1.1.99.2: L-2-hydroxyglutarate dehydrogenase

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For detailed information about L-2-hydroxyglutarate dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-hydroxyglutarate dehydrogenase, alpha-hydroxyglutarate dehydrogenase, alpha-hydroxyglutarate dehydrogenase (NAD+ specific), alpha-hydroxyglutarate oxidoreductase, alpha-ketoglutarate reductase, dehydrogenase, 2-hydroxyglutarate, hydroxyglutaric dehydrogenase, L-2-HG dehydrogenase, L-2-HGDH, L-2-hydroxyglutarate dehydrogenase, L-2-hydroxyglutaric acid dehydrogenase, L-2HG dehydrogenase, L-2HGDH, L-alpha-hydroxyglutarate dehydrogenase, L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase, L2HGDH

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.99 With unknown physiological acceptors

                1.1.99.2 L-2-hydroxyglutarate dehydrogenase

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Results	in table
139	AA Sequence
3	Application
1	CAS Registry Number
1	Cloned(Commentary)
11	Cofactor
1	Crystallization (Commentary)
60	Disease/ Diagnostics
3	General Information
1	General Stability
2	Inhibitors
1	Ki Value [mM]
13	KM Value [mM]
5	Localization
1	Metals/Ions
3	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
16	Organism
4	Pathway
5	pH Optimum
4	pH Range
45	Protein Variants
4	Purification (Commentary)
1	Reaction
5	Reaction Type
16	Reference
16	Source Tissue
3	Specific Activity [micromol/min/mg]
31	Substrates and Products (Substrate)
2	Subunits
22	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

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Cloned on EC 1.1.99.2 - L-2-hydroxyglutarate dehydrogenase

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

transfection of HEK cells with cDNA encoding the product of the human gene leads to more than 15fold increase in L-2-hydroxyglutarate dehydrogenase activity

Homo sapiens

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