1.1.5.4: malate dehydrogenase (quinone)
This is an abbreviated version!
For detailed information about malate dehydrogenase (quinone), go to the full flat file.
Word Map on EC 1.1.5.4
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1.1.5.4
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oxaloacetate
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glutamicum
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phospholipid-requiring
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pyrroloquinoline
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lipid-depleted
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1.1.1.37
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biotechnology
- 1.1.5.4
- oxaloacetate
- glutamicum
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phospholipid-requiring
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pyrroloquinoline
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lipid-depleted
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1.1.1.37
- biotechnology
Reaction
Synonyms
EC 1.1.3.3, EC 1.1.99.16, FAD-dependent malate dehydrogenase, L-malate-quinone oxidoreductase, L-malate:quinone oxidoreductase, malate dehydrogenase, malate dehydrogenase (acceptor), malate-quinone oxidoreductase, malate-vitamin K reductase, malate: quinone oxidoreductase, malate:quinine oxidoreductase, malate:quinone oxidoreductase, malate:quinone reductase, menaquinone reductase, Mqo, MqoB, MQR, PfMQO
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General Information on EC 1.1.5.4 - malate dehydrogenase (quinone)
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
drug target
metabolism
the enzyme is involved in three pathways (mitochondrial electron transport chain, the tricarboxylic acid cycle and the fumarate cycle)
physiological function
additional information
drug target
the enzyme is a potential antimalarial drug target against the apicomplexan parasite Plasmodium falciparum, because the enzyme is absent in humans. Ferulenol inhibits parasite growth and shows strong synergism in combination with atovaquone, an anti-malarial and bc1 complex inhibitor
physiological function
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the enzyme is a component of the electron transfer chain in Pseudomonas pseudoalcaligenes CECT5344 cells, overview
physiological function
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the enzyme is involved in cyanide degradation in association with the cyanide-insensitive electron-transfer chain
physiological function
the enzyme is essential for parasite survival, at least, in the intra-erythrocytic asexual stage
physiological function
the enzyme is involved in the pathways of mitochondrial electron transport chain, tricarboxylic acid cycle, and fumarate cycle. The enzyme is essential for the survival of Plasmodium falciparum in asexual stage
physiological function
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the enzyme is required for development of experimental cerebral malaria of asexual-blood-stage Plasmodium parasites
physiological function
Pseudomonas oleovorans CECT 5344
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the enzyme is a component of the electron transfer chain in Pseudomonas pseudoalcaligenes CECT5344 cells, overview
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physiological function
Pseudomonas oleovorans CECT 5344
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the enzyme is involved in cyanide degradation in association with the cyanide-insensitive electron-transfer chain
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additional information
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because of the differences in the redox potentials of NAD+ and quinones, the MQO-catalyzed reaction progresses spontaneously compared to the MDH-catalyzed reaction, EC 1.1.1.37
additional information
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oxaloacetate reacts chemically inside the cyanide-insensitive cells to produce a cyanohydrin (2-hydroxynitrile), which is further converted to ammonium. The nitrile is transiently accumulated in cyanide-containing media
additional information
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because of the differences in the redox potentials of NAD+ and quinones, the MQO-catalyzed reaction progresses spontaneously compared to the MDH-catalyzed reaction, EC 1.1.1.37
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additional information
Pseudomonas oleovorans CECT 5344
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oxaloacetate reacts chemically inside the cyanide-insensitive cells to produce a cyanohydrin (2-hydroxynitrile), which is further converted to ammonium. The nitrile is transiently accumulated in cyanide-containing media
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