1.1.99.39: D-2-hydroxyglutarate dehydrogenase

This is an abbreviated version!
For detailed information about D-2-hydroxyglutarate dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-hydroxyglutarate dehydrogenase, AtD-2HGDH, D-2-HG dehydrogenase, D-2-HGA, D-2-hydroxyglutarate dehydrogenase, D2-hydroxyglutarate dehydrogenase, D2HDH, D2HGDH

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.99 With unknown physiological acceptors

                1.1.99.39 D-2-hydroxyglutarate dehydrogenase

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Results	in table
21	AA Sequence
5	Cloned(Commentary)
5	Cofactor
57	Disease/ Diagnostics
1	Expression
11	General Information
6	kcat/KM [mM/s]
7	KM Value [mM]
3	Localization
1	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
17	Organism
1	Pathway
2	pH Optimum
7	Protein Variants
4	Purification (Commentary)
1	Reaction
11	Reference
7	Source Tissue
21	Substrates and Products (Substrate)
2	Subunits
15	Synonyms
1	Systematic Name
7	Turnover Number [1/s]

General Information

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General Information on EC 1.1.99.39 - D-2-hydroxyglutarate dehydrogenase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug target

Pseudomonas aeruginosa

Q9I6H4

the dependence of Pseudomonas aeruginosa on PaD2HGDH makes the enzyme a potential therapeutic target against Pseudomonas aeruginosa

762735

evolution

Pseudomonas aeruginosa

Q9I6H4

a phylogenetic tree analysis of D-2-hydroxyglutarate dehydrogenase from Pseudomonas aeruginosa, vanillyl alcohol oxidase, and human D-2-hydroxyglutarate dehydrogenase establishes genetic diversity among these enzymes

762735

malfunction

2 entries

metabolism

Homo sapiens

Q8N465

the enzyme elevates 2-oxoglutarate levels, influencing histone and DNA methylation, and HIF1alpha hydroxylation, and induces mitochondrial isocitrate dehydrogenase activity

741050

physiological function

6 entries

malfunction

Pseudomonas stutzeri

-

deletion mutant displays decreased growth. The defect is rescued by adding L-serine

763643

malfunction

Pseudomonas stutzeri A1501

-

deletion mutant displays decreased growth. The defect is rescued by adding L-serine

-

physiological function

Pseudomonas aeruginosa

Q9I6H4

the enzyme catalyzes a necessary step in the serine biosynthetic pathway

762735

physiological function

Homo sapiens

Q8N465

the enzyme directly reduces recombinant human electron transferring flavoprotein (ETF), thus establishing a metabolic link between the oxidation of D-2-hydroxyglutarate and the mitochondrial electron transport chain

762750

physiological function

Pseudomonas stutzeri

-

the enzyme is functionally tied to L-serine synthesis. D-2-Hydroxyglutarate-mediated coupling between D-3-phosphoglycerate dehydrogenase (SerA) and D-2-hydroxyglutarate dehydrogenase drives bacterial L-serine synthesis

763643

physiological function

Pseudomonas stutzeri

-

the enzyme plays a dual role in L-serine biosynthesis and D-malate utilization

763256

physiological function

Pseudomonas stutzeri A1501

-

the enzyme plays a dual role in L-serine biosynthesis and D-malate utilization

-

physiological function

Pseudomonas stutzeri A1501

-

the enzyme is functionally tied to L-serine synthesis. D-2-Hydroxyglutarate-mediated coupling between D-3-phosphoglycerate dehydrogenase (SerA) and D-2-hydroxyglutarate dehydrogenase drives bacterial L-serine synthesis

-