1.13.11.27: 4-hydroxyphenylpyruvate dioxygenase
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For detailed information about 4-hydroxyphenylpyruvate dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.27
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1.13.11.27
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syncytial
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viruses
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newcastle
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hn
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paramyxovirus
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epitope
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hemagglutinin-neuraminidase
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infant
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measles
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parainfluenza
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herbicide
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sendai
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homogentisate
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heptad
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hemagglutinin
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virion
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fusogenic
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tyrosinemia
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metapneumovirus
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prefusion
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anti-f
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palivizumab
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weed
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postfusion
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paramyxoviridae
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furin
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distemper
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ectodomains
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mumps
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virus-cell
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rsv-infected
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six-helix
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cleavability
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formalin-inactivated
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lasota
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virus-neutralizing
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virus-like
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morbillivirus
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panencephalitis
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ntbc
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anti-rsv
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nipah
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velogenic
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nucleopolyhedrovirus
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drug development
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alkaptonuria
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diagnostics
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thomsen-friedenreich
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agriculture
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environmental protection
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rinderpest
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live-attenuated
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medicine
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merger
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fumarylacetoacetate
- 1.13.11.27
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syncytial
- viruses
- newcastle
- hn
- paramyxovirus
- epitope
- hemagglutinin-neuraminidase
- infant
- measles
- parainfluenza
-
herbicide
-
sendai
- homogentisate
-
heptad
- hemagglutinin
- virion
-
fusogenic
- tyrosinemia
- metapneumovirus
-
prefusion
-
anti-f
-
palivizumab
-
weed
-
postfusion
- paramyxoviridae
- furin
- distemper
- ectodomains
- mumps
-
virus-cell
-
rsv-infected
-
six-helix
-
cleavability
-
formalin-inactivated
-
lasota
-
virus-neutralizing
-
virus-like
- morbillivirus
- panencephalitis
- ntbc
-
anti-rsv
-
nipah
-
velogenic
- nucleopolyhedrovirus
- drug development
- alkaptonuria
- diagnostics
-
thomsen-friedenreich
- agriculture
- environmental protection
- rinderpest
-
live-attenuated
- medicine
-
merger
- fumarylacetoacetate
Reaction
Synonyms
4-HPPD, 4-hydroxyphenylpyruvare dioxygenase, 4-hydroxyphenylpyruvate dioxygenase, 4-hydroxyphenylpyruvic acid dioxygenase, 4HPPD, ASJ32_19370, At-HPPD, AtHPPD, AvHPPD-03, EC 1.14.2.2, EC 1.99.1.14, formerly, F Alloantigen, F protein, F-antigen homolog, HPD, hpdA, HPPD, HPPDase, Legiolysin, MsHPPD, oxygenase, 4-hydroxyphenylpyruvate di-, p-hydroxyphenyl pyruvate dioxygenase, p-hydroxyphenylpyruvate dioxygenase, p-hydroxyphenylpyruvate hydroxylase, p-hydroxyphenylpyruvate oxidase, p-hydroxyphenylpyruvic acid hydroxylase, p-hydroxyphenylpyruvic hydroxylase, p-hydroxyphenylpyruvic oxidase, PTO1369, Pt_Hpd, T-cell reactive protein, TF-AG, YS103B
ECTree
1.13.11.27 4-hydroxyphenylpyruvate dioxygenaseAdvanced search results
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results (Application
Application on EC 1.13.11.27 - 4-hydroxyphenylpyruvate dioxygenase
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
agriculture
analysis
colorimetric bacterial whole-cell screening system based on the degradation of tyrosine through 4-hydroxyphenylpyruvate into homogentisate by human HPD expressed in Escherichia coli and subsequent production of a soluble melanin-like pigment. The addition of prototypical beta-triketone HPD inhibitors decreases pigment production in a dose-dependent manner with increasing inhibitor concentrations. The high-throughput screening assay shows plate uniformity, signal variability and spatial uniformity assessment
diagnostics
the enzyme can be used for enzyme-based sensors for monitoring herbicides used in agriculture, i.e. mesotrione. Compared to the standard sensors, biosensors have assorted advantages, such as practicality, quick response, low cost, and high sensitivity. A nanobiosensor is developed based on HPPD for mesotrione detection
drug development
environmental protection
the enzyme can be used for enzyme-based sensors for monitoring herbicides used in agriculture, i.e. mesotrione. Compared to the standard sensors, biosensors have assorted advantages, such as practicality, quick response, low cost, and high sensitivity. A nanobiosensor is developed based on HPPD for mesotrione detection
medicine
synthesis
overexpression of the HppD gene in Escherichia coli to produce large amounts of pyomelanin for biotechnological purposes. The recombinant dioxygenase expression leads to the production of pyomelanin in Escherichia coli. When cells are grown at the mid-exponential phase in a mineral medium with added glucose 10 mM and casamino acid 0.2 % w/v, the administration of tyrosine 1 mM after 30 minutes of exposure to arabinose 1 % w/v allows to purify 213 mg/l of pyomelanin after 6 days of biotransformation
agriculture
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overexpression of enzyme in Nicotiana tabacum, transgenic plants have a 10-fold higher resistance to the bleaching herbicide sulcotrione, transgenic seeds have an up to two-fold enhanced level of vitamin E without change in the ratio of gamma-tocopherol and gamma-tocotrienol. Level of plastoquinone is enhanced in leaves of transgenic lines during leaf senescence
agriculture
4-hydroxyphenylpyruvate dioxygenase is one of the most promising target sites for herbicide discovery
agriculture
plant 4-hydroxyphenylpyruvate dioxygenase (HPPD) is the molecular target of a range of commercial synthetic beta-triketone herbicides Their mode of action is based on an irreversible inhibition of HPPD
agriculture
the enzyme is a target for herbicides, e.g. triketone inhibitors
agriculture
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4-hydroxyphenylpyruvate dioxygenase modified at position 336 (HPPD W336) is expressed in MST-FGO72-2 soybean to confer tolerance to 4-benzoyl isoxazole and triketone type of herbicides. No relevant sequence homologies are found with known allergens or toxins, and the absence of hemolytic activity of HPPD W336 is demonstrated in vitro. HPPD W336 degrades rapidly in simulated gastric fluid. Expression of HPPD W336 does not change aromatic amino acid, homogentisate and tocochromanol levels in soybean seed
agriculture
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analysis of two waterhemp populations resistant to p-hydroxyphenylpyruvate-dioxygenase herbicides shows that the HPPD-resistance trait is polygenic. The number of genes involved with the herbicide resistance increase at higher herbicide rates, indicating at least one dominant allele at each major locus is required to confer HPPD herbicide resistance in waterhemp
agriculture
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4-hydroxyphenylpyruvate dioxygenase modified at position 336 (HPPD W336) is expressed in MST-FGO72-2 soybean to confer tolerance to 4-benzoyl isoxazole and triketone type of herbicides. No relevant sequence homologies are found with known allergens or toxins, and the absence of hemolytic activity of HPPD W336 is demonstrated in vitro. HPPD W336 degrades rapidly in simulated gastric fluid. Expression of HPPD W336 does not change aromatic amino acid, homogentisate and tocochromanol levels in soybean seed
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drug development
4-hydroxyphenylpyruvate dioxygenase (HPPD), an essential enzyme in tyrosine catabolism, is an important target for treating type I tyrosinemia
drug development
4-hydroxyphenylpyruvate dioxygenase is one of the most promising target sites for herbicide discovery
drug development
plant 4-hydroxyphenylpyruvate dioxygenase (HPPD) is the molecular target for development of specific inhibitors
drug development
the enzyme is a target for inhibitor and herbicide development
drug development
the enzyme is an important target for treating type I tyrosinemia and alkaptonuria due to its significant role in tyrosine catabolism
drug development
the human enzyme is a target for drug development in treatment of type 1 tyrosinemia, alkaptonuria, and hawkinsinuria, overvuew
medicine
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mechanism of binding of the inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione used to treat type I tyrosinemia. Enzyme-Fe(II)-inhibitor complex does not oxidize, dissociation rate constant is essentially zero
medicine
4-hydroxyphenylpyruvate dioxygenase (HPPD), an essential enzyme in tyrosine catabolism, is an important target for treating type I tyrosinemia
medicine
compounds N-(4-methoxyphenyl)-7-nitro-2,1,3-benzoxadiazol-4-amine and 3-(2-bromo-4-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one can be potentially useful for the treatment of type I tyrosinemia and other diseases with defects in tyrosine degradation
medicine
HPD is highly expressed in lung cancer and expression correlates with poor prognosis in lung cancer patients. Suppressed HPD expression is sufficient to decrease oxidative pentose phosphate pathway flux, leading to reduced RNA biosynthesis and enhanced reactive oxygen species level, attenuated cancer cell proliferation, and tumor growth
