1.1.99.21: D-sorbitol dehydrogenase (acceptor)
This is an abbreviated version!
For detailed information about D-sorbitol dehydrogenase (acceptor), go to the full flat file.
Reaction
Synonyms
D-sorbitol dehydrogenase, FAD-SLDH, GoSLDH, mSLDH, PQQ-dependent D-sorbitol dehydrogenase, SDH, SLDH, sldhAB, sorbitol dehydrogenase
ECTree
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Application
Application on EC 1.1.99.21 - D-sorbitol dehydrogenase (acceptor)
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pharmacology
synthesis
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miglitol (N-hydroxyethyl-1-deoxynojirimycin), a type of hypoglycemic drug works by competitively inhibiting alpha-glucosidase activity to control postprandial blood glucose, can be used in the treatment of type II diabetes mellitus. 6-(N-hydroxyethyl)-amino-6-deoxy-alpha-L-sorbofuranose, is a key intermediate for the synthesis of miglitol, is produced from N-2-hydroxyethyl glucamine (NHEG) by biotransformation with resting cells of Gluconobacter oxydans. Balanced co-expression of both the mSLDH and the PQQ synthases is effective for the industrial production of 6-(N-hydroxyethyl)-amino-6-deoxy-L-sorbofuranose
pharmacology
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synergistic improvement of PQQ-dependent D-sorbitol dehydrogenase activity from Gluconobacter oxydans for the biosynthesis of miglitol precursor 6-(N-hydroxyethyl)-amino-6-deoxy-alpha-L-sorbofuranose. Miglitol (N-hydroxyethyl-1-deoxynojirimycin) is a pseudomonosaccharide glucosidase inhibitor in the treatment of non-insulin-dependent mellitus
pharmacology
Gluconobacter oxydans ZJB-605
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synergistic improvement of PQQ-dependent D-sorbitol dehydrogenase activity from Gluconobacter oxydans for the biosynthesis of miglitol precursor 6-(N-hydroxyethyl)-amino-6-deoxy-alpha-L-sorbofuranose. Miglitol (N-hydroxyethyl-1-deoxynojirimycin) is a pseudomonosaccharide glucosidase inhibitor in the treatment of non-insulin-dependent mellitus
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production of 6-amino-L-sorbose, which is an intermediate in the miglitol production and an intermediate for oral alpha-glucosidase-inhibitors
synthesis
the most prominent industrial method of producing L-sorbose is the biotransformation of D-sorbitol to L-sorbose in Gluconobacter species or Acetobacter species. L-sorbose is an important carbohydrate that is predominantly used as a starting material in the biosynthesis of L-ascorbic acid
synthesis
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biosynthesis of miglitol intermediate 6-(N-hydroxyethyl)-amino-6-deoxy-alpha-L-sorbofuranose by an improved D-sorbitol dehydrogenase from Gluconobacter oxydans. Miglitol (N-hydroxyethyl-1-deoxynojirimycin) is a pseudomonosaccharide alpha-glucosidase inhibitor in the treatment of non-insulin-dependent mellitus
synthesis
Gluconobacter oxydans ZJB16009
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biosynthesis of miglitol intermediate 6-(N-hydroxyethyl)-amino-6-deoxy-alpha-L-sorbofuranose by an improved D-sorbitol dehydrogenase from Gluconobacter oxydans. Miglitol (N-hydroxyethyl-1-deoxynojirimycin) is a pseudomonosaccharide alpha-glucosidase inhibitor in the treatment of non-insulin-dependent mellitus
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synthesis
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the most prominent industrial method of producing L-sorbose is the biotransformation of D-sorbitol to L-sorbose in Gluconobacter species or Acetobacter species. L-sorbose is an important carbohydrate that is predominantly used as a starting material in the biosynthesis of L-ascorbic acid
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