1.12.98.2: 5,10-methenyltetrahydromethanopterin hydrogenase

This is an abbreviated version!
For detailed information about 5,10-methenyltetrahydromethanopterin hydrogenase, go to the full flat file.

Reaction

Synonyms

5,10-methylene-H4MPT dehydrogenase, Dehydrogenase, methylenetetrahydromethanopterin, EC 1.12.99.4, H2-forming methylenetetrahydromethanopterin dehydrogenase, H2-forming N5,N10-Methenyltetrahydromethanopterin dehydrogenase, Hmd, methylenetetrahydromethanopterin dehydrogenase, N5,N10-methenyltetrahydromethanopterin hydrogenase, N5,N10-Methylenetetrahydromethanopterin dehydrogenase, N5,N10-methylenetetrahydromethanopterin dehydrogenase (H2-forming)

ECTree

     1 Oxidoreductases

         1.12 Acting on hydrogen as donor

             1.12.98 With other, known, physiological acceptors

                1.12.98.2 5,10-methenyltetrahydromethanopterin hydrogenase

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Results	in table
148	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
6	Cofactor
2	Crystallization (Commentary)
5	General Stability
7	Inhibitors
4	Ki Value [mM]
14	KM Value [mM]
20	Metals/Ions
16	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
143	Organism
5	Oxidation Stability
7	Pathway
19	PDB ID
4	pH Optimum
1	pH Range
1	pI Value
7	Purification (Commentary)
4	Reaction
4	Reaction Type
27	Reference
6	Specific Activity [micromol/min/mg]
2	Storage Stability
39	Substrates and Products (Substrate)
15	Subunits
13	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
2	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.12.98.2 - 5,10-methenyltetrahydromethanopterin hydrogenase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

5,10-methenyltetrahydromethanopterin + H2

5,10-methylenetetrahydromethanopterin + H+

8 entries

H+ + 5,10-methylenetetrahydromethanopterin

H2 + 5,10-methenyltetrahydromethanopterin

4 entries

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

13 entries

additional information

?

-

5 entries

5,10-methenyltetrahydromethanopterin + H2

5,10-methylenetetrahydromethanopterin + H+

Methanocaldococcus jannaschii

-

-

658635

-

-

r

5,10-methenyltetrahydromethanopterin + H2

5,10-methylenetetrahydromethanopterin + H+

Methanocaldococcus jannaschii

-

involved in methanogenesis

658635

-

-

r

5,10-methenyltetrahydromethanopterin + H2

5,10-methylenetetrahydromethanopterin + H+

Methanocaldococcus jannaschii

Q58194

Hmd catalyzes a step in the hydrogenotrophic methanogenesis pathway in class I methanogens

696971

-

-

?

5,10-methenyltetrahydromethanopterin + H2

5,10-methylenetetrahydromethanopterin + H+

Methanothermobacter marburgensis

-

-

658635, 658966

-

-

r

5,10-methenyltetrahydromethanopterin + H2

5,10-methylenetetrahydromethanopterin + H+

Methanothermobacter marburgensis

-

involved in methanogenesis

658635, 658966, 658978

-

-

r

5,10-methenyltetrahydromethanopterin + H2

5,10-methylenetetrahydromethanopterin + H+

Methanothermobacter marburgensis

-

reverse reaction under argon atmosphere

658978

-

-

r

5,10-methenyltetrahydromethanopterin + H2

5,10-methylenetetrahydromethanopterin + H+

Methanothermobacter thermautotrophicus

-

-

657579

-

-

?

5,10-methenyltetrahydromethanopterin + H2

5,10-methylenetetrahydromethanopterin + H+

Methanothermobacter thermautotrophicus

-

involved in methanogenesis

657579

-

-

?

H+ + 5,10-methylenetetrahydromethanopterin

H2 + 5,10-methenyltetrahydromethanopterin

Methanothermobacter marburgensis

P32440

the purified enzyme does not catalyze the reduction of viologen dyes, of methylene blue, of flavins, of pyridine nucleotides

727402

-

-

r

H+ + 5,10-methylenetetrahydromethanopterin

H2 + 5,10-methenyltetrahydromethanopterin

Methanothermobacter marburgensis DSM 2133

P32440

the purified enzyme does not catalyze the reduction of viologen dyes, of methylene blue, of flavins, of pyridine nucleotides

727402

-

-

r

H+ + 5,10-methylenetetrahydromethanopterin

H2 + 5,10-methenyltetrahydromethanopterin

Methanothermobacter wolfeii

P32441

-

727402

-

-

r

H+ + 5,10-methylenetetrahydromethanopterin

H2 + 5,10-methenyltetrahydromethanopterin

Methanothermobacter wolfeii DSM 2970

P32441

-

727402

-

-

r

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanopyrus kandleri

-

r

394697

-

-

?

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanopyrus kandleri

-

no reaction with: coenzyme F420, NAD+, NADP+

394697

-

-

?

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanopyrus kandleri

-

reverse reaction is favoured under alkaline conditions

394697

-

-

?

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanothermobacter thermautotrophicus

-

-

394691, 394693, 394695

-

-

?

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanothermobacter thermautotrophicus

-

r

394690, 394692, 394694, 394696

-

-

?

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanothermobacter thermautotrophicus

-

no reaction with: coenzyme F420, NAD+, NADP+

394694

-

-

?

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanothermobacter thermautotrophicus

-

no reaction with viologen dyes

394694

-

-

?

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanothermobacter thermautotrophicus Marburg / DSM 2133

-

r

394690

-

-

?

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanothermobacter thermautotrophicus Marburg / DSM 2133

-

-

394691

-

-

?

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanothermobacter thermautotrophicus Marburg / DSM 2133

-

r

394692, 394694

-

-

?

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanothermobacter thermautotrophicus Marburg / DSM 2133

-

no reaction with: coenzyme F420, NAD+, NADP+

394694

-

-

?

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanothermobacter thermautotrophicus Marburg / DSM 2133

-

no reaction with viologen dyes

394694

-

-

?

N5,N10-methylenetetrahydromethanopterin + H+

N5,N10-methenyltetrahydromethanopterin + H2

Methanothermococcus thermolithotrophicus

-

r

394696

-

394696

?

additional information

?

-

Methanocaldococcus jannaschii

-

no reduction of methyl viologen or methyl blue

658635

-

-

?

additional information

?

-

Methanopyrus kandleri

-

the enzyme is involved in methanogenesis from CO2 and H2

394697

-

-

?

additional information

?

-

Methanothermobacter marburgensis

-

no reduction of methyl viologen or methyl blue

658635

-

-

?

additional information

?

-

Methanothermobacter marburgensis

-

no reduction of viologen dyes in the presence of H2

658978

-

-

?

additional information

?

-

Methanothermobacter thermautotrophicus

-

under conditions of nickel limitation, the reduction of F420 with H2 is catalyzed by the metal-free methylenetetrahydromethanopterin dehydrogenase system which is composed of H2-forming methylenetetrahydromethanopterin dehydrogenase and F420-dependent methylenetetrahydromethanopterin dehydrogenase

394695

-

-

?