1.1.3.38: vanillyl-alcohol oxidase
This is an abbreviated version!
For detailed information about vanillyl-alcohol oxidase, go to the full flat file.
Word Map on EC 1.1.3.38
-
1.1.3.38
-
opacification
-
simplicissimum
-
ostium
-
veratryl
-
flavinylation
-
vertebrobasilar
-
aphakia
-
p-quinone
-
logmar
-
argan
-
4-ethylphenol
-
4-alkylphenols
-
synthesis
-
analysis
- 1.1.3.38
-
opacification
- simplicissimum
-
ostium
-
veratryl
-
flavinylation
-
vertebrobasilar
- aphakia
- p-quinone
-
logmar
-
argan
- 4-ethylphenol
- 4-alkylphenols
- synthesis
- analysis
Reaction
Synonyms
4-allylphenol oxidase, 4-hydroxy-2-methoxybenzyl alcohol oxidase, Aryl-alcohol oxidase, EUGO, HMFO, Oxidase, vanillyl alcohol, RHA1_ro03282, vanillyl-alcohol oxidase, VAO, VAOA
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Reference on EC 1.1.3.38 - vanillyl-alcohol oxidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Van der Heuvel, R.H.H.; Fraaije, M.W.; Laane, C.; van Berkel, W.J.H.
Regio- and stereospecific conversion of 4-alkylphenols by the covalent flavoprotein vanillyl-alcohol oxidase
J. Bacteriol.
180
5646-5651
1998
Penicillium simplicissimum
Fraaije, M.W.; Veeger, C.; van Berkel, W.J.H.
Substrate specificity of flavin-dependent vanillyl-alcohol oxidase from Penicillium simplicissimum. Evidence for the production of 4-hydroxycinnamyl alcohols from 4-allylphenols
Eur. J. Biochem.
234
271-277
1995
Penicillium simplicissimum
De Jong, E.; van Berkel, W.J.H.; van der Zwan, R.P.; de Bont, J.A.M.
Purification and characterization of vanillyl-alcohol oxidase from Penicillium simplicissimum. A novel aromatic alcohol oxidase containing covalently bound FAD
Eur. J. Biochem.
208
651-657
1992
Penicillium simplicissimum
Fraaije, M.W.; Sjollema, K.A.; Veenhuis, M.; van Berkel, W.J.H.
Subcellular localization of vanillyl-alcohol oxidase in Penicillium simplicissimum
FEBS Lett.
422
65-68
1998
Penicillium simplicissimum
Fraaije, M.W.; Mattevi, A.; van Berkel, W.J.H.
Mercuration of vanillyl-alcohol oxidase from Penicillium simplicissimum generates inactive dimers
FEBS Lett.
402
33-35
1997
Penicillium simplicissimum
Fraaije, M.W.; van Berkel, W.J.H.
Catalytic mechanism of the oxidative demethylation of 4-(methoxymethyl)phenol by vanillyl-alcohol oxidase. Evidence for formation of a p-quinone methide intermediate
J. Biol. Chem.
272
18111-18116
1997
Penicillium simplicissimum
Fraaije, M.W.; van der Heuvel, R.H.H.; Roelofs, J.C.A.A.; van Berkel, W.J.H.
Kinetic mechanism of vanillyl-alcohol oxidase with short-chain 4-alkylphenols
Eur. J. Biochem.
253
712-719
1998
Penicillium simplicissimum
Drijfhout, F.P.; Fraaije, M.W.; Jongejan, H.; van Berkel, W.J.H.; Franssen, M.C.R.
Enantioselective hydroxylation of 4-alkylphenols by vanillyl alcohol oxidase
Biotechnol. Bioeng.
59
171-177
1998
Penicillium simplicissimum
Mattevi, A.; Fraaije, M.W.; Mozzarelli, A.; Olivi, L.; Coda, A.; van Berkel, W.J.H.
Crystal structures and inhibitor binding in the octameric flavoenzyme vanillyl-alcohol oxidase: the shape of the active-site cavity controls substrate specificity
Structure
5
907-920
1997
Penicillium simplicissimum
Benen, J.A.E.; Sanchez-Torres, P.; Wagemaker, M.J.; Fraaije, M.W.; van Berkel, W.J.; Visser, J.
Molecular cloning, sequencing, and heterologous expression of the vaoA gene from Penicillium simplicissimum CBS 170.90 encoding vanillyl-alcohol oxidase
J. Biol. Chem.
273
7865-7872
1998
Penicillium simplicissimum (P56216), Penicillium simplicissimum, Penicillium simplicissimum CBS170.90 (P56216), Penicillium simplicissimum CBS170.90
Mattevi, A.; Fraaije, M.W.; Coda, A.; van Berkel, W.J.
Crystallization and preliminary X-ray analysis of the flavoenzyme vanilly-alcohol oxidase from Penicillium simplicissimum
Proteins
27
601-603
1997
Penicillium simplicissimum
van den Heuvel, R.H.H.; Laane, C.; van Berkel, W.J.H.
Exploring the biocatalytic potential of vanillyl-alcohol oxidase by site-directed mutagenesis
Adv. Synth. Catal.
343
515-520
2001
Penicillium simplicissimum
-
van den Heuvel, R.H.; Fraaije, M.W.; van Berkel, W.J.
Direction of the reactivity of vanillyl-alcohol oxidase with 4-alkylphenols
FEBS Lett.
481
109-112
2000
Penicillium simplicissimum
van den Heuvel, R.H.; Partridge, J.; Laane, C.; Halling, P.J.; van Berkel, W.J.
Tuning of the product spectrum of vanillyl-alcohol oxidase by medium engineering
FEBS Lett.
503
213-216
2001
Penicillium simplicissimum
van den Heuvel, R.H.; Fraaije, M.W.; Laane, C.; van Berkel, W.J.
Enzymatic synthesis of vanillin
J. Agric. Food Chem.
49
2954-2958
2001
Penicillium simplicissimum
Fraaije, M.W.; van den Heuvel, R.H.; van Berkel, W.J.; Mattevi, A.
Covalent flavinylation is essential for efficient redox catalysis in vanillyl-alcohol oxidase
J. Biol. Chem.
274
35514-35520
1999
Penicillium simplicissimum (P56216)
van den Heuvel, R.H.; Fraaije, M.W.; Mattevi, A.; van Berkel, W.J.
Asp-170 is crucial for the redox properties of vanillyl-alcohol oxidase
J. Biol. Chem.
275
14799-14808
2000
Penicillium simplicissimum
Fraaije, M.W.; van den Heuvel, R.H.; van Berkel, W.J.; Mattevi, A.
Structural analysis of flavinylation in vanillyl-alcohol oxidase
J. Biol. Chem.
275
38654-38658
2000
Penicillium simplicissimum (P56216)
Tahallah, N.; van den Heuvel, R.H.; van den Berg, W.A.; Maier, C.S.; van Berkel, W.J.; Heck, A.J.
Cofactor-dependent assembly of the flavoenzyme vanillyl-alcohol oxidase
J. Biol. Chem.
277
36425-36432
2002
Penicillium simplicissimum
van den Heuvel, R.H.; van den Berg, W.A.; Rovida, S.; van Berkel, W.J.
Laboratory-evolved vanillyl-alcohol oxidase produces natural vanillin
J. Biol. Chem.
279
33492-33500
2004
Penicillium simplicissimum (P56216)
van den Heuvel, R.H.; Fraaije, M.W.; Ferrer, M.; Mattevi, A.; van Berkel, W.J.
Inversion of stereospecificity of vanillyl-alcohol oxidase
Proc. Natl. Acad. Sci. USA
97
9455-9460
2000
Penicillium simplicissimum (P56216)
Overhage, J.; Steinbuechel, A.; Priefert, H.
Harnessing eugenol as a substrate for production of aromatic compounds with recombinant strains of Amycolatopsis sp. HR167
J. Biotechnol.
125
369-376
2006
Penicillium simplicissimum, Penicillium simplicissimum CBS 170.90
Jin, J.; Mazon, H.; van den Heuvel, R.H.; Heck, A.J.; Janssen, D.B.; Fraaije, M.W.
Covalent flavinylation of vanillyl-alcohol oxidase is an autocatalytic process
FEBS J.
275
5191-5200
2008
Penicillium simplicissimum (P56216)
Ewing, T.A.; Gygli, G.; van Berkel, W.J.
A single loop is essential for the octamerization of vanillyl alcohol oxidase
FEBS J.
283
2546-2559
2016
Penicillium simplicissimum (P56216)
Vinambres, M.; Espada, M.; Martinez, A.T.; Serrano, A.
Screening and evaluation of new hydroxymethylfurfural oxidases for furandicarboxylic acid production
Appl. Environ. Microbiol.
86
e00842
2020
Pseudomonas sp. 11/12A, Methylovorus sp. MP688 (E4QP00)
Colpa, D.I.; Loncar, N.; Schmidt, M.; Fraaije, M.W.
Creating oxidase-peroxidase fusion enzymes as a toolbox for cascade reactions
Chembiochem
18
2226-2230
2017
Rhodococcus jostii (Q0SBK1)
Jin, J.; Mazon, H.; van den Heuvel, R.H.H.; Janssen, D.B.; Fraaije, M.W.
Discovery of a eugenol oxidase from Rhodococcus sp. strain RHA1
FEBS J.
274
2311-2321
2007
Rhodococcus jostii (Q0SBK1)
Ewing, T.A.; Gygli, G.; van Berkel, W.J.H.
A single loop is essential for the octamerization of vanillyl alcohol oxidase
FEBS J.
283
2546-2559
2016
Penicillium simplicissimum (P56216)
Ewing, T.A.; Nguyen, Q.T.; Allan, R.C.; Gygli, G.; Romero, E.; Binda, C.; Fraaije, M.W.; Mattevi, A.; van Berkel, W.J.H.
Two tyrosine residues, Tyr-108 and Tyr-503, are responsible for the deprotonation of phenolic substrates in vanillyl-alcohol oxidase
J. Biol. Chem.
292
14668-14679
2017
Penicillium simplicissimum (P56216), Penicillium simplicissimum
Ewing, T.A.; van Noord, A.; Paul, C.E.; van Berkel, W.J.H.
A xylenol orange-based screening assay for the substrate specificity of flavin-dependent para-phenol oxidases
Molecules
23
164
2018
Penicillium simplicissimum (P56216)
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