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2,6-dihydroxy-4-[[(2E,6E,10E)-12-hydroxy-2,6,10-trimethyldodeca-2,6,10-trien-1-yl]oxy]benzoic acid
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2-fluoro-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoic acid
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2-heptyl-4-hydroxyquinoline N-oxide
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i.e. HQNO, binds stoichiometrically to the enzyme and prevents formation of the ubisemiquinone at the QH-site, but does not displace the ubiquinone-8 bound at the QH-site, enzyme binding kineticss, overview
2-Heptyl-4-hydroxyquinoline-N-oxide
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2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]-6-methylbenzoic acid
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2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoic acid
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2-hydroxybenzhydroxamic acid
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competitive inhibitor towards ubiquinol
4-[(14-bromotetradecyl)oxy]-2-hydroxybenzaldehyde
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4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]-2-methylbenzoic acid
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5-chloro-3-[(2E)-3,7-dimethylocta-2,6-dienyl]-2,4-dihydroxy-6-methylbenzaldehyde
an ascofuranone derivative
5-chloro-3-[(2E,6E)-8-hydroxy-3,7-dimethylnona-2,6-dienyl]-2,4-dihydroxy-6-methylbenzaldehyde
an ascofuranone derivative
antimycin A
56% residual activity at 0.005 mg/ml; 56% residual activity at 0.005 mg/ml
aurachin C 1-10
15% residual activity at 0.005 mg/ml; 15% residual activity at 0.005 mg/ml
aurachin C1-10
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prevents formation of the ubisemiquinone at the QH-site, but appears to compete for quinol binding at the QL-site, enzyme binding kineticss, overview
aurachin D
16% residual activity at 0.005 mg/ml; 16% residual activity at 0.005 mg/ml
ferulenol
competitive inhibitor, binding is completely reversible
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Gramicidin S
67% residual activity at 0.005 mg/ml; 67% residual activity at 0.005 mg/ml
LL-Z1272gamma
69% residual activity at 0.005 mg/ml; 69% residual activity at 0.005 mg/ml
methyl 2-hydroxy-4-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dien-1-yl]oxy]benzoate
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methyl 4-[(14-bromotetradecyl)oxy]-2-hydroxybenzoate
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Piericidin A
14% residual activity at 0.005 mg/ml; 14% residual activity at 0.005 mg/ml
salicylic hydroxamic acid
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ubiquinol-1
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substrate inhibition
ubiquinol-2
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substrate inhibition
ubiquinone-1
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product inhibition, an excess amount of ubiquinol-2 is unable to suppress product inhibition with ubiquinone-1 therefore, the inhibition mode may not be competitive
ubiquinone-2
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product inhibition
[14-(4-carboxy-3-hydroxy-5-methylphenoxy)tetradecyl](triphenyl)phosphanium
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[14-(4-formyl-3-hydroxyphenoxy)tetradecyl](triphenyl)phosphanium
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[14-[3-fluoro-4-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium
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[14-[3-hydroxy-4-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium
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[14-[4-(ethoxycarbonyl)-3-hydroxy-5-methylphenoxy]tetradecyl](triphenyl)phosphanium
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[14-[4-hydroxy-3-(methoxycarbonyl)phenoxy]tetradecyl](triphenyl)phosphanium
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ascochlorin
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ascofuranone
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almost complete inhibition at 10 nM
ascofuranone
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almost complete inhibition at 10 nM
ascofuranone
an antibiotic
ascofuranone
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specifically inhibits the quinol oxidase activity of TAO
ascofuranone
quasi-irreversible inhibitor
colletochlorin B
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mixed-type inhibitor
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cyanide
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cyanide
quinol oxidase activity of the membranes from the wild type shows a biphasic dependence on the cyanide concentration; quinol oxidase activity of the membranes from the wild type shows a biphasic dependence on the cyanide concentration
n-octyl gallate
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the enzyme is fully sensitive to 0.001 mM octyl gallate
n-octyl gallate
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the enzyme is fully sensitive to 0.001 mM octyl gallate
n-propyl gallate
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octyl gallate
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octylgallate
weak inhibition
octylgallate
weak inhibition
Salicylhydroxamic acid
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Salicylhydroxamic acid
weak inhibition
Salicylhydroxamic acid
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Salicylhydroxamic acid
weak inhibition
ubiquinol
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AOX is inactivated by its product ubiquinol during catalysis, this inhibition is prevented in the presence of pyruvate. The inhibition can be reversed by a reductive process, achieved by high levels of reduction of the ubiquinone-pool or by dithiothreitol
ubiquinol
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AOX is inactivated by its product ubiquinol during catalysis, this inhibition is prevented in the presence of pyruvate. The inhibition can be reversed by a reductive process, achieved by high levels of reduction of the ubiquinone-pool or by dithiothreitol
additional information
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the enzyme is cyanide- and antimycin-resistant
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additional information
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not inhibited by cyanide
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additional information
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presence of high affinity inhibitors, 2-heptyl-4-hydroxyquinoline N-oxide and aurachin C110, does not displace ubiquinone-8 from the QH site
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additional information
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not inhibited by ascofuranone; not inhibited by ascofuranone
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additional information
not inhibited by ascofuranone; not inhibited by ascofuranone
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additional information
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CIO activity is much more resistant to cyanide, compared with Escherichia coli cytochrome bd, but sensitive to azide
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additional information
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not inhibited by myxothiazol
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additional information
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insensitive to cyanide
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additional information
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the respiratory activity exhibited by mitochondria containing the wild type AOX is partially resistant to antimycin A (about 18% of the NADH-dependent rate)
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additional information
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the enzyme is cyanide- and antimycin-resistant
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additional information
inhibitor binding induces the ligation of a histidine residue in the active site, inhibitor binding site and structures, overview
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additional information
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inhibitor binding induces the ligation of a histidine residue in the active site, inhibitor binding site and structures, overview
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additional information
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insensitive to cyanide
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