1.13.11.31: arachidonate 12-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 12-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.31

1.13.11.31

arachidonic

cyclooxygenase

12-hete

eicosanoids

prostaglandin

endothelial

phospholipase

neutrophil

atherosclerosis

polyunsaturated

linoleic

artery

baicalein

lipoxins

hetes

monocyte

12-hydroxyeicosatetraenoic

cox-2

reticulocyte

asthma

nordihydroguaiaretic

thromboxane

eicosapentaenoic

hydroperoxide

ndga

polymorphonuclear

atherogenesis

docosahexaenoic

indomethacin

5,8,11,14-eicosatetraynoic

etya

zileuton

13-hode

hydroperoxy

lipoxygenase-1

erythroderma

hydroxyeicosatetraenoic

medicine

esculetin

protectins

ichthyosiform

resolvins

polyenoic

pro-resolving

drug development

14carachidonic

ichthyosis

ferroptosis

5-lipoxygenase-activating

phenidone

a23187-stimulated

oxylipins

Reaction

(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate

Synonyms

(12R)-lipoxygenase, (12R)-LOX, 11R-lipoxygenase, 11R-LOX, 12(R)-lipoxygenase, 12(S)-lipoxygenase, 12-hLO, 12-lipoxygenase, 12-LO, 12-LOX, 12/15 lipoxygenase, 12/15 Lox, 12/15-lipoxygenase, 12/15-lipoxygenases, 12/15-LO, 12/15-LOX, 12/15LO, 12DELTA-lipoxygenase, 12LO, 12R-lipoxygenase, 12R-LOX, 12R-LOX-2, 12S-lipoxygenase, 15-lipoxygenase, 15-LO, 15-LOX-1, 2-lipoxygenase, 2/15-lipoxygenase, ALOX 12, ALOX 12/15, ALOX12, Alox12b, Alox12e, Alox15, ALOX15B, ALOX5, arachidonate 12/15-lipoxygenase, C-12 lipoxygenase, cardiac 12/15-LOX, DELTA 12-lipoxygenase, epidermal-type lipoxygenase, hp-12LOX, human platelet 12-lipoxygenase, leukocyte-type 12-lipoxygenase, leukocyte-type 12-LOX, leukocyte-type 12/15-lipoxygenase, leukocyte-type lipoxygenase, leukotriene A4 synthase M, lipoxygenase 12, LOX, LOX-12, LOX1, LTA4 synthase, oxylipin-producing enzyme, oygenase, arachidonate 12-lip-, P-12LOX, p12-LO, p12-LOX, platelet 12-lipoxygenase, platelet-type 12(S)-lipoxygenase, platelet-type 12-human lipoxygenase, platelet-type 12-lipoxygenase, platelet-type 12-LOX, platelet-type 12LO, Platelet-type lipoxygenase 12, WP_046712474, zf12-LOX

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.31 arachidonate 12-lipoxygenase

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Results	in table
9	Activating Compound
24	AA Sequence
20	Application
1	CAS Registry Number
48	Cloned(Commentary)
3	Crystallization (Commentary)
4450	Disease/ Diagnostics
19	Expression
105	General Information
3	General Stability
96	IC50 Value
205	Inhibitors
24	kcat/KM [mM/s]
5	Ki Value [mM]
60	KM Value [mM]
26	Localization
22	Metals/Ions
9	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
603	Organism
10	Pathway
6	PDB ID
25	pH Optimum
4	pH Range
64	Protein Variants
29	Purification (Commentary)
1	Reaction
5	Reaction Type
173	Reference
209	Source Tissue
18	Specific Activity [micromol/min/mg]
12	Storage Stability
315	Substrates and Products (Substrate)
16	Subunits
249	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
1	Temperature Range [°C]
11	Temperature Stability [°C]
34	Turnover Number [1/s]

Sequence

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Sequence on EC 1.13.11.31 - arachidonate 12-lipoxygenase

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P18054 pBLAST

LOX12_HUMAN

Homo sapiens

663

75694

Swiss-Prot