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1.11.2.2: myeloperoxidase

This is an abbreviated version!
For detailed information about myeloperoxidase, go to the full flat file.

Word Map on EC 1.11.2.2

Reaction

Cl-
+
H2O2
 +
H+
=
HClO
 +
H2O

Synonyms

donor, hydrogen peroxide oxidoreductase, donor, hydrogen peroxideoxidoreductase, donor: H2O2 oxidoreductase, donor:H2O2 oxidoreductase, donor:hydrogen peroxide oxidoreductase, donor:hydrogen-peroxide oxidoreductase, EC 1.11.1.7, epx2a, hemi-MPO, hemi-myeloperoxidase, LPO, MPO, MPX, myeloperoxidase, peroxinectin, properoxinectin, recombinant human MPO, rhMPO, tissue myeloperoxidase

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.2 Peroxygenases
                1.11.2.2 myeloperoxidase

Reference

topprint

Reference on EC 1.11.2.2 - myeloperoxidase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Arnhold, J.; Furtmuller, P.G.; Regelsberger, G.; Obinger, C.
Redox properties of the couple compound I/native enzyme of myeloperoxidase and eosinophil peroxidase
Eur. J. Biochem.
268
5142-5148
2001
Homo sapiens
Manually annotated by BRENDA team
Mathy-Hartert, M.; Bourgeois, E.; Grulke, S.; Deby-Dupont, G.; Caudron, I.; Deby, C.; Lamy, M.; Serteyn, D.
Purification of myeloperoxidase from equine polymorphonuclear leukocytes
Can. J. Vet. Res.
62
127-132
1998
Equus caballus
Manually annotated by BRENDA team
Olsen, R.L.; Little, C.
Studies on the subunits of human myeloperoxidase
Biochem. J.
222
701-709
1984
Homo sapiens
Manually annotated by BRENDA team
Bolscher, B.G.J.M.; Zoutberg, G.R.; Cuperus, R.A.; Wever, R.
Vitamin C stimulates the chlorinating activity of human myeloperoxidase
Biochim. Biophys. Acta
784
189-191
1984
Homo sapiens
Manually annotated by BRENDA team
Olsen, R.L.; Little, C.
Purification and some properties of myeloperoxidase and eosinophil peroxidase from human blood
Biochem. J.
209
781-787
1983
Homo sapiens
Manually annotated by BRENDA team
Hewson, W.D.; Hager, L.P.
Peroxidases, catalases and chloroperoxidase
The Porphyrins (Dolphin, D. , ed. ) Academic Press, New York
7
295-332
1979
Armoracia sp., Bos taurus, Homo sapiens, Raphanus sativus
-
Manually annotated by BRENDA team
Bos, A.; Wever, R.; Roos, D.
Characterization and quantification of the peroxidase in human monocytes
Biochim. Biophys. Acta
525
37-44
1978
Homo sapiens
Manually annotated by BRENDA team
Jantschko, W.; Furtmuller, P.G.; Zederbauer, M.; Jakopitsch, C.; Obinger, C.
Kinetics of oxygen binding to ferrous myeloperoxidase
Arch. Biochem. Biophys.
426
91-97
2004
Homo sapiens
Manually annotated by BRENDA team
Ghibaudi, E.; Laurenti, E.; Pacchiardo, C.; Suriano, G.; Moguilevsky, N.; Pia Ferrari, R.
Organic and inorganic substrates as probes for comparing native bovine lactoperoxidase and recombinant human myeloperoxidase
J. Inorg. Biochem.
94
146-154
2003
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Mathy-Hartert, M.; Deby-Dupont, G.; Melin, P.; Lamy, M.; Deby, C.
Bactericidal activity against Pseudomonas aeruginosa is acquired by cultured human monocyte-derived macrophages after uptake of myeloperoxidase
Experientia
52
167-174
1996
Homo sapiens
Manually annotated by BRENDA team
Mohammed, J.R.; Mohammed, B.S.; Pawluk, L.J.; Bucci, D.M.; Baker, N.R.; Davis, W.B.
Purification and cytotoxic potential of myeloperoxidase in cystic fibrosis sputum
J. Lab. Clin. Med.
112
711-720
1988
Homo sapiens
Manually annotated by BRENDA team
Jantschko, W.; Furtmueller, P.G.; Zederbauer, M.; Neugschwandtner, K.; Lehner, I.; Jakopitsch, C.; Arnhold, J.; Obinger, C.
Exploitation of the unusual thermodynamic properties of human myeloperoxidase in inhibitor design
Biochem. Pharmacol.
69
1149-1157
2005
Homo sapiens
Manually annotated by BRENDA team
Proteasa, G.; Tahboub, Y.R.; Galijasevic, S.; Raushel, F.M.; Abu-Soud, H.M.
Kinetic evidence supports the existence of two halide binding sites that have a distinct impact on the heme iron microenvironment in myeloperoxidase
Biochemistry
46
398-405
2007
Homo sapiens (P05164)
Manually annotated by BRENDA team
Lin, X.; Cerenius, L.; Lee, B.L.; Soederhaell, K.
Purification of properoxinectin, a myeloperoxidase homologue and its activation to a cell adhesion molecule
Biochim. Biophys. Acta
1770
87-93
2007
Pacifastacus leniusculus
Manually annotated by BRENDA team
Spalteholz, H.; Furtmueller, P.G.; Jakopitsch, C.; Obinger, C.; Schewe, T.; Sies, H.; Arnhold, J.
Kinetic evidence for rapid oxidation of (-)-epicatechin by human myeloperoxidase
Biochem. Biophys. Res. Commun.
371
810-813
2008
Homo sapiens
Manually annotated by BRENDA team
Meotti, F.C.; Senthilmohan, R.; Harwood, D.T.; Missau, F.C.; Pizzolatti, M.G.; Kettle, A.J.
Myricitrin as a substrate and inhibitor of myeloperoxidase: Implications for the pharmacological effects of flavonoids
Free Radic. Biol. Med.
44
109-120
2008
Homo sapiens
Manually annotated by BRENDA team
Devarajan, A.; Gaenko, A.V.; Ryde, U.
Effect of covalent links on the structure, spectra, and redox properties of myeloperoxidase - a density functional study
J. Inorg. Biochem.
102
1549-1557
2008
Homo sapiens
Manually annotated by BRENDA team
Vaz, S.M.; Augusto, O.
Inhibition of myeloperoxidase-mediated protein nitration by tempol: Kinetics, mechanism, and implications
Proc. Natl. Acad. Sci. USA
105
8191-8196
2008
Homo sapiens
Manually annotated by BRENDA team
Shiba, Y.; Kinoshita, T.; Chuman, H.; Taketani, Y.; Takeda, E.; Kato, Y.; Naito, M.; Kawabata, K.; Ishisaka, A.; Terao, J.; Kawai, Y.
Flavonoids as substrates and inhibitors of myeloperoxidase: molecular actions of aglycone and metabolites
Chem. Res. Toxicol.
21
1600-1609
2008
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Tan, S.; Wang, G.; Peng, M.; Zhang, X.; Shen, G.; Jiang, J.; Chen, F.
Detection of myeloperoxidase activity in primary leukemic cells by an enhanced chemiluminescent assay for differentiation between acute lymphoblastic and non-lymphoblastic leukemia
Clin. Chim. Acta
403
216-218
2009
Homo sapiens
Manually annotated by BRENDA team
Chiu, W.C.; Wang, Y.C.; Chien, Y.W.; Hou, Y.C.; Hu, Y.M.; Yeh, S.L.
Effects of dietary fish oil supplementation on cellular adhesion molecule expression and tissue myeloperoxidase activity in hypercholesterolemic mice with sepsis
J. Nutr. Biochem.
20
254-260
2009
Mus musculus
Manually annotated by BRENDA team
Sajad, M.; Zargan, J.; Chawla, R.; Umar, S.; Sadaqat, M.; Khan, H.A.
Hippocampal neurodegeneration in experimental autoimmune encephalomyelitis (EAE): potential role of inflammation activated myeloperoxidase
Mol. Cell. Biochem.
328
183-188
2009
Rattus norvegicus
Manually annotated by BRENDA team
Gray, E.; Thomas, T.L.; Betmouni, S.; Scolding, N.; Love, S.
Elevated myeloperoxidase activity in white matter in multiple sclerosis
Neurosci. Lett.
444
195-198
2008
Homo sapiens
Manually annotated by BRENDA team
Brasen, J.C.; Lunding, A.; Olsen, L.F.
Human myeloperoxidase catalyzes an oscillating peroxidase-oxidase reaction
Arch. Biochem. Biophys.
431
55-62
2004
Homo sapiens
Manually annotated by BRENDA team
Spalteholz, H.; Panasenko, O.M.; Arnhold, J.
Formation of reactive halide species by myeloperoxidase and eosinophil peroxidase
Arch. Biochem. Biophys.
445
225-234
2006
Homo sapiens
Manually annotated by BRENDA team
Senthilmohan, R.; Kettle, A.J.
Bromination and chlorination reactions of myeloperoxidase at physiological concentrations of bromide and chloride
Arch. Biochem. Biophys.
445
235-244
2006
Homo sapiens
Manually annotated by BRENDA team
Allegra, M.; Furtmuller, P.G.; Jantschko, W.; Zederbauer, M.; Tesoriere, L.; Livrea, M.A.; Obinger, C.
Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid
Biochem. Biophys. Res. Commun.
332
837-844
2005
Homo sapiens
Manually annotated by BRENDA team
Kettle, A.J.; Gedye, C.A.; Hampton, M.B.; Winterbourn, C.C.
Inhibition of myeloperoxidase by benzoic acid hydrazides
Biochem. J.
308
559-563
1995
Homo sapiens
Manually annotated by BRENDA team
van Dalen, C.J.; Whitehouse, M.W.; Winterbourn, C.C.; Kettle, A.J.
Thiocyanate and chloride as competing substrates for myeloperoxidase
Biochem. J.
327
487-492
1997
Homo sapiens
Manually annotated by BRENDA team
Capeillere-Blandin, C.; Martin, C.; Gaggero, N.; Pasta, P.; Carrea, G.; Colonna, S.
Sulphoxidation reaction catalysed by myeloperoxidase from human leucocytes
Biochem. J.
335
27-33
1998
Homo sapiens
Manually annotated by BRENDA team
Ximenes, V.F.; Maghzal, G.J.; Turner, R.; Kato, Y.; Winterbourn, C.C.; Kettle, A.J.
Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione
Biochem. J.
425
285-293
2010
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Furtmuller, P.G.; Burner, U.; Obinger, C.
Reaction of myeloperoxidase compound I with chloride, bromide, iodide, and thiocyanate
Biochemistry
37
17923-17930
1998
Homo sapiens (P05164)
Manually annotated by BRENDA team
Blair-Johnson, M.; Fiedler, T.; Fenna, R.
Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution
Biochemistry
40
13990-13997
2001
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Vlasova, II; Arnhold, J.; Osipov, A.N.; Panasenko, O.M.
pH-dependent regulation of myeloperoxidase activity
Biochemistry
71
667-677
2006
Homo sapiens
Manually annotated by BRENDA team
Zuurbier, K.W.; Bakkenist, A.R.; Wever, R.; Muijsers, A.O.
The chlorinating activity of human myeloperoxidase: high initial activity at neutral pH value and activation by electron donors
Biochim. Biophys. Acta
1037
140-146
1990
Homo sapiens
Manually annotated by BRENDA team
Kozik, A.; Golda, A.; Mak, P.; Suder, P.; Silberring, J.; Barbasz, A.; Rapala-Kozik, M.
Myeloperoxidase-catalyzed oxidative inactivation of human kininogens: the impairment of kinin-precursor and prekallikrein-binding functions
Biol. Chem.
392
263-274
2010
Homo sapiens
Manually annotated by BRENDA team
Moguilevsky, N.; Garcia-Quintana, L.; Jacquet, A.; Tournay, C.; Fabry, L.; Pierard, L.; Bollen, A.
Structural and biological properties of human recombinant myeloperoxidase produced by Chinese hamster ovary cell lines
Eur. J. Biochem.
197
605-614
1991
Homo sapiens
Manually annotated by BRENDA team
Zuurbier, K.W.; van den Berg, J.D.; Van Gelder, B.F.; Muijsers, A.O.
Human hemi-myeloperoxidase. Initial chlorinating activity at neutral pH, compound II and III formation, and stability towards hypochlorous acid and high temperature
Eur. J. Biochem.
205
737-742
1992
Homo sapiens
Manually annotated by BRENDA team
Furtmuller, P.G.; Obinger, C.; Hsuanyu, Y.; Dunford, H.B.
Mechanism of reaction of myeloperoxidase with hydrogen peroxide and chloride ion
Eur. J. Biochem.
267
5858-5864
2000
Bos taurus, Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Furtmuller, P.G.; Jantschko, W.; Regelsberger, G.; Jakopitsch, C.; Moguilevsky, N.; Obinger, C.
A transient kinetic study on the reactivity of recombinant unprocessed monomeric myeloperoxidase
FEBS Lett.
503
147-150
2001
Homo sapiens
Manually annotated by BRENDA team
Panasenko, O.M.; Spalteholz, H.; Schiller, J.; Arnhold, J.
Myeloperoxidase-induced formation of chlorohydrins and lysophospholipids from unsaturated phosphatidylcholines
Free Radic. Biol. Med.
34
553-562
2003
Homo sapiens
Manually annotated by BRENDA team
Meotti, F.C.; Jameson, G.N.; Turner, R.; Harwood, D.T.; Stockwell, S.; Rees, M.D.; Thomas, S.R.; Kettle, A.J.
Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammation
J. Biol. Chem.
186
12901-12911
2010
Homo sapiens
Manually annotated by BRENDA team
Marquez, L.A.; Dunford, H.B.
Chlorination of taurine by myeloperoxidase. Kinetic evidence for an enzyme-bound intermediate
J. Biol. Chem.
269
7950-7956
1994
Bos taurus
Manually annotated by BRENDA team
Hazen, S.L.; d'Avignon, A.; Anderson, M.M.; Hsu, F.F.; Heinecke, J.W.
Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to oxidize alpha-amino acids to a family of reactive aldehydes. Mechanistic studies identifying labile intermediates along the reaction pathway
J. Biol. Chem.
273
4997-5005
1998
Homo sapiens
Manually annotated by BRENDA team
van Dalen, C.J.; Winterbourn, C.C.; Senthilmohan, R.; Kettle, A.J.
Nitrite as a substrate and inhibitor of myeloperoxidase. Implications for nitration and hypochlorous acid production at sites of inflammation
J. Biol. Chem.
275
11638-11644
2000
Homo sapiens
Manually annotated by BRENDA team
Fiedler, T.J.; Davey, C.A.; Fenna, R.E.
X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution
J. Biol. Chem.
275
11964-11971
2000
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Rosen, H.; Crowley, J.R.; Heinecke, J.W.
Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis
J. Biol. Chem.
277
30463-30468
2002
Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Rosen, H.; Madtes, D.K.; Shao, B.; Martin, T.R.; Heinecke, J.W.; Fu, X.
Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation
J. Biol. Chem.
282
31826-31834
2007
Homo sapiens
Manually annotated by BRENDA team
Ramos, D.R.; Garcia, M.V.; Canle, L.M.; Santaballa, J.A.; Furtmuller, P.G.; Obinger, C.
Myeloperoxidase-catalyzed chlorination: the quest for the active species
J. Inorg. Biochem.
102
1300-1311
2008
Homo sapiens
Manually annotated by BRENDA team
Gaut, J.P.; Yeh, G.C.; Tran, H.D.; Byun, J.; Henderson, J.P.; Richter, G.M.; Brennan, M.L.; Lusis, A.J.; Belaaouaj, A.; Hotchkiss, R.S.; Heinecke, J.W.
Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis
Proc. Natl. Acad. Sci. USA
98
11961-11966
2001
Homo sapiens
Manually annotated by BRENDA team
Abdel-Naim, A.B.; Mohamadin, A.M.
Myeloperoxidase-catalyzed oxidation of chloroacetonitrile to cyanide
Toxicol. Lett.
146
249-257
2004
Homo sapiens
Manually annotated by BRENDA team
Queiroz, R.F.; Vaz, S.M.; Augusto, O.
Inhibition of the chlorinating activity of myeloperoxidase by tempol: revisiting the kinetics and mechanisms
Biochem. J.
439
423-431
2011
Homo sapiens (P05164)
Manually annotated by BRENDA team
Kubala, L.; Kolarova, H.; Vitecek, J.; Kremserova, S.; Klinke, A.; Lau, D.; Chapman, A.L.; Baldus, S.; Eiserich, J.P.
The potentiation of myeloperoxidase activity by the glycosaminoglycan-dependent binding of myeloperoxidase to proteins of the extracellular matrix
Biochim. Biophys. Acta
1830
4524-4536
2013
Homo sapiens
Manually annotated by BRENDA team
Zeraik, M.L.; Ximenes, V.F.; Regasini, L.O.; Dutra, L.A.; Silva, D.H.; Fonseca, L.M.; Coelho, D.; Machado, S.A.; Bolzani, V.S.
4-Aminochalcones as novel inhibitors of the chlorinating activity of myeloperoxidase
Curr. Med. Chem.
19
5405-5413
2012
Homo sapiens
Manually annotated by BRENDA team
Soubhye, J.; Aldib, I.; Elfving, B.; Gelbcke, M.; Furtmueller, P.G.; Podrecca, M.; Conotte, R.; Colet, J.M.; Rousseau, A.; Reye, F.; Sarakbi, A.; Vanhaeverbeek, M.; Kauffmann, J.M.; Obinger, C.; Neve, J.; Prevost, M.; Zouaoui Boudjeltia, K.; Dufrasne, F.; Van Antwerpen, P.
Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors
J. Med. Chem.
56
3943-3958
2013
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Shazeeb, M.; Xie, Y.; Gupta, S.; Bogdanov Jr., A.
A novel paramagnetic substrate for detecting myeloperoxidase activity in vivo
Mol. Imaging
11
433-443
2012
Mus musculus
Manually annotated by BRENDA team
Huang, J.; Smith, F.; Panizzi, P.
Ordered cleavage of myeloperoxidase ester bonds releases active site heme leading to inactivation of myeloperoxidase by benzoic acid hydrazide analogs
Arch. Biochem. Biophys.
548
74-85
2014
Homo sapiens (P05164)
Manually annotated by BRENDA team
Huang, J.; Smith, F.; Panizzi, J.R.; Goodwin, D.C.; Panizzi, P.
Inactivation of myeloperoxidase by benzoic acid hydrazide
Arch. Biochem. Biophys.
570
14-22
2015
Homo sapiens
Manually annotated by BRENDA team
Ding, Y.; Tian, R.; Yang, Z.; Chen, J.; Lu, N.
Binding of human IgG to single-walled carbon nanotubes accelerated myeloperoxidase-mediated degradation in activated neutrophils
Biophys. Chem.
218
36-41
2016
Homo sapiens
Manually annotated by BRENDA team
Aldib, I.; Gelbcke, M.; Soubhye, J.; Prevost, M.; Furtmueller, P.G.; Obinger, C.; Elfving, B.; Alard, I.C.; Roos, G.; Delporte, C.; Berger, G.; Dufour, D.; Zouaoui Boudjeltia, K.; Neve, J.; Dufrasne, F.; Van Antwerpen, P.
Novel bis-arylalkylamines as myeloperoxidase inhibitors Design, synthesis, and structure-activity relationship study
Eur. J. Med. Chem.
123
746-762
2016
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Sokolov, A.V.; Kostevich, V.A.; Kozlov, S.O.; Donskyi, I.S.; Vlasova, I.I.; Rudenko, A.O.; Zakharova, E.T.; Vasilyev, V.B.; Panasenko, O.M.
Kinetic method for assaying the halogenating activity of myeloperoxidase based on reaction of celestine blue B with taurine halogenamines
Free Radic. Res.
49
777-789
2015
Homo sapiens (P05164)
Manually annotated by BRENDA team
Franck, T.; Minguet, G.; Delporte, C.; Derochette, S.; Zouaoui Boudjeltia, K.; Van Antwerpen, P.; Gach, O.; Deby-Dupont, G.; Mouithys-Mickalad, A.; Serteyn, D.
An immunological method to combine the measurement of active and total myeloperoxidase on the same biological fluid, and its application in finding inhibitors which interact directly with the enzyme
Free Radic. Res.
49
790-799
2015
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Maghzal, G.J.; Cergol, K.M.; Shengule, S.R.; Suarna, C.; Newington, D.; Kettle, A.J.; Payne, R.J.; Stocker, R.
Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium
J. Biol. Chem.
289
5580-5595
2014
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Kato, Y.
Neutrophil myeloperoxidase and its substrates formation of specific markers and reactive compounds during inflammation
J. Clin. Biochem. Nutr.
58
99-104
2016
Homo sapiens (P05164)
Manually annotated by BRENDA team
Flemmig, J.; Remmler, J.; Roehring, F.; Arnhold, J.
(-)-Epicatechin regenerates the chlorinating activity of myeloperoxidase in vitro and in neutrophil granulocytes
J. Inorg. Biochem.
130
84-91
2014
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Delporte, C.; Boudjeltia, K.Z.; Noyon, C.; Furtmueller, P.G.; Nuyens, V.; Slomianny, M.C.; Madhoun, P.; Desmet, J.M.; Raynal, P.; Dufour, D.; Koyani, C.N.; Reye, F.; Rousseau, A.; Vanhaeverbeek, M.; Ducobu, J.; Michalski, J.C.; Neve, J.; Vanhamme, L.; Obinger, C.; Malle, E.; Van Antwerpen, P.
Impact of myeloperoxidase-LDL interactions on enzyme activity and subsequent posttranslational oxidative modifications of apoB-100
J. Lipid Res.
55
747-757
2014
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Hair, P.S.; Sass, L.A.; Krishna, N.K.; Cunnion, K.M.
Inhibition of myeloperoxidase activity in cystic fibrosis sputum by peptide inhibitor of complement C1 (PIC1)
PLoS ONE
12
e0170203
2017
Homo sapiens (P05164)
Manually annotated by BRENDA team
Ponthier, J.; Franck, T.; Parrilla-Hernandez, S.; Niesten, A.; de la Rebiere, G.; Serteyn, D.; Deleuze, S.
Concentration, activity and biochemical characterization of myeloperoxidase in fresh and post-thaw equine semen and their implication on freezability
Reprod. Domest. Anim.
49
285-291
2014
Equus caballus
Manually annotated by BRENDA team
Wurtz, N.; Viet, A.; Shaw, S.; Dilger, A.; Valente, M.; Khan, J.; Jusuf, S.; Narayanan, R.; Fernando, G.; Lo, F.; Liu, X.; Locke, G.; Kopcho, L.; Abell, L.; Sleph, P.; Basso, M.; Zhao, L.; Wexler, R.; Duclos, F.; Kick, E.
Potent triazolopyridine myeloperoxidase inhibitors
ACS Med. Chem. Lett.
9
1175-1180
2018
Homo sapiens (P05164)
Manually annotated by BRENDA team
Coker, M.; Forbes, L.; Plowman-Holmes, M.; Murdoch, D.; Winterbourn, C.; Kettle, A.
Interactions of staphyloxanthin and enterobactin with myeloperoxidase and reactive chlorine species
Arch. Biochem. Biophys.
646
80-89
2018
Homo sapiens (P05164)
Manually annotated by BRENDA team
Gorudko, I.; Grigorieva, D.; Sokolov, A.; Shamova, E.; Kostevich, V.; Kudryavtsev, I.; Syromiatnikova, E.; Vasilyev, V.; Cherenkevich, S.; Panasenko, O.
Neutrophil activation in response to monomeric myeloperoxidase
Biochem. Cell Biol.
96
592-601
2018
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Vakhrusheva, T.; Sokolov, A.; Kostevich, V.; Vasilyev, V.; Panasenko, O.
Enzymatic and bactericidal activity of monomeric and dimeric forms of myeloperoxidase
Biochemistry (Moscow) Suppl. Ser. B
12
258-265
2018
Homo sapiens
-
Manually annotated by BRENDA team
Santos, M.B.D.; Carvalho Marques, B.; Miranda Ayusso, G.; Rocha Garcia, M.A.; Chiquetto Paracatu, L.; Pauli, I.; Silva Bolzani, V.; Defini Andricopulo, A.; Farias Ximenes, V.; Zeraik, M.L.; Regasini, L.O.
Chalcones and their B-aryl analogues as myeloperoxidase inhibitors In silico, in vitro and ex vivo investigations
Bioorg. Chem.
110
104773
2021
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Shaw, S.A.; Vokits, B.P.; Dilger, A.K.; Viet, A.; Clark, C.G.; Abell, L.M.; Locke, G.A.; Duke, G.; Kopcho, L.M.; Dongre, A.; Gao, J.; Krishnakumar, A.; Jusuf, S.; Khan, J.; Spronk, S.A.; Basso, M.D.; Zhao, L.; Cantor, G.H.; Onorato, J.M.; Wexler, R.R.; Duclos, F.; Kick, E.K.
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase
Bioorg. Med. Chem.
28
115723
2020
Homo sapiens (P05164)
Manually annotated by BRENDA team
Hu, C.H.; Neissel Valente, M.W.; Halpern, O.S.; Jusuf, S.; Khan, J.A.; Locke, G.A.; Duke, G.J.; Liu, X.; Duclos, F.J.; Wexler, R.R.; Kick, E.K.; Smallheer, J.M.
Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO)
Bioorg. Med. Chem. Lett.
42
128010
2021
Homo sapiens
Manually annotated by BRENDA team
Jin, Z.; Zhou, L.; Tian, R.; Lu, N.
Myeloperoxidase targets apolipoprotein A-I for site-specific tyrosine chlorination in atherosclerotic lesions and generates dysfunctional high-density lipoprotein
Chem. Res. Toxicol.
34
1672-1680
2021
Homo sapiens
Manually annotated by BRENDA team
Noia, M.; Fontenla-Iglesias, F.; Valle, A.; Blanco-Abad, V.; Leiro, J.M.; Lamas, J.
Characterization of the turbot Scophthalmus maximus (L.) myeloperoxidase. An insight into the evolution of vertebrate peroxidases
Dev. Comp. Immunol.
118
103993
2021
Scophthalmus maximus
Manually annotated by BRENDA team
Thai, T.; Zhong, F.; Dang, L.; Chan, E.; Ku, J.; Malle, E.; Geczy, C.L.; Keaney, J.F.; Thomas, S.R.
Endothelial-transcytosed myeloperoxidase activates endothelial nitric oxide synthase via a phospholipase C-dependent calcium signaling pathway
Free Radic. Biol. Med.
166
255-264
2021
Homo sapiens (P05164)
Manually annotated by BRENDA team
Reiding, K.; Franc, V.; Huitema, M.; Brouwer, E.; Heeringa, P.; Heck, A.
Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation
J. Biol. Chem.
294
20233-20245
2019
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Aggarwal, G.; May-Zhang, L.S.; Yermalitsky, V.; Dikalov, S.; Voynov, M.A.; Amarnath, V.; Kon, V.; Linton, M.F.; Vickers, K.C.; Davies, S.S.
Myeloperoxidase-induced modification of HDL by isolevuglandins inhibits paraoxonase-1 activity
J. Biol. Chem.
297
101019
2021
Homo sapiens (P05164)
Manually annotated by BRENDA team
Zhao, X.; Lin, S.; Li, H.; Si, S.; Wang, Z.
Myeloperoxidase controls bone turnover by suppressing osteoclast differentiation through modulating reactive oxygen species level
J. Bone Miner. Res.
36
591-603
2021
Mus musculus (P11247), Mus musculus
Manually annotated by BRENDA team
Shamova, E.; Gorudko, I.; Grigorieva, D.; Sokolov, A.; Kokhan, A.; Melnikova, G.; Yafremau, N.; Gusev, S.; Sveshnikova, A.; Vasilyev, V.; Cherenkevich, S.; Panasenko, O.
The effect of myeloperoxidase isoforms on biophysical properties of red blood cells
Mol. Cell. Biochem.
464
119-130
2020
Homo sapiens (P05164)
Manually annotated by BRENDA team
Rivera-Antonio, A.; Rosales-Hernandez, M.C.; Balbuena-Rebolledo, I.; Santiago-Quintana, J.M.; Mendieta-Wejebe, J.E.; Correa-Basurto, J.; Garcia-Vazquez, J.B.; Garcia-Baez, E.V.; Padilla-Martinez, I.I.
Myeloperoxidase inhibitory and antioxidant activities of (E)-2-hydroxy-alpha-aminocinnamic acids obtained through microwave-assisted synthesis
Pharmaceuticals
14
513
2021
Homo sapiens (P05164), Homo sapiens
Manually annotated by BRENDA team
Davies, M.J.
Myeloperoxidase Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases
Pharmacol. Ther.
218
107685
2021
Homo sapiens (P05164)
Manually annotated by BRENDA team
Beckmann, L.; Voigtlaender, M.; Rolling, C.C.; Schulenkorf, A.; Bokemeyer, C.; Langer, F.
Myeloperoxidase has no effect on the low procoagulant activity of silica-free DNA
Thromb. Res.
203
36-45
2021
Homo sapiens (P05164)
Manually annotated by BRENDA team