1.1.99.36: alcohol dehydrogenase (nicotinoprotein)
This is an abbreviated version!
For detailed information about alcohol dehydrogenase (nicotinoprotein), go to the full flat file.
Word Map on EC 1.1.99.36
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1.1.99.36
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nicotinoproteins
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erythropolis
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rhodococcus
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dehydrogenases
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methanolica
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formaldehyde
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amycolatopsis
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nadp
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n,n-dimethyl-4-nitrosoaniline
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dismutase
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methanol
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synthesis
- 1.1.99.36
-
nicotinoproteins
- erythropolis
-
rhodococcus
- dehydrogenases
- methanolica
- formaldehyde
- amycolatopsis
- nadp
- n,n-dimethyl-4-nitrosoaniline
- dismutase
- methanol
- synthesis
Reaction
Synonyms
4-nitroso-N, N-dimethylaniline-dependent alcohol dehydrogenase, NDMA-ADH, NDMA-dependent alcohol dehydrogenase, np-ADH
ECTree
1.1.99.36 alcohol dehydrogenase (nicotinoprotein)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 1.1.99.36 - alcohol dehydrogenase (nicotinoprotein)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-butanol + N,N-dimethyl-4-nitrosoaniline
butanaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
-
-
-
?
1-hexanol + N,N-dimethyl-4-nitrosoaniline
hexanal + 4-(hydroxylamino)-N,N-dimethylaniline
-
-
-
?
1-propanol + N,N-dimethyl-4-nitrosoaniline
propanaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
-
-
-
?
2-butanol + N,N-dimethyl-4-nitrosoaniline
butanone + 4-(hydroxylamino)-N,N-dimethylaniline
-
-
-
?
2-propanol + N,N-dimethyl-4-nitrosoaniline
acetone + 4-(hydroxylamino)-N,N-dimethylaniline
-
-
-
?
acetate + N,N-dimethyl-4-nitrosoaniline
? + 4-(hydroxylamino)-N,N-dimethylaniline
-
-
-
?
acetophenone + 1-propanol
?
-
4.3% yield, enantiomeric excess of 0.99 for (S)-product chiral secondary alcohol
3.8% yield, enantiomeric excess of 0.99 for (S)-product
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r
acetophenone + cyclohexanol
?
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2.8-3.7% yield, depending on the ratio of substrates, enantiomeric excess of 0.95-0.99 for (S)-product chiral secondary alcohol
3.8% yield, enantiomeric excess of 0.99 for (S)-product
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r
acetophenone + ethanol
?
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3.8% yield, enantiomeric excess of 0.99 for (S)-product chiral secondary alcohol
3.8% yield, enantiomeric excess of 0.99 for (S)-product
-
r
ethanol + N,N-dimethyl-4-nitrosoaniline
acetaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
methanol + N,N-dimethyl-4-nitrosoaniline
formaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
1-butanol + N,N-dimethyl-4-nitrosoaniline
butanal + 4-(hydroxylamino)-N,N-dimethylaniline
-
-
-
?
1-butanol + N,N-dimethyl-4-nitrosoaniline
butanal + 4-(hydroxylamino)-N,N-dimethylaniline
-
-
-
-
?
ethanol + N,N-dimethyl-4-nitrosoaniline
acetaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
-
-
-
?
ethanol + N,N-dimethyl-4-nitrosoaniline
acetaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
-
-
-
-
?
methanol + N,N-dimethyl-4-nitrosoaniline
formaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
-
-
-
?
methanol + N,N-dimethyl-4-nitrosoaniline
formaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
best substrate
-
-
?
methanol + N,N-dimethyl-4-nitrosoaniline
formaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
-
-
-
-
?
methanol + N,N-dimethyl-4-nitrosoaniline
formaldehyde + 4-(hydroxylamino)-N,N-dimethylaniline
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best substrate
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-
?
additional information
?
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enzyme shows formaldehyde dismutase activity producing methylformate when incubated with formaldehyde and methanol
-
-
?
additional information
?
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enzyme shows formaldehyde dismutase activity producing methylformate when incubated with formaldehyde and methanol
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-
?
additional information
?
-
-
no activity with electron acceptors NAD+, NADP+, 3-acetylpyridine adenine dinucleotide, thionicotinamide adenine dinucleotide, phenazine methosulfate, Wurster's Blue, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliurn bromide, or cytochrome c
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-
?
additional information
?
-
no activity with electron acceptors NAD+, NADP+, 3-acetylpyridine adenine dinucleotide, thionicotinamide adenine dinucleotide, phenazine methosulfate, Wurster's Blue, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliurn bromide, or cytochrome c
-
-
?
additional information
?
-
-
no activity with electron acceptors NAD+, NADP+, 3-acetylpyridine adenine dinucleotide, thionicotinamide adenine dinucleotide, phenazine methosulfate, Wurster's Blue, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliurn bromide, or cytochrome c
-
-
?
additional information
?
-
-
catalyzes the asymmetric reduction of ketones using cheap reductants, such as ethanol, with high stereoselectivity, but the reaction is too slow to obtain good yields
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-
?
