1.1.3.45: aclacinomycin-N oxidase
This is an abbreviated version!
For detailed information about aclacinomycin-N oxidase, go to the full flat file.
Word Map on EC 1.1.3.45
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1.1.3.45
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sirtuins
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deacetylation
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nad+-dependent
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nicotinamide
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hyperacetylation
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mnsod
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caloric
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sirt3-dependent
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longevity
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sirt3-mediated
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sirts
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sirt1-7
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foxo3a
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acetylome
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honokiol
- 1.1.3.45
-
sirtuins
-
deacetylation
-
nad+-dependent
- nicotinamide
-
hyperacetylation
- mnsod
-
caloric
-
sirt3-dependent
-
longevity
-
sirt3-mediated
-
sirts
-
sirt1-7
-
foxo3a
-
acetylome
- honokiol
Reaction
Synonyms
aclacinomycin oxidoreductase, AknOx, dnrW
ECTree
1.1.3.45 aclacinomycin-N oxidaseAdvanced search results
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results (Engineering
Engineering on EC 1.1.3.45 - aclacinomycin-N oxidase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
E374A
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80-100% of activity compared to wild-type enzyme, oxidation of aclacinomycin N
E374Q
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80-100% of activity compared to wild-type enzyme, oxidation of aclacinomycin N
H271A
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activity is identical to wild-type activity, oxidation of aclacinomycin N
S376A
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80-100% of activity compared to wild-type enzyme, oxidation of aclacinomycin N
Y144F
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5% of activity compared to wild-type enzyme, oxidation of aclacinomycin N
Y378F
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activity is identical to wild-type activity, oxidation of aclacinomycin N
Y378F/Y450F
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4% of activity compared to wild-type enzyme, oxidation of aclacinomycin N
Y378F/Y450F/Y144F
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inactive mutant enzyme, oxidation of aclacinomycin N
Y450F
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1-2% of activity compared to wild-type enzyme, oxidation of aclacinomycin N
