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1.12.1.4: hydrogenase (NAD+, ferredoxin)

This is an abbreviated version!
For detailed information about hydrogenase (NAD+, ferredoxin), go to the full flat file.

Word Map on EC 1.12.1.4

Reaction

2 H2 +

NAD+
+ 2 oxidized ferredoxin = 5 H+ +
NADH
+ 2 reduced ferredoxin

Synonyms

bifurcating [FeFe] hydrogenase, electron-bifurcating ferredoxin- and NAD-dependent hydrogenase, Fe-only hydrogenase, HydABC, HydC, HydF, iron hydrogenase, NAD(P)+-linked [FeFe]-hydrogenase, [FeFe]-hydrogenase, [FeFe]-type hydrogenase

ECTree

     1 Oxidoreductases
         1.12 Acting on hydrogen as donor
             1.12.1 With NAD+ or NADP+ as acceptor
                1.12.1.4 hydrogenase (NAD+, ferredoxin)

Engineering

Engineering on EC 1.12.1.4 - hydrogenase (NAD+, ferredoxin)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A85P
-
the mutant has an altered reduction potential compared to the wild type enzyme
V131N
-
the mutant has an altered reduction potential compared to the wild type enzyme
A85P
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
-
the mutant has an altered reduction potential compared to the wild type enzyme
-
V131N
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
-
the mutant has an altered reduction potential compared to the wild type enzyme
-
C302S
-
mutant displays a very weak electron paramagnetic resonance signal
C353S
-
mutant displays a very weak electron paramagnetic resonance signal
C356S
-
mutant displays a very weak electron paramagnetic resonance signal
H304A
-
similar to wild-type, mutant exhibits electron paramagnetic resonance signals characteristic of oxidized [3Fe-4S]+ cluster
H352A
-
similar to wild-type, mutant exhibits electron paramagnetic resonance signals characteristic of oxidized [3Fe-4S]+ cluster