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1.11.1.B2: chloride peroxidase (vanadium-containing)

This is an abbreviated version!
For detailed information about chloride peroxidase (vanadium-containing), go to the full flat file.

Word Map on EC 1.11.1.B2

Reaction

RH
+
Cl-
+
H2O2
+
H+
=
RCl
+ 2 H2O

Synonyms

chloroperoxidase, CPO, Mcl24, More, NapH1, PPHY, V-containing-haloperoxidase, vanadium chloroperoxidase, vanadium haloperoxidase, vanadium-containing chloroperoxidase, vanadium-containing peroxidase, vanadium-dependent chloroperoxidase, vanadium-dependent haloperoxidase, vCPO, VHPO

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.B2 chloride peroxidase (vanadium-containing)

Inhibitors

Inhibitors on EC 1.11.1.B2 - chloride peroxidase (vanadium-containing)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
azide
Br-
inhibition of mutant enzyme S402A between pH 3.5 and 4.5: concentrations greater than 0.2 mM inhibit, between pH 5.0 and 5.5: concentrations above 0.5 mM inhibit, between pH 6.0 and 6.3: 0.5 mM does not inhibit the mutant enzyme
Cl-
pH 4.1: mixed type inhibition with respect to H2O2, pH 3.1: competitive inhibition
H2O2
-
above 50 mM
hydrazine
uncompetitive; uncompetitive inhibition, inhibition constant: 0.3 mM
hydroxylamine
competitive and uncompetitive inhibition; inhibits rVCPO both competitively and uncompetitively. The competitive inhibition constant: 0.04 mM, uncompetitive inhibition 0.08 mM
KCN
-
0.01 mM, 50% inhibition
NO3-
pH 5.5: competitive inhibition of the chlorination reaction with respect to chloride, uncompetitive with respect to H2O2
phosphate
[Fe(CN)6]4-
-
0.7 mM, 50% inhibition of brominating activity
[Fe(CN6)]3-
-
0.82 mM, 50% inhibition of brominating activity