1.1.98.3: decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase
This is an abbreviated version!
For detailed information about decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.98.3
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1.1.98.3
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tuberculosis
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mycobacterium
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antitubercular
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benzothiazinones
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antimycobacterial
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antituberculosis
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pbtz169
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arabinans
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arabinogalactan
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anti-tb
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corynebacterineae
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drug-susceptible
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xdr-tb
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1,2,3-triazole
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tca1
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dinitrobenzamides
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nitroso
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analysis
- 1.1.98.3
- tuberculosis
- mycobacterium
-
antitubercular
-
benzothiazinones
-
antimycobacterial
-
antituberculosis
- pbtz169
- arabinans
- arabinogalactan
-
anti-tb
- corynebacterineae
-
drug-susceptible
-
xdr-tb
-
1,2,3-triazole
- tca1
-
dinitrobenzamides
-
nitroso
- analysis
Reaction
Synonyms
decaprenylphospho-beta-D-ribofuranose 2-oxidase, decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase, decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase, decaprenylphosphoryl-beta-D-ribose 2'-epimerase, decaprenylphosphoryl-beta-D-ribose 2'-oxidase, decaprenylphosphoryl-beta-D-ribose 2-epimerase, decaprenylphosphoryl-beta-D-ribose oxidase, decaprenylphosphoryl-beta-D-ribose-2'-epimerase, decaprenylphosphoryl-D-ribose oxidase, DprE1, DprE2, MSMEG_6382, Rv3790
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General Information
General Information on EC 1.1.98.3 - decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase
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physiological function
construction of a conditional gene knockout strain targeting the gene encoding subunit dprE1 of decaprenylphosphoribose 2' epimerase. The gene is essential for viability, results suggests that decaprenylphosphoryl arabinose synthesis is essential in mycobacteria, indicate a lack of redundancy in decaprenylphosphoryl arabinose synthesis and suggest that no alternative arabinose donors for cell wall biosynthesis exist
physiological function
decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase is constituted of DprE1 and DprE2 that together catalyze the epimerization of decaprenylphosphoryl-beta-D-ribofuranose to decaprenylphosphoryl-beta-D-arabinofuranose
physiological function
decaprenylphosphoryl-D-arabinofuranose is synthesized by the following sequence of events: 5-phosphoribose 1-diphosphate is transferred to a decaprenyl-phosphate molecule to form decaprenylphosphoryl-beta-D-5-phosphoribose. Decaprenylphosphoryl-beta-D-5-phosphoribose is dephosphorylated to form decaprenylphosphoryl-beta-D-ribose. The hydroxyl group at the 2 position of the ribose is oxidized and is likely to form decaprenylphosphoryl-2-keto-beta-D-erythro-pentofuranose. Decaprenylphosphoryl-2-keto-beta-D-erythro-pentofuranose is reduced to form decaprenylphosphoryl-beta-D-arabinofuranose. Thus, the epimerization of the ribosyl to an arabinosyl residue occurs at the lipid-linked level
physiological function
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decaprenylphosphoryl-D-arabinofuranose is synthesized by the following sequence of events: 5-phosphoribose 1-diphosphate is transferred to a decaprenyl-phosphate molecule to form decaprenylphosphoryl-beta-D-5-phosphoribose. Decaprenylphosphoryl-beta-D-5-phosphoribose is dephosphorylated to form decaprenylphosphoryl-beta-D-ribose. The hydroxyl group at the 2 position of the ribose is oxidized and is likely to form decaprenylphosphoryl-2-keto-beta-D-erythro-pentofuranose. Decaprenylphosphoryl-2-keto-beta-D-erythro-pentofuranose is reduced to form decaprenylphosphoryl-beta-D-arabinofuranose. Thus, the epimerization of the ribosyl to an arabinosyl residue occurs at the lipid-linked level
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