1.13.11.12: linoleate 13S-lipoxygenase

This is an abbreviated version!
For detailed information about linoleate 13S-lipoxygenase, go to the full flat file.

Reaction

Synonyms

(13S)-lipoxygenase, 13-lipoxygenase, 13-LOX, 13S-lipoxygenase, 15-lipoxygenase-1, 15-LOX-1, 9/13-LOX, acidic lipoxygenase, Alox15, arachidonic acid 15S-lipoxygenating enzyme, AtLOX-2, AtLOX-3, AtLOX-4, AtLOX-6, CmLOX10, CmLOX13, iron 13S-lipoxygenase, liipoxygenase, linoleate 13-lipoxygenase, linoleate 13S-lipoxygenase, linoleate oxygen oxidoreductase, linoleate: oxygen oxidoreductase, linoleate:oxygen oxidoreductase, lipoxygenase, lipoxygenase 2, lipoxygenase-1, lipoxygenase-2, lipoxygenase-3, lipoxygenase-4, lipoxygenase-6, LO-1, LOX, LOX-1, LOX-2, LOX1, LOX10, LOX11, LOX12, LOX2, LOX2:Hv:1, LOX2:Md:2b, LOX2b, LOX3, LOX4, LOX6, LOX7, LOX8, LOX9, LoxA, Lpx-A2, MSD2, Oep1LOX2, Oep2LOX2, omega-6 linoleate lipoxygenase, PA-LOX, RCI-1, SBLO-1, secreted lipoxygenase, SLO, soybean lipoxygenase-1, StLOX2, StLOX3, type-1 LOX, type-2 13-LOX

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.12 linoleate 13S-lipoxygenase

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Results	in table
2	Activating Compound
107	AA Sequence
15	Application
1	CAS Registry Number
30	Cloned(Commentary)
1	Crystallization (Commentary)
3835	Disease/ Diagnostics
18	Expression
35	General Information
109	IC50 Value
175	Inhibitors
18	kcat/KM [mM/s]
23	Ki Value [mM]
63	KM Value [mM]
20	Localization
32	Metals/Ions
15	Molecular Weight [Da]
43	Natural Substrates/ Products (Substrates)
85	Organism
9	Pathway
44	PDB ID
27	pH Optimum
16	pH Range
2	pH Stability
6	pI Value
6	Protein Variants
21	Purification (Commentary)
3	Reaction
3	Reaction Type
69	Reference
51	Source Tissue
14	Specific Activity [micromol/min/mg]
1	Storage Stability
147	Substrates and Products (Substrate)
28	Subunits
155	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
17	Temperature Range [°C]
4	Temperature Stability [°C]
23	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 1.13.11.12 - linoleate 13S-lipoxygenase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

20 - 40

Burkholderia thailandensis

-

thermal inactivation of the purified recombinant enzyme follows first-order kinetics, with half-lives for linoleic acid of 900, 122, 51, and 21 min at 20°C, 25°C, 30°C, 35!C, and 40°C, respectively. Instability of the enzyme above 30°C

741748

20 - 65

Pseudomonas aeruginosa

-

purified extracellular enzyme, 25°C, 7 min, stable at up to 35°C, loss of 10% activity at 40°C, and of 20% at 50°C, 10% activity remaining at 60°C, inactivation at 65°C

724085

25 - 60

Myxococcus xanthus

Q1DBH9

the thermal stability is highest at 25°C. Less than 50% of the original activity remains after heat treatment at 50°C for 5 min, and the enzyme is completely inactive after treatment at 60°C for 10 min

765704

40 - 70

Glycine max

-

the enzyme shows no loss of catalytic activity at temperatures up to 40°C after 15 min incubation. When the temperature increases above 40 °C, the enzyme dramatically loses its catalytic activity by 56% at 60°C and is fully deactivated at 70°C

764604