1.1.99.7: lactate-malate transhydrogenase
This is an abbreviated version!
For detailed information about lactate-malate transhydrogenase, go to the full flat file.
Reaction
Synonyms
malate-lactate transhydrogenase, transhydrogenase, lactate-malate
ECTree
1.1.99.7 lactate-malate transhydrogenaseAdvanced search results
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Substrates Products on EC 1.1.99.7 - lactate-malate transhydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-lactate + oxaloacetate
malate + pyruvate
-
catalyzes hydrogen transfer from C3 or C4(S)-2-hydroxy acids to 2-oxo-acids, hydrogen donors: L-malate, DL-lactate and DL-alpha-hydroxybutyrate, low activity with: DL-alpha-hydroxyglutarate, DL-alpha-hydroxyvalerate, DL-beta-hydroxybutyrate and DL-alpha-hydroxycaprylate, hydrogen acceptors: oxalacetate, low activity with: alpha-ketoglutarate, alpha-ketocaprylate
-
r
(S)-lactate + oxaloacetate
malate + pyruvate
-
keto-tautomer is the enzymatically active form of oxalacetate
-
r
(S)-lactate + oxaloacetate
malate + pyruvate
-
50% higher specific activity with malate and pyruvate as substrates
-
?
(S)-lactate + oxaloacetate
malate + pyruvate
-
first step in fermentation of lactate
-
?
