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1.10.3.2: laccase

This is an abbreviated version!
For detailed information about laccase, go to the full flat file.

Word Map on EC 1.10.3.2

Reaction

4 benzenediol +

O2
= 4 benzosemiquinone + 2 H2O

Synonyms

ATM, benzenediol oxygen oxidoreductase, benzenediol-oxygen oxidoreductase, benzenediol: oxygen oxidoreductase, benzenediol:O2 oxidoreductase, Benzenediol:oxygen oxidoreductase, blue laccase, blue multicopper oxidase, CcLCC6, CotA, CotA laccase, CotA-laccase, CotA-type laccase, CueO, DA2_0547, DcLac1, DcLac2, Diphenol oxidase, EpoA, Ery4, Ery4 laccase, FpLcc1, FpLcc2, GMET_RS10855, Hvo_B0205, LAC, Lac I, Lac II, Lac-3.5, Lac-4.8, LAC1, Lac2, Lac2a, LAC3, Lac4, LacA, Lacc, laccase, laccase 1, laccase 3, laccase A, Laccase allele OR, Laccase allele TS, laccase CueO, laccase POXA3b, laccase-2, laccase2, LacCh, lacTT, LacTv, LacZ1, Lcc, lcc1, Lcc2, Lcc3, Lcc4, Lcc9, LccA, lccdelta, lccgamma, Ligninolytic phenoloxidase, MAL, McoP, MmPPO laccase, MmPPOA, More, MSK laccase, multicopper oxidase, p-benzenediol:dioxygen oxidoreductase, p-diphenol dioxygen oxidoreductase, p-diphenol oxidase, p-diphenol: dioxygen oxidoreductase, p-diphenol:dioxygenoxidoreductase, p-diphenol:O2 oxidoreductase, p-diphenol:oxygen oxidoreductase, p-diphenol:oxygen-oxidoreductase, PCL, phenol oxidase, PM1 laccase, polyphenol oxidase A, POXA1b, POXA1w, POXA2, POXA3 laccase, POXA3a, POXA3b, POXC, PpoA, PsLac1, PsLac2, rlac1338, SLAC, SN4LAC, spore coat A protein, spore coat protein A, SRL1, SvLAC13, SvLAC15, SvLAC50, SvLAC52, SvLAC9, TaLac1, ThL, TTC1370, TthLAC, two-domain laccase, urishiol oxidase, urushiol oxidase, Wlac, YacK, yellow laccase

ECTree

     1 Oxidoreductases
         1.10 Acting on diphenols and related substances as donors
             1.10.3 With oxygen as acceptor
                1.10.3.2 laccase

pH Range

pH Range on EC 1.10.3.2 - laccase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.5 - 8
-
activity range
2 - 10
MK290990.1
pH 2.0: about 70% of maximal activity, pH 10.0: about 80% of maximal activity
2 - 11
for pH ranges between pH 2 and pH 11 enzyme activity ranges between 75 and 100%
2 - 12
-
the purified laccase maintains stable at pH 3.0-11.0. The enzyme remains active at pH values from 3.0 to 12.0, and its activity at pH 2.0 and 12.0 are 56.6% and 85.5% of that at pH 7.0, respectively
2 - 5
2 - 5.5
Myrioconium sp.
-
pH 2.0: about 65% of maximal activity, pH 5.5: about 45% of maximal activity, oxidation of 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonate)
2 - 6
2 - 7
activity range, profile, overview
2 - 8
2.2 - 4.2
2.2 - 4.3
-
pH 2.2: about 90% of maximal activity, pH 4.3: about 60% of maximal activity, substrate: 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid)
2.2 - 5
-
activity range
2.3 - 4
pH 2.3: about 40% of maximal activity, pH 4.0: about 75% of maximal activity
2.5 - 5
2.5 - 5.5
-
inactivation of isozyme Lacc I at pH 6.5, of isozyme Lacc II at pH 7.5
2.5 - 6.5
-
3% of maximal activity at pH 6.5, pH-activity profile at 30°C
3 - 10
3 - 11
Sporothrix carnis
-
pH 3.0: 93% of maximal activity, pH 11.0: 91% of maximal activity
3 - 4
3 - 6
3 - 6.4
pH profile with substrate 2,6-dimethoxyphenol
3 - 6.5
3 - 7
3 - 8
3 - 9
recombinant wild-type enzyme, active range and broad optimum
3.5 - 4.5
-
pH 3.5: about 55% of maximal activity, pH 4.5: about 60% of maximal activity, substrate: 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid)
3.5 - 5
-
pH 3.5: about 70% of maximal activity, pH 5.0: about 70% of maximal activity
3.5 - 5.5
3.5 - 9
-
-
3.7 - 8
-
-
4 - 10
-
activity range, 60-65% of maximal activity at pH 4.0 and pH 10.0, profile, overview
4 - 5
-
depends on substrate
4 - 5.5
-
substrate 2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)
4 - 6
-
pH 4.0: about 70% of maximal activity, pH 6.0: about 85% of maximal activity, substrate: 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid)
4 - 7
pH 4.0: about 35% of maximal activity, pH 7.0: about 55% of maximal activity, substrate: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)
4 - 8
4 - 9
4.5 - 11
-
activity range
4.5 - 5.5
Thermochaetoides thermophila
-
-
4.5 - 7.3
5
-
decline of activity above
5 - 8
5 - 8.5
-
pH 5.0: about 50% of maximal activity, pH 8.5: about 50% of maximal activity, substrate: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)
5.1
no activity with substrate [Cu(I)(bicinchoninate)2]3-
5.5 - 6.5
Myrioconium sp.
-
pH 5.5: about 90% of maximal activity, pH 6.5: about 60% of maximal activity, oxidation of syringaldazine
5.5 - 8.5
-
pH 5.5: about 75% of maximal activity, pH 8.5: about 50% of maximal activity, substrate: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)
6 - 7.5
6 - 8
6 - 9
6.2 - 6.5
-
substrate syringaldazine
6.5
-
no enzymatic activity above
7.5 - 8.5
-
pH 7.5: about 45% of maximal activity, pH 8.5: about 35% of maximal activity, substrate: 2,6-dimethoxyphenol
7.5 - 9
-
pH 7.5: about 65% of maximal activity, pH 9.0: 72% of maximal activity
8
-
no enzymic activity above
8 - 11.5
-
retains more than 80% of activity after 17 h in this pH-range
additional information