1.11.1.17: glutathione amide-dependent peroxidase

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For detailed information about glutathione amide-dependent peroxidase, go to the full flat file.

Reaction

2 glutathione amide +

Synonyms

garB, More, Prx-containing peroxidase, Prx/Grx chimeric enzyme

ECTree

     1 Oxidoreductases

         1.11 Acting on a peroxide as acceptor

             1.11.1 Peroxidases

                1.11.1.17 glutathione amide-dependent peroxidase

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Results	in table
19	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
1	Cofactor
2	General Information
1	kcat/KM [mM/s]
1	KM Value [mM]
2	Molecular Weight [Da]
2	Organism
1	Pathway
1	pH Optimum
1	Purification (Commentary)
1	Reaction
2	Reference
2	Substrates and Products (Substrate)
7	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.11.1.17 - glutathione amide-dependent peroxidase

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SYSTEMATIC NAME

IUBMB Comments

glutathione amide:hydrogen-peroxide oxidoreductase

This enzyme, which has been characterized from the proteobacterium Marichromatium gracile, is a chimeric protein, containing a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus. The enzyme has peroxidase activity towards hydrogen peroxide and several small alkyl hydroperoxides, and is thought to represent an early adaptation for fighting oxidative stress [1]. The glutathione amide disulfide produced by this enzyme can be restored to glutathione amide by EC 1.8.1.16 (glutathione amide reductase).