1.1.98.3: decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase
This is an abbreviated version!
For detailed information about decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.98.3
-
1.1.98.3
-
tuberculosis
-
mycobacterium
-
antitubercular
-
benzothiazinones
-
antimycobacterial
-
antituberculosis
-
pbtz169
-
arabinans
-
arabinogalactan
-
anti-tb
-
corynebacterineae
-
drug-susceptible
-
xdr-tb
-
1,2,3-triazole
-
tca1
-
dinitrobenzamides
-
nitroso
-
analysis
- 1.1.98.3
- tuberculosis
- mycobacterium
-
antitubercular
-
benzothiazinones
-
antimycobacterial
-
antituberculosis
- pbtz169
- arabinans
- arabinogalactan
-
anti-tb
- corynebacterineae
-
drug-susceptible
-
xdr-tb
-
1,2,3-triazole
- tca1
-
dinitrobenzamides
-
nitroso
- analysis
Reaction
Synonyms
decaprenylphospho-beta-D-ribofuranose 2-oxidase, decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase, decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase, decaprenylphosphoryl-beta-D-ribose 2'-epimerase, decaprenylphosphoryl-beta-D-ribose 2'-oxidase, decaprenylphosphoryl-beta-D-ribose 2-epimerase, decaprenylphosphoryl-beta-D-ribose oxidase, decaprenylphosphoryl-beta-D-ribose-2'-epimerase, decaprenylphosphoryl-D-ribose oxidase, DprE1, DprE2, MSMEG_6382, Rv3790
ECTree
Advanced search results
Crystallization
Crystallization on EC 1.1.98.3 - decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
crystals are grown from a mixture of ethyl acetate/heptane by slow evaporation
different crystal forms of ligand-free enzyme reveal considerable levels of structural flexibility of two surface loops that seem to govern accessibility of the active site. Structures of complexes with the benzothiazinone-derived nitroso derivative 3-nitroso-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide reveal that inhibitor binding includes a covalent link to conserved Cys387, and reveal a trifluoromethyl group as a second key determinant of interaction with the enzyme. A noncovalent complex is formed between the enzyme and 3-nitro-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide, which is structurally identical to 3-nitroso-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide except for an inert nitro group replacing the reactive nitroso group. Binding of benzothiazinone-class inhibitors to the enzyme is not strictly dependent on formation of the covalent link to Cys387
sitting drop vapor diffusion method, using 15-20% (v/v) isopropanol, 0.2 M sodium citrate pH 6.8, and 0.5% (w/v) N,N-dimethyldodecylamine-N-oxide