazol-4-yl]ethyl]-4-pentylbenzenesulfonamide

Homo sapiens

versus substrate linoleic acid

0.000099 - 0.0011

N-[2-[2-(3-nitrophenyl)-5-phenyl-1H-imidazol-4-yl]ethyl]-4-pentylbenzenesulfonamide

0.000021 - 0.0011

N-[2-[2-(4-chlorophenyl)-5-phenyl-1H-imidazol-4-yl]ethyl]-4-pentylbenzenesulfonamide

0.01

N-[2-[2-(4-methoxyphenyl)-5-phenyl-1H-imidazol-4-yl]ethyl]-4-pentylbenzenesulfonamide

Homo sapiens

above, versus substrate linoleic acid

0.003

N-[2-[2-(4-methylphenyl)-5-phenyl-1H-imidazol-4-yl]ethyl]-4-pentylbenzenesulfonamide

Homo sapiens

versus substrate linoleic acid

0.000082 - 0.000531

N-[2-[5-(3-methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]ethyl]-4-pentylbenzenesulfonamide

0.000059 - 0.000261

N-[2-[5-(4-fluorophenyl)-2-phenyl-1H-imidazol-4-yl]ethyl]-4-pentylbenzenesulfonamide

0.000014 - 0.00005

N-[2-[5-(4-methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]ethyl]-4-pentylbenzenesulfonamide

0.212 - 3.45

N-[2-[5-(4-methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]ethyl]-4-phenylpiperazine-1-sulfonamide

0.083 - 0.719

N-[2-[5-(4-methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]ethyl]-N'-[(3R)-1-phenoxypyrrolidin-3-yl]sulfamide

0.272 - 2.41

N-[2-[5-(4-methoxyphenyl)-2-phenyl-1H-imidazol-4-yl]ethyl]-N'-[(3S)-1-phenoxypyrrolidin-3-yl]sulfamide

0.091 - 0.646

N-[2-[5-(4-methoxyphenyl)-2-thioformyl-1H-imidazol-4-yl]ethyl]-4-pentylpiperazine-1-sulfonamide

0.00014 - 0.000914

N-[3-(2,5-diphenyl-1H-imidazol-4-yl)propyl]-4-pentylbenzenesulfonamide

0.25

naringenin

Oryctolagus cuniculus

IC50: 0.25 mM

0.000025

NDGA

Homo sapiens

pH not specified in the publication, temperature not specified in the publication

0.5

neodysidenin

Homo sapiens

above, pH 7.5, recombinant isozyme 15-hLO-1

685525

0.00011 - 0.0018

nordihydroguaiaretic acid

4 entries

0.0094 - 0.05

NSC172033

0.025 - 0.05

NSC292213

0.05 - 0.5

NSC617570

0.00038

PD 146 176

Oryctolagus cuniculus

IC50: 0.00038 mM

0.00381

PD-146176

Oryctolagus cuniculus

IC50: 0.00381 mM

0.00697

phenyl[(E)-phenyldiazenyl]methanone

Homo sapiens

pH and temperature not specified in the publication

742080

0.004 - 0.029

quercetin

rutin

Oryctolagus cuniculus

IC50: 1 mM

0.06

sarcolobin

Sarcolobus globosus

IC50: 0.06 mM

0.0012

squalene

Prunus persica

IC50 is 0.0012 mM

639236

0.0668

stylosin

Homo sapiens

pH 7.0, 25°C

0.167

tachioside

Sarcolobus globosus

IC50: above 0.167 mM

0.025 - 1

taxifolin

0.064

tephrosin

Sarcolobus globosus

IC50: 0.064 mM

0.16

tert-butylhydroxyanisol

Oryctolagus cuniculus

IC50: 0.16 mM

0.017 - 0.028

Toluene-4-sulfonic acid 6,7-diphenyl-pyrrolo[1,2-b]pyridazin-5-yl ester

0.017 - 0.025

toluene-4-sulfonic acid 7-cyano-2,3-diphenyl-indolizin-1-yl ester

0.161

vanillic acid 4-O-beta-D-glucoside

Sarcolobus globosus

IC50: 0.161 mM

0.1

additional information

Homo sapiens

IC50 above 0.1 mM: compound 1a, compound 1b, compound 1d, compound 1e, compound 1g