1.1.99.39: D-2-hydroxyglutarate dehydrogenase
This is an abbreviated version!
For detailed information about D-2-hydroxyglutarate dehydrogenase, go to the full flat file.
Word Map on EC 1.1.99.39
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1.1.99.39
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acidurias
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neurometabolic
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isocitrate
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2-ketoglutarate
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l2hgdh
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l-2-hga
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d-lactate
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d-malate
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chondromatosis
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metaphyseal
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oncometabolite
- 1.1.99.39
-
acidurias
-
neurometabolic
- isocitrate
- 2-ketoglutarate
- l2hgdh
-
l-2-hga
- d-lactate
- d-malate
- chondromatosis
-
metaphyseal
-
oncometabolite
Reaction
Synonyms
2-hydroxyglutarate dehydrogenase, AtD-2HGDH, D-2-HG dehydrogenase, D-2-HGA, D-2-hydroxyglutarate dehydrogenase, D2-hydroxyglutarate dehydrogenase, D2HDH, D2HGDH
ECTree
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Reference on EC 1.1.99.39 - D-2-hydroxyglutarate dehydrogenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Struys, E.A.; Korman, S.H.; Salomons, G.S.; Darmin, P.S.; Achouri, Y.; van Schaftingen, E.; Verhoeven, N.M.; Jakobs, C.
Mutations in phenotypically mild D-2-hydroxyglutaric aciduria
Ann. Neurol.
58
626-630
2005
Homo sapiens
Engqvist, M.; Drincovich, M.F.; Fluegge, U.I.; Maurino, V.G.
Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways
J. Biol. Chem.
284
25026-25037
2009
Arabidopsis thaliana (O23240), Arabidopsis thaliana
Araujo, W.L.; Ishizaki, K.; Nunes-Nesi, A.; Larson, T.R.; Tohge, T.; Krahnert, I.; Witt, S.; Obata, T.; Schauer, N.; Graham, I.A.; Leaver, C.J.; Fernie, A.R.
Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria
Plant Cell
22
1549-1563
2010
Arabidopsis thaliana
Lin, A.P.; Abbas, S.; Kim, S.W.; Ortega, M.; Bouamar, H.; Escobedo, Y.; Varadarajan, P.; Qin, Y.; Sudderth, J.; Schulz, E.; Deutsch, A.; Mohan, S.; Ulz, P.; Neumeister, P.; Rakheja, D.; Gao, X.; Hinck, A.; Weintraub, S.T.; DeBerardinis, R.J.; Sill, H.; Dahia, P.L.; Aguiar, R.C.
D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2
Nat. Commun.
6
7768
2015
Homo sapiens (Q8N465)
Quaye, J.A.; Gadda, G.
Kinetic and bioinformatic characterization of D-2-hydroxyglutarate dehydrogenase from Pseudomonas aeruginosa PAO1
Biochemistry
59
4833-4844
2020
Pseudomonas aeruginosa (Q9I6H4), Pseudomonas aeruginosa
Toplak, M.; Brunner, J.; Schmidt, J.; Macheroux, P.
Biochemical characterization of human D-2-hydroxyglutarate dehydrogenase and two disease related variants reveals the molecular cause of D-2-hydroxyglutaric aciduria
Biochim. Biophys. Acta
1867
140255
2019
Homo sapiens (Q8N465), Homo sapiens
Guo, X.; Zhang, M.; Cao, M.; Zhang, W.; Kang, Z.; Xu, P.; Ma, C.; Gao, C.
D-2-Hydroxyglutarate dehydrogenase plays a dual role in L-serine biosynthesis and D-malate utilization in the bacterium Pseudomonas stutzeri
J. Biol. Chem.
293
15513-15523
2018
Pseudomonas stutzeri, Pseudomonas stutzeri A1501
Zhang, W.; Zhang, M.; Gao, C.; Zhang, Y.; Ge, Y.; Guo, S.; Guo, X.; Zhou, Z.; Liu, Q.; Zhang, Y.; Ma, C.; Tao, F.; Xu, P.
Coupling between D-3-phosphoglycerate dehydrogenase and D-2-hydroxyglutarate dehydrogenase drives bacterial L-serine synthesis
Proc. Natl. Acad. Sci. USA
114
E7574-E7582
2017
Pseudomonas stutzeri, Pseudomonas stutzeri A1501
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