1.10.3.2: laccase

This is an abbreviated version!
For detailed information about laccase, go to the full flat file.

Reaction

4 benzenediol +

Synonyms

ATM, benzenediol oxygen oxidoreductase, benzenediol-oxygen oxidoreductase, benzenediol: oxygen oxidoreductase, benzenediol:O2 oxidoreductase, Benzenediol:oxygen oxidoreductase, blue laccase, blue multicopper oxidase, CcLCC6, CotA, CotA laccase, CotA-laccase, CotA-type laccase, CueO, DA2_0547, DcLac1, DcLac2, Diphenol oxidase, EpoA, Ery4, Ery4 laccase, FpLcc1, FpLcc2, GMET_RS10855, Hvo_B0205, LAC, Lac I, Lac II, Lac-3.5, Lac-4.8, LAC1, Lac2, Lac2a, LAC3, Lac4, LacA, Lacc, laccase, laccase 1, laccase 3, laccase A, Laccase allele OR, Laccase allele TS, laccase CueO, laccase POXA3b, laccase-2, laccase2, LacCh, lacTT, LacTv, LacZ1, Lcc, lcc1, Lcc2, Lcc3, Lcc4, Lcc9, LccA, lccdelta, lccgamma, Ligninolytic phenoloxidase, MAL, McoP, MmPPO laccase, MmPPOA, More, MSK laccase, multicopper oxidase, p-benzenediol:dioxygen oxidoreductase, p-diphenol dioxygen oxidoreductase, p-diphenol oxidase, p-diphenol: dioxygen oxidoreductase, p-diphenol:dioxygenoxidoreductase, p-diphenol:O2 oxidoreductase, p-diphenol:oxygen oxidoreductase, p-diphenol:oxygen-oxidoreductase, PCL, phenol oxidase, PM1 laccase, polyphenol oxidase A, POXA1b, POXA1w, POXA2, POXA3 laccase, POXA3a, POXA3b, POXC, PpoA, PsLac1, PsLac2, rlac1338, SLAC, SN4LAC, spore coat A protein, spore coat protein A, SRL1, SvLAC13, SvLAC15, SvLAC50, SvLAC52, SvLAC9, TaLac1, ThL, TTC1370, TthLAC, two-domain laccase, urishiol oxidase, urushiol oxidase, Wlac, YacK, yellow laccase

ECTree

     1 Oxidoreductases

         1.10 Acting on diphenols and related substances as donors

             1.10.3 With oxygen as acceptor

                1.10.3.2 laccase

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Results	in table
42	Activating Compound
8855	AA Sequence
203	Application
1	CAS Registry Number
106	Cloned(Commentary)
19	Crystallization (Commentary)
9	Expression
48	General Information
17	General Stability
13	IC50 Value
803	Inhibitors
257	kcat/KM [mM/s]
15	Ki Value [mM]
741	KM Value [mM]
108	Localization
333	Metals/Ions
243	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
124	Organic Solvent Stability
616	Organism
4	Pathway
349	PDB ID
358	pH Optimum
93	pH Range
164	pH Stability
67	pI Value
81	Posttranslational Modification
162	Protein Variants
204	Purification (Commentary)
9	Reaction
3	Reaction Type
583	Reference
8	Renatured (Commentary)
176	Source Tissue
196	Specific Activity [micromol/min/mg]
19	Storage Stability
1635	Substrates and Products (Substrate)
249	Subunits
318	Synonyms
1	Systematic Name
221	Temperature Optimum [°C]
75	Temperature Range [°C]
317	Temperature Stability [°C]
505	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.10.3.2 - laccase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

4 catechol + O2

4 1,2-benzoquinone + 2 H2O

11 entries

DOPA + O2

? + H2O

Cryptococcus neoformans

-

the enzyme laccase catalyses the formation of melanin by oxidizing L-DOPA, initiating a series of presumably spontaneous reactions that ultimately leads to the polymerization of the pigment in the yeast cell wall. There, melanin protects the cell from a multitude of environmental and host assaults. Kinetics of dopachrome formation are similar for L- and D-DOPA

688867

-

-

?

melanin + O2

?

Phlebia radiata

-

the enzyme decolorizes fungal melanin from Alternaria alternata strain NBCR 31805 or black hyphae of Cladosporium sp. strain B-1, but not synthetic melanin, overview

696857

-

-

?

poly R-478 + O2

?

12 entries

additional information

?

-

24 entries

4 catechol + O2

4 1,2-benzoquinone + 2 H2O

Cerrena sp. WR1

E7BLR0

-

726424

-

-

?

4 catechol + O2

4 1,2-benzoquinone + 2 H2O

Hericium coralloides

-

-

725692

-

-

?

4 catechol + O2

4 1,2-benzoquinone + 2 H2O

Melanocarpus albomyces

-

-

724417

-

-

?

4 catechol + O2

4 1,2-benzoquinone + 2 H2O

Toxicodendron vernicifluum

Q8H979

-

724417

-

-

?

4 catechol + O2

4 1,2-benzoquinone + 2 H2O

Trametes hirsuta

Q02497

-

724417

-

-

?

4 catechol + O2

4 1,2-benzoquinone + 2 H2O

Trametes hirsuta VTT D-95443

Q02497

-

724417

-

-

?

4 catechol + O2

4 1,2-benzoquinone + 2 H2O

Trametes polyzona

-

-

725302

-

-

?

4 catechol + O2

4 1,2-benzoquinone + 2 H2O

Trametes polyzona WR710-1

-

-

725302

-

-

?

4 catechol + O2

4 1,2-benzoquinone + 2 H2O

Trametes sp.

-

-

726534

-

-

?

4 catechol + O2

4 1,2-benzoquinone + 2 H2O

Trametes sp. BS54

-

-

726534

-

-

?

4 catechol + O2

4 1,2-benzoquinone + 2 H2O

Trametes versicolor

-

-

724417

-

-

?

poly R-478 + O2

?

Kamptonema formosum

-

dye decolorization activity

701411

-

-

?

poly R-478 + O2

?

Leptolyngbya valderiana

-

dye decolorization activity

701411

-

-

?

poly R-478 + O2

?

Oscillatoria subuliformis

-

dye decolorization activity

701411

-

-

?

poly R-478 + O2

?

Oscillatoria subuliformis BDU100712

-

dye decolorization activity

701411

-

-

?

poly R-478 + O2

?

Phormidium boryanum

-

dye decolorization activity

701411

-

-

?

poly R-478 + O2

?

Phormidium boryanum BDU92181

-

dye decolorization activity

701411

-

-

?

poly R-478 + O2

?

Phormidium chlorinum

-

dye decolorization activity

701411

-

-

?

poly R-478 + O2

?

Phormidium chlorinum BDU140691

-

dye decolorization activity

701411

-

-

?

poly R-478 + O2

?

Phormidium tenue

-

dye decolorization activity

701411

-

-

?

poly R-478 + O2

?

Phormidium tenue BDU60591

-

dye decolorization activity

701411

-

-

?

poly R-478 + O2

?

Phormidium willei

-

dye decolorization activity

701411

-

-

?

poly R-478 + O2

?

Phormidium willei BDU130511

-

dye decolorization activity

701411

-

-

?

additional information

?

-

Coriolopsis rigida

-

involved in production of oxygen free radicals

396396

-

-

?

additional information

?

-

Embryophyta

-

involved in decomposition of lignin, discussion of physiological role

396341

-

-

?

additional information

?

-

Fungi

-

involved in decomposition of lignin, discussion of physiological role

396341

-

-

?

additional information

?

-

Lentinula edodes

-

involved in melanin synthesis

656729

-

-

?

additional information

?

-

Phoma sp.

B3TLA6

laccases are able to oxidize a variety of substrates, ranging from mono- and polyphenols over aminophenols, methoxyphenols and aromatic amines to polycyclic aromatic hydrocarbons and certain lignin moieties

695839

-

-

?

additional information

?

-

Phoma sp.

-

laccases are able to oxidize a variety of substrates, ranging from mono- and polyphenols over aminophenols, methoxyphenols and aromatic amines to polycyclic aromatic hydrocarbons and certain lignin moieties

695839

-

-

?

additional information

?

-

Phoma sp. UHH 5-1-03 / DSM 22425

B3TLA6

laccases are able to oxidize a variety of substrates, ranging from mono- and polyphenols over aminophenols, methoxyphenols and aromatic amines to polycyclic aromatic hydrocarbons and certain lignin moieties

695839

-

-

?

additional information

?

-

Pleurotus eryngii

-

the laccase exhibits an inhibitory activity toward HIV-1 reverse transcriptase with an IC50 of 0.0022 mM

671513

-

-

?

additional information

?

-

Pleurotus eryngii

A9UC95

the genes encoding the laccacse isozymes are differently regulated, overview

700336

-

-

?

additional information

?

-

Pleurotus eryngii

A9UC97

the genes encoding the laccacse isozymes are differently regulated, overview

700336

-

-

?

additional information

?

-

Pleurotus eryngii

A9UC99

the genes encoding the laccacse isozymes are differently regulated, overview

700336

-

-

?

additional information

?

-

Pleurotus eryngii

A9UCA1

the genes encoding the laccacse isozymes are differently regulated, overview

700336

-

-

?

additional information

?

-

Pleurotus eryngii

-

the genes encoding the laccacse isozymes are differently regulated, overview

700336

-

-

?

additional information

?

-

Pleurotus eryngii var. ferulae

A9UC96

the genes encoding the laccacse isozymes are differently regulated, overview

700336

-

-

?

additional information

?

-

Pleurotus eryngii var. ferulae

A9UC98

the genes encoding the laccacse isozymes are differently regulated, overview

700336

-

-

?

additional information

?

-

Pleurotus eryngii var. ferulae

A9UCA0

the genes encoding the laccacse isozymes are differently regulated, overview

700336

-

-

?

additional information

?

-

Pleurotus eryngii var. ferulae

A9UCA2

the genes encoding the laccacse isozymes are differently regulated, overview

700336

-

-

?

additional information

?

-

Pleurotus ostreatus

-

the enzyme catalyzes the oxidation of a wide range of compounds, including poly-phenols and anilines. The one electron oxidation of the reducing substrate occurs concomitantly with the four-electron reduction of molecular oxygen to water

726532

-

-

?

additional information

?

-

Thermus thermophilus

-

the enzyme oxidizes a range of phenolic and nonphenolic compounds using molecular oxygen as an electron acceptor to produce water with a broad substrate specificity

695374

-

-

?

additional information

?

-

Trametes sanguinea

-

laccase couples catalytic oxidation of lignin with the four electron reduction of oxygen, the final product is water without any harmful intermediate making laccase the best candidate for the environmentally benign bleaching process

671560

-

-

?

additional information

?

-

Trametes sanguinea CCT-4518

-

laccase couples catalytic oxidation of lignin with the four electron reduction of oxygen, the final product is water without any harmful intermediate making laccase the best candidate for the environmentally benign bleaching process

671560

-

-

?

additional information

?

-

Trametes versicolor

Q5IR80

the enzyme is involved in bioremdiation

673713

-

-

?

additional information

?

-

Trametes versicolor

-

the enzyme is involved in bioremdiation

673713

-

-

?

additional information

?

-

Trametes versicolor UAMH 8272

Q5IR80

the enzyme is involved in bioremdiation

673713

-

-

?