1.11.1.12: phospholipid-hydroperoxide glutathione peroxidase

This is an abbreviated version!
For detailed information about phospholipid-hydroperoxide glutathione peroxidase, go to the full flat file.

Reaction

2 glutathione +

Synonyms

AC-PHGPx, Bi-PHGPx, class 4 GPx, CsGPx1, CsGPx2, CsGPx3, CsGPx4, DMPHGPx, glutathione peroxidase 4, glutathione peroxidase-4, glutathione-dependent phospholipid peroxidase, GPX, GPx-4, GPX3, GPx4, GPx41, GPx4A, GPx4B, GPXhs2, GPXle1, hydroperoxide glutathione peroxidase, Hyr1, Hyr1/YIR037W, McPHGPx, More, non-selenocysteine PHGPx, NPGPx, nPHGPx, OsPHGPx, peroxidation-inhibiting protein, peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing), PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase A, phospholipid hydroperoxide glutathione peroxidase B, phospholipid hydroperoxide glutathione peroxidase-4, phospholipid-hydroperoxide glutathione peroxidase, selenium-dependent glutathione peroxidase type-4, seleno GPx, selenoperoxidase, selenoprotein P, sperm nucleus-specific glutathione peroxidase, TTHERM_00661720, type-4 glutathione peroxidase, VcPHGPx

ECTree

     1 Oxidoreductases

         1.11 Acting on a peroxide as acceptor

             1.11.1 Peroxidases

                1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase

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Results	in table
10	Activating Compound
39	AA Sequence
8	Application
1	CAS Registry Number
32	Cloned(Commentary)
14	Cofactor
7	Crystallization (Commentary)
1078	Disease/ Diagnostics
11	Expression
15	General Information
2	General Stability
13	Inhibitors
1	Ki Value [mM]
23	KM Value [mM]
58	Localization
25	Metals/Ions
32	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
96	Organism
13	Pathway
15	PDB ID
23	pH Optimum
4	pH Range
1	pI Value
1	Posttranslational Modification
23	Protein Variants
28	Purification (Commentary)
6	Reaction
29	Reaction Type
92	Reference
218	Source Tissue
51	Specific Activity [micromol/min/mg]
3	Storage Stability
200	Substrates and Products (Substrate)
29	Subunits
155	Synonyms
1	Systematic Name
18	Temperature Optimum [°C]
4	Temperature Range [°C]
3	Temperature Stability [°C]
5	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 1.11.1.12 - phospholipid-hydroperoxide glutathione peroxidase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

17-beta-estradiol

Bos taurus

Q9N2J2

causes increase in GPx-4 activity

673343

9-hydroperoxy-10E,12Z-octadecadienoic acid

Homo sapiens

P36969

9-HpODE, induces a dose-dependent intracellular increase in GSH oxidation that is independent of intracellular H2O2 production and is mediated by glutathione peroxidase 4 (GPx4) in BEAS-2B cells. Glucose deprivation potentiates the oxidative effect of 9-HpODE on GSH and inhibits its recovery

764204

-

deoxycholate

Homo sapiens

-

activity is slightly enhanced, but is enhanced by 50% together with Triton X-100

394873

H2O2

Oryza sativa

-

-

701033

NaCl

Oryza sativa

-

-

701033

selenoprotein P

Homo sapiens

-

2 nM, 3fold stimulation of activity after 24h

673807

-

Sodium selenite

Homo sapiens

-

100 nM, 3fold stimulation of activity after 24h

673807

Triton X-100

2 entries

Triton X-100

Homo sapiens

-

-

394873

Triton X-100

Sus scrofa

-

-

394864, 394865