1.11.1.12: phospholipid-hydroperoxide glutathione peroxidase

This is an abbreviated version!
For detailed information about phospholipid-hydroperoxide glutathione peroxidase, go to the full flat file.

Word Map on EC 1.11.1.12

1.11.1.12

selenoproteins

ferroptosis

gsh

thioredoxin

testis

iron-dependent

selenite

dismutase

malondialdehyde

catalase

selenoenzyme

sod

hepatokine

micronutrient

iodothyronine

deiodinase

selenomethionine

se-deficient

selenium-containing

erastin

secis

selenium-deficient

non-apoptotic

ferrostatin-1

spermatozoa

se-dependent

se-adequate

apoer2

analysis

na2seo3

midpiece

selenocysteine-containing

se-containing

slc7a11

medicine

ferroptosis-related

5'-deiodinase

deferoxamine

selenocompounds

15-lipoxygenase

ebselen

txnrd1

hydroperoxy

gsh-px

torula

peroxidase-1

se-enriched

biomembranes

loohs

iron-mediated

liver-derived

hydroperoxidase

Reaction

2 glutathione +

Synonyms

AC-PHGPx, Bi-PHGPx, class 4 GPx, CsGPx1, CsGPx2, CsGPx3, CsGPx4, DMPHGPx, glutathione peroxidase 4, glutathione peroxidase-4, glutathione-dependent phospholipid peroxidase, GPX, GPx-4, GPX3, GPx4, GPx41, GPx4A, GPx4B, GPXhs2, GPXle1, hydroperoxide glutathione peroxidase, Hyr1, Hyr1/YIR037W, McPHGPx, More, non-selenocysteine PHGPx, NPGPx, nPHGPx, OsPHGPx, peroxidation-inhibiting protein, peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing), PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase A, phospholipid hydroperoxide glutathione peroxidase B, phospholipid hydroperoxide glutathione peroxidase-4, phospholipid-hydroperoxide glutathione peroxidase, selenium-dependent glutathione peroxidase type-4, seleno GPx, selenoperoxidase, selenoprotein P, sperm nucleus-specific glutathione peroxidase, TTHERM_00661720, type-4 glutathione peroxidase, VcPHGPx

ECTree

1 Oxidoreductases

1.11 Acting on a peroxide as acceptor

1.11.1 Peroxidases

1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase

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Results	in table
10	Activating Compound
39	AA Sequence
8	Application
1	CAS Registry Number
32	Cloned(Commentary)
14	Cofactor
7	Crystallization (Commentary)
1078	Disease/ Diagnostics
11	Expression
15	General Information
2	General Stability
13	Inhibitors
1	Ki Value [mM]
23	KM Value [mM]
58	Localization
25	Metals/Ions
32	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
96	Organism
13	Pathway
15	PDB ID
23	pH Optimum
4	pH Range
1	pI Value
1	Posttranslational Modification
23	Protein Variants
28	Purification (Commentary)
6	Reaction
29	Reaction Type
92	Reference
218	Source Tissue
51	Specific Activity [micromol/min/mg]
3	Storage Stability
200	Substrates and Products (Substrate)
29	Subunits
155	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
4	Temperature Range [°C]
3	Temperature Stability [°C]
5	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.11.1.12 - phospholipid-hydroperoxide glutathione peroxidase

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(1S,3R)-RSL3

2 entries

2-chloro-N-(3-chloro-4-methoxyphenyl)-N-[(1S)-2-(phenylethylethylamino)-2-oxo-1-(thiophen-2-yl)ethyl]acetamide

i.e. ML162

alpha-tocopherol

complete inhibition of glutathione oxidation

deoxycholate

ferrostatin-1

along with the prevention of beta-cell death, siGPx4-mediated induction of lipid peroxidation and ATP depletion are reduced significantly in the presence of ferroptosis inhibitor ferrostatin-1 at 0.001 mM

iodoacetate

Mercaptosuccinate

0.1 mM

RSL3

a selective GPx4 inhibitor, mediates concentration-dependent inhibition of GPX4, lipid peroxidation, enhanced mitochondrial fragmentation, loss of mitochondrial membrane potential, and reduced mitochondrial respiration. Ferroptosis inhibitors, such as deferoxamine, ferrostatin-1 and liproxstatin-1, but also CRISPR/Cas9 Bid knockout and the BID inhibitor BI-6c9 protect against RSL3 toxicity. Cell toxicity of the different RSL3 isomers in HT22 wild-type cells, overview

764701

unsaturated fatty acids

Sus scrofa

394865