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1.1.98.2: glucose-6-phosphate dehydrogenase (coenzyme-F420)

This is an abbreviated version!
For detailed information about glucose-6-phosphate dehydrogenase (coenzyme-F420), go to the full flat file.

Word Map on EC 1.1.98.2

Reaction

D-glucose 6-phosphate
+
oxidized coenzyme F420
=
6-phospho-D-glucono-1,5-lactone
+
reduced coenzyme F420

Synonyms

Rv0407, coenzyme F420-dependent glucose-6-phosphate dehydrogenase, EC 1.1.99.34, F420-dependent glucose-6-phosphate dehydrogenase, FGD, FGD1, glucose-6-phosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.98 With other, known, physiological acceptors
                1.1.98.2 glucose-6-phosphate dehydrogenase (coenzyme-F420)

Application

Application on EC 1.1.98.2 - glucose-6-phosphate dehydrogenase (coenzyme-F420)

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
PA-824 is a compound for the treatment of tuberculosis (undergoing human trials). PA-824 is a prodrug of the nitroimidazole class, requiring bioreductive activation of an aromatic nitro group to exert an antitubercular effect. Resistance to PA-824 (a nitroimidazo-oxazine) and CGI-17341 (a nitroimidazo-oxazole) is most commonly mediated by loss of a specific glucose-6-phosphate dehydrogenase or its deazaflavin cofactor F420, which together provide electrons for the reductive activation of this class of molecules. Although glucose-6-phosphate dehydrogenase and F420 are necessary for sensitivity to these compounds, they are not sufficient and require additional accessory proteins that directly interact with the nitroimidazole. The sensitivity of Mtb to PA-824 and related compounds is mediated by a protein that is highly specific for subtle structural variations in these bicyclic nitroimidazoles