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1.1.5.5: alcohol dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about alcohol dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.1.5.5

Reaction

ethanol
+
ubiquinone
=
acetaldehyde
 +
ubiquinol

Synonyms

ADD, ADH, ADH I, ADH IIB, ADH IIG, ADH-1, ADH-GS, ADH-IIB, ADH-IIG, AdhA, ADHI, ADHIIB, ADHIIG, alcohol dehydrogenase, bacterial methanol dehydrogenase, BDH, BOH, calcium-containing quinoprotein methanol dehydrogenase, EC 1.1.99.8, exaA, ExaA2, ExaA3, formaldehyde-oxidizing enzyme, GLDH, glycerol dehydrogenase, LEMA_P002680.1, lupanine hydroxylase (PQQ/heme c), MDH, MDH-PQQ, MEDH, MEDH-PD, membrane quinohaemoprotein alcohol dehydrogenase, membrane-bound alcohol dehydrogenase, methanol dehydrogenase, More, NAD+-independent, PQQ-containing alcohol dehydrogenase, PedE, PedH, PEGDH, polyethyleneglycol dehydrogenase, polypropylene glycol dehydrogenase, polypropyleneglycol dehydrogenase, polyvinylalcohol dehydrogenase, PPG-DH, PPGDH, PQQ ADH, PQQ alcohol dehydrogenase, PQQ dependent alcohol dehydrogenase, PQQ methanol dehydrogenase, PQQ-ADH, PQQ-alcohol dehydrogenase, PQQ-containing methanol dehydrogenase, PQQ-dependent ADH, PQQ-dependent alcohol dehydrogenase, PQQ-dependent alcohol oxidase, PQQ-dependent ethanol dehydrogenase, PQQ-dependent quinoprotein ethanol dehydrogenase, PQQ-linked alcohol dehydrogenase, PQQ–alcohol dehydrogenase, PVADH, pyrrolo-quinoline quinone-dependent alcohol dehydrogenase, pyrroloquinoline quinone (PQQ)-dependent alcohol dehydrogenase, pyrroloquinoline quinone -dependent quinoprotein ethanol dehydrogenase, pyrroloquinoline quinone dependent ADH, pyrroloquinoline quinone dependent alcohol dehydrogenase, pyrroloquinoline quinone methanol dehydrogenase, pyrroloquinoline quinone-dependent alcohol dehydrogenase, pyrroloquinoline quinone-dependent quinoprotein alcohol dehydrogenase, pyrroloquinoline quinone-dependent quinoprotein methanol dehydrogenase, pyrroloquinoline quinone–alcohol dehydrogenase, pyrroquinoline quinone-dependent alcohol dehydrogenase, Q-bound ADH, QADH, QEDH, QH-ADH, quinocytochrome alcohol dehydrogenase GS, quinocytochrome alcohol dehydrogenase IIB, quinohaemoprotein alcohol dehydrogenase, quinohemoprotein (type II) alcohol dehydrogenase, quinohemoprotein alcohol dehydrogenase, quinohemoprotein dehydrogenase, quinohemoprotein ethanol dehydrogenase, quinohemoprotein-cytochrome c complex alcohol dehydrogenase, quinone dependent alcohol dehydrogenase, quinone-dependent alcohol dehydrogenase, quinoprotein ADH, quinoprotein alcohol dehydrogenase, quinoprotein dehydrogenase, quinoprotein ethanol dehydrogenase, quinoprotein MDG, quinoprotein methanol dehydrogenase, tetrahydrofurfuryl alcohol dehydrogenase, THFA-DH, THFADH, type I ADH (PQQ), type II ADH, type II ADH (PQQ/heme c), type II quinohemoprotein alcohol dehydrogenase, type III ADH (PQQ/heme c /3 hemes c), vanillyl alcohol dehydrogenase, YogA

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                1.1.5.5 alcohol dehydrogenase (quinone)

Substrates Products

Substrates Products on EC 1.1.5.5 - alcohol dehydrogenase (quinone)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,2-propanediol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
9.1% activity compared to 1-propanol
-
-
r
1,3-butandiol + ubiquinone
? + ubiquinol
show the reaction diagram
-
very low activity, 0.94% of the activity with ethanol
-
-
?
1,3-propandiol + ubiquinone
? + ubiquinol
show the reaction diagram
-
15% of the activity with ethanol
-
-
?
1,3-propanediol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
12.2% activity compared to 1-propanol
-
-
r
1,4-butanediol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
16.2% activity compared to 1-propanol
-
-
r
1-butanol + 2,6-dichlorophenolindophenol
butyraldehyde + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
1-butanol + ubiquinone
butanal + ubiquinol
show the reaction diagram
-
88% of the activity with ethanol
-
-
?
1-heptanol + 2,6-dichlorophenolindophenol
heptanal + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
1-hexanol + 2,6-dichlorophenolindophenol
hexanal + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
1-hexanol + ubiquinone
hexanal + ubiquinol
show the reaction diagram
-
93% of the activity with ethanol
-
-
?
1-octanol + ubiquinone
octanal + ubiquinol
show the reaction diagram
-
66% of the activity with ethanol
-
-
?
1-pentanol + 2,6-dichlorophenolindophenol
pentanaldehyde + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
85.5% activity compared to 1-propanol
-
-
r
1-pentanol + ubiquinone
pentanal + ubiquinol
show the reaction diagram
-
97% of the activity with ethanol
-
-
?
1-propanol + 2,6-dichlorophenolindophenol
propionaldehyde + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
1-propanol + phenazine methosulfate
propionaldehyde + reduced phenazine methosulfate
show the reaction diagram
-
100% activity
-
-
r
1-propanol + ubiquinone
propanal + ubiquinol
show the reaction diagram
-
90% of the activity with ethanol
-
-
?
2,3-butanediol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
4.1% activity compared to 1-propanol
-
-
r
2-(S)-butanol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
43.3% activity compared to 1-propanol
-
-
r
2-butanol + ubiquinone
2-butanone + ubiquinol
show the reaction diagram
-
64% of the activity with ethanol
-
-
?
2-propanol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
31.9% activity compared to 1-propanol
-
-
r
2-propanol + ubiquinone
acetone + ubiquinol
show the reaction diagram
-
51% of the activity with ethanol
-
-
?
3-methyl-1-butanol + ubiquinone
3-methyl-1-butanal + ubiquinol
show the reaction diagram
-
48% of the activity with ethanol
-
-
?
5-(hydroxymethyl)furfural + phenazine methosulfate
? + reduced phenazine methosulfate
show the reaction diagram
-
-
-
?
5-(hydroxymethyl)furoic acid + phenazine methosulfate
? + reduced phenazine methosulfate
show the reaction diagram
wild-type enzyme shows no activity, mutant enzymes F412V/W561A, F412I/W561Q and F412I/W561S are active
-
-
?
5-formylfurfural + phenazine methosulfate
? + reduced phenazine methosulfate
show the reaction diagram
-
-
-
?
acetaldehyde + 2,6-dichlorophenolindophenol
?
show the reaction diagram
-
42% activity compared to n-butanol. The enzyme also oxidizes aldehydes, however the affinity for alcohols is at least twice as high
-
-
?
acetaldehyde + ferricyanide
?
show the reaction diagram
-
13% activity compared to n-butanol. The enzyme also oxidizes aldehydes, however the affinity for alcohols is at least twice as high
-
-
?
acetaldehyde + reduced 2,6-dichlorophenolindophenol
ethanol + 2,6-dichlorophenolindophenol
show the reaction diagram
-
-
-
-
r
acetaldehyde + reduced phenazine methosulfate
ethanol + phenazine methosulfate
show the reaction diagram
-
55.6% activity compared to 1-propanol
-
-
r
acetaldehyde + ubiquinol
ethanol + ubiquinone
show the reaction diagram
allyl alcohol + ferricyanide
acrolein + ferricyanide
show the reaction diagram
-
the best substrate
-
-
?
allylic alcohol + 2,6-dichlorophenolindophenol
?
show the reaction diagram
-
91% activity compared to n-butanol
-
-
?
allylic alcohol + ferricyanide
?
show the reaction diagram
-
96% activity compared to n-butanol
-
-
?
benzyl alcohol + 2,6-dichlorophenolindophenol
benzaldehyde + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
butyraldehyde + reduced 2,6-dichlorophenolindophenol
1-butanol + 2,6-dichlorophenolindophenol
show the reaction diagram
-
32.1% activity compared to 1-propanol
-
-
r
citral + ubiquinol
? + ubiquinone
show the reaction diagram
-
39% of the activity with ethanol
-
-
?
citronellal + ubiquinol
citronellol + ubiquinone
show the reaction diagram
-
45% of the activity with ethanol
-
-
?
citronellol + ubiquinone
citronellal + ubiquinol
show the reaction diagram
-
74% of the activity with ethanol
-
-
?
cyclohexanol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
5.5% activity compared to 1-propanol
-
-
r
D-galactose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
85% activity compared to D-glucose
-
-
?
D-glucose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
D-mannose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
77% activity compared to D-glucose
-
-
?
D-sorbitol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
9.0% activity compared to D-glucose
-
-
?
D-xylose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
130% activity compared to D-glucose
-
-
?
ethanol + 2,6-dichlorophenol indophenol
acetaldehyde + reduced 2,6-dichlorophenol indophenol
show the reaction diagram
ethanol + 2,6-dichlorophenolindophenol
acetaldehyde + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
ethanol + acceptor
acetaldehyde + reduced acceptor
show the reaction diagram
ethanol + ferricyanide
acetaldehyde + ferrocyanide
show the reaction diagram
ethanol + phenazine methosulfate
acetaldehyde + reduced phenazine methosulfate
show the reaction diagram
ethanol + phenazine methosulfate + 2,6-dichlorophenolindophenol
?
show the reaction diagram
ethanol + pyrroloquinoline quinone
acetaldehyde + pyrroloquinoline quinol
show the reaction diagram
ethanol + ubiquinone
acetaldehyde + ubiquinol
show the reaction diagram
ethanol + ubiquinone-1
acetaldehyde + ubiquinol-1
show the reaction diagram
ethyleneglycol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
109% activity compared to D-glucose
-
-
?
formaldehyde + 2,6-dichlorophenolindophenol
?
show the reaction diagram
-
38% activity compared to n-butanol. The enzyme also oxidizes aldehydes, however the affinity for alcohols is at least twice as high
-
-
?
formaldehyde + ferricyanide
?
show the reaction diagram
-
34% activity compared to n-butanol. The enzyme also oxidizes aldehydes, however the affinity for alcohols is at least twice as high
-
-
?
geraniol + ubiquinone
geranial + ubiquinol
show the reaction diagram
-
37% of the activity with ethanol
-
-
?
glutaraldehyde + 2,6-dichlorophenolindophenol
?
show the reaction diagram
-
18% activity compared to n-butanol. The enzyme also oxidizes aldehydes, however the affinity for alcohols is at least twice as high
-
-
?
glutaraldehyde + ferricyanide
?
show the reaction diagram
iso-propanol + ferricyanide
propan-2-one + ferrocyanide
show the reaction diagram
-
about 10% of the activity with n-butanol
-
-
?
isopropanol + 2,6-dichlorophenolindophenol
propionaldehyde + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
121% activity compared to D-glucose
-
-
?
isopropanol + ferricyanide
propan-2-one + ferrocyanide
show the reaction diagram
-
18% of the activity with allyl alcohol
-
-
?
L-sorbose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
0.6% activity compared to D-glucose
-
-
?
maltotetraose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
24% activity compared to D-glucose
-
-
?
maltotriose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
31% activity compared to D-glucose
-
-
?
methanol + 2,6-dichlorophenolindophenol
formaldehyde + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
methanol + ferricyanide
formaldehyde + ferrocyanide
show the reaction diagram
-
9% of the activity with allyl alcohol
-
-
?
methanol + phenazine methosulfate
formaldehyde + reduced phenazine methosulfate
show the reaction diagram
-
6.3% activity compared to 1-propanol
-
-
r
methyl-alpha-D-glucopyranoside + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
5% activity compared to D-glucose
-
-
?
n-butanol + 2,6-dichlorophenolindophenol
butyraldehyde + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
n-butanol + 2,6-dichlorophenolindophenol
n-butanal + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
100% activity
-
-
?
n-butanol + ferricyanide
butyraldehyde + ferrocyanide
show the reaction diagram
-
98% of the activity with allyl alcohol
-
-
?
n-butanol + ferricyanide
n-butanal + ferrocyanide
show the reaction diagram
-
-
-
-
?
n-pentanol + ferricyanide
n-pentanal + ferrocyanide
show the reaction diagram
-
about 45% of the activity with n-butanol
-
-
?
n-propanol + 2,6-dichlorophenolindophenol
propionaldehyde + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
n-propanol + ferricyanide
n-propanal + ferrocyanide
show the reaction diagram
n-propanol + ferricyanide
propionaldehyde + ferrocyanide
show the reaction diagram
-
90% of the activity with allyl alcohol
-
-
?
n-propanol + oxidized 2,6-dichlorophenolindophenol
n-propanal + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
96% activity compared to n-butanol
-
-
?
propan-1,2,3-triol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
25% activity compared to D-glucose
-
-
?
propionaldehyde + 2,6-dichlorophenolindophenol
?
show the reaction diagram
-
33% activity compared to n-butanol. The enzyme also oxidizes aldehydes, however the affinity for alcohols is at least twice as high
-
-
?
propionaldehyde + ferricyanide
?
show the reaction diagram
-
24% activity compared to n-butanol. The enzyme also oxidizes aldehydes, however the affinity for alcohols is at least twice as high
-
-
?
propionaldehyde + reduced 2,6-dichlorophenolindophenol
1-propanol + 2,6-dichlorophenolindophenol
show the reaction diagram
-
-
-
-
r
propionaldehyde + reduced phenazine methosulfate
1-propanol + phenazine methosulfate
show the reaction diagram
-
54.5% activity compared to 1-propanol
-
-
r
rac-1,2-propanediol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
128% activity compared to D-glucose
-
-
?
rac-2-methyl-2,4-pentanediol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
164% activity compared to D-glucose
-
-
?
xylitol + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
20% activity compared to D-glucose
-
-
?
additional information
?
-