1.1.99.2: L-2-hydroxyglutarate dehydrogenase

This is an abbreviated version!
For detailed information about L-2-hydroxyglutarate dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-hydroxyglutarate dehydrogenase, alpha-hydroxyglutarate dehydrogenase, alpha-hydroxyglutarate dehydrogenase (NAD+ specific), alpha-hydroxyglutarate oxidoreductase, alpha-ketoglutarate reductase, dehydrogenase, 2-hydroxyglutarate, hydroxyglutaric dehydrogenase, L-2-HG dehydrogenase, L-2-HGDH, L-2-hydroxyglutarate dehydrogenase, L-2-hydroxyglutaric acid dehydrogenase, L-2HG dehydrogenase, L-2HGDH, L-alpha-hydroxyglutarate dehydrogenase, L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase, L2HGDH

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.99 With unknown physiological acceptors

                1.1.99.2 L-2-hydroxyglutarate dehydrogenase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
139	AA Sequence
3	Application
1	CAS Registry Number
1	Cloned(Commentary)
11	Cofactor
1	Crystallization (Commentary)
60	Disease/ Diagnostics
3	General Information
1	General Stability
2	Inhibitors
1	Ki Value [mM]
13	KM Value [mM]
5	Localization
1	Metals/Ions
3	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
16	Organism
4	Pathway
5	pH Optimum
4	pH Range
45	Protein Variants
4	Purification (Commentary)
1	Reaction
5	Reaction Type
16	Reference
16	Source Tissue
3	Specific Activity [micromol/min/mg]
31	Substrates and Products (Substrate)
2	Subunits
22	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 1.1.99.2 - L-2-hydroxyglutarate dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(S)-2-hydroxyglutarate + acceptor

2-oxoglutarate + reduced acceptor

3 entries

(S)-2-hydroxyglutarate + FAD

2-oxoglutarate + FADH2

Rattus norvegicus

-

enzyme deficiency might be the cause of L-2-hydroxyglutaric aciduria

657168

-

-

?

(S)-2-hydroxyglutarate + NAD+

2-oxoglutarate + NADH + H+

Homo sapiens

-

-

754339

-

-

?

L-2-hydroxyglutarate + FAD

2-oxoglutarate + FADH2

Homo sapiens

-

-

752906

-

-

ir

L-2-hydroxyglutarate + NAD+

2-oxoglutarate + NADH + H+

Homo sapiens

-

-

752906

-

-

r

additional information

?

-

2 entries

(S)-2-hydroxyglutarate + acceptor

2-oxoglutarate + reduced acceptor

Homo sapiens

-

-

712128

-

-

?

(S)-2-hydroxyglutarate + acceptor

2-oxoglutarate + reduced acceptor

Homo sapiens

Q9H9P8

enzyme deficiency might be the cause of L-2-hydroxyglutaric aciduria

657168

-

-

?

(S)-2-hydroxyglutarate + acceptor

2-oxoglutarate + reduced acceptor

Rattus norvegicus

-

enzyme deficiency might be the cause of L-2-hydroxyglutaric aciduria

654542

-

-

?

additional information

?

-

Alcaligenes sp.

-

high levels of the enzyme is produced at the late stage of cultivation in the presence of citrate and with limited aeration

389902

-

-

?

additional information

?

-

Homo sapiens

-

mutations (K81E, E176D, DELTA-exon9) found in patients with L-2-hydroxyglutaric aciduria supress L-2-hydroxyglutarate dehydrogenase activity. L-2-hydroxyglutartic aciduria is due to a deficiency in L-2-hydroxyglutarate dehydrogenase

678483

-

-

?