1.1.3.15: (S)-2-hydroxy-acid oxidase

This is an abbreviated version!
For detailed information about (S)-2-hydroxy-acid oxidase, go to the full flat file.

Reaction

Synonyms

(L)-2-HAOX, (S)-2-hydroxy-acid oxidase, peroxisomal, 2-hydroxy acid oxidase, CSUB_C1080, EC 1.1.3.1, GLO, Glo1, GLO3, Glo4, glycolate oxidase, GO, GO1, GOX, GOX1, GOX2, HAO1, Hao2, HAOX, HAOX1, HAOX2, HAOX3, hydroxy-acid oxidase A, hydroxy-acid oxidase B, hydroxyacid oxidase 1, hydroxyacid oxidase A, L-2-hydroxy acid oxidase, L-2-hydroxyacid oxidase A, L-alpha-hydroxy acid oxidase, L-amino acid oxidase, L-LAC-OX, L-lactate monooxygenase, L-lactate oxidase, L-LOx, lactate oxidase, LCHAO, LctO, lHAOX1, lHAOX2, long chain hydroxy acid oxidase, long chain l-2-hydroxy acid oxidase, long chain L-2-hydroxy acid oxidase 2, long-chain 2-hydroxy acid oxidase, long-chain L-alpha-hydroxy acid oxidase, LOX, More, NbS00005125g0015, NbS00060838g0004, Nbv5tr6245008, Os03g0786100, Os04g0623500, Os07g0616500, oxidase, L-2-hydroxy acid, RCOM_0631490, RCOM_0684800

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.3 With oxygen as acceptor

                1.1.3.15 (S)-2-hydroxy-acid oxidase

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Results	in table
8	Activating Compound
4085	AA Sequence
19	Application
1	CAS Registry Number
32	Cloned(Commentary)
85	Cofactor
13	Crystallization (Commentary)
183	Disease/ Diagnostics
13	Expression
38	General Information
5	General Stability
104	IC50 Value
218	Inhibitors
3	kcat/KM [mM/s]
46	Ki Value [mM]
170	KM Value [mM]
48	Localization
5	Metals/Ions
33	Molecular Weight [Da]
145	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
131	Organism
7	Pathway
45	PDB ID
31	pH Optimum
4	pH Range
8	pH Stability
1	pI Value
1	Posttranslational Modification
29	Protein Variants
38	Purification (Commentary)
4	Reaction
4	Reaction Type
127	Reference
126	Source Tissue
25	Specific Activity [micromol/min/mg]
7	Storage Stability
273	Substrates and Products (Substrate)
32	Subunits
124	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
5	Temperature Stability [°C]
41	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.08

2-oxo-octanoate

Homo sapiens

Q9UJM8

-

685214

0.36

Bromopyruvate

Rattus sp.

-

transhydrogenation reaction

389685

1.9 - 2.1

DL-2-hydroxy-4-methylthiobutanoic acid

2 entries

0.76 - 2

DL-2-hydroxybutyrate

3 entries

54.1

flavin

Homo sapiens

Q9UJM8

pH 7.0, 30°C, flavin reduction

698951

1.04

glycerate

Spinacia oleracea

-

pH 8.0

677279

0.33 - 31.2

glycolate

8 entries

0.7 - 0.83

glyoxylate

2 entries

0.99

L-2-hydroxy octanoate

Rattus norvegicus

Q07523

-

671994

0.34

L-2-hydroxy palmitate

Rattus norvegicus

Q07523

-

671994

0.74

L-2-hydroxy-4-methylthiobutanoic acid

Gallus gallus

-

-

389677

2 - 2.4

L-2-Hydroxyisocaproate

2 entries

0.26 - 4.7

L-lactate

6 entries

0.014

L-leucine

Rattus sp.

-

isozymes beta1 and beta2

389680

0.11 - 2.51

L-Mandelate

3 entries

0.59 - 0.7

L-Phenyllactate

2 entries

0.52 - 4.7

O2

3 entries

additional information

additional information

3 entries

-

1.9

DL-2-hydroxy-4-methylthiobutanoic acid

Rattus sp.

-

isozyme beta2

389680

2.1

DL-2-hydroxy-4-methylthiobutanoic acid

Rattus sp.

-

isozyme beta1

389680

0.76

DL-2-hydroxybutyrate

Rattus sp.

-

-

389686

1.66

DL-2-hydroxybutyrate

Rattus sp.

-

isozyme beta1

389680

2

DL-2-hydroxybutyrate

Rattus sp.

-

isozyme beta2

389680

0.33

glycolate

Mycolicibacterium smegmatis

-

pH 7.0

440407

1

glycolate

Ricinus communis

B9S0Y9, B9ST74

pH 7.5, temperature not specified in the publication

763602

3.6

glycolate

Homo sapiens

-

-

684684

4.1

glycolate

Homo sapiens

Q9UJM8

-

685214

15.6

glycolate

Homo sapiens

-

-

684684

15.7

glycolate

Homo sapiens

Q9UJM8

pH 7.0, 30°C, recombinant enzyme, first order

698951

20

glycolate

Homo sapiens

Q9UJM8

pH 7.5, 30°C, recombinant enzyme, first order

698951

31.2

glycolate

Homo sapiens

Q9UJM8

pH 9.0, 30°C, recombinant enzyme, first order

698951

0.7

glyoxylate

Homo sapiens

Q9UJM8

-

685214

0.83

glyoxylate

Homo sapiens

-

-

684684

2

L-2-Hydroxyisocaproate

Rattus sp.

-

isozyme beta1

389680

2.4

L-2-Hydroxyisocaproate

Rattus sp.

-

isozyme beta2

389680

0.26

L-lactate

Rattus sp.

-

isozyme beta1

389680

0.38

L-lactate

Rattus sp.

-

isozyme beta2

389680

0.433

L-lactate

Rattus sp.

-

-

389700

0.46

L-lactate

Homo sapiens

-

-

684684

0.52

L-lactate

Aerococcus viridans

-

4°C, pH 7

440398

4.7

L-lactate

Aerococcus viridans

-

25°C, pH 7

440398

0.11

L-Mandelate

Homo sapiens

-

-

684684

1.55

L-Mandelate

Rattus sp.

-

isozyme beta1

389680

2.51

L-Mandelate

Rattus sp.

-

isozyme beta2

389680

0.59

L-Phenyllactate

Rattus sp.

-

isozyme beta1

389680

0.7

L-Phenyllactate

Rattus sp.

-

isozyme beta2

389680

0.52

O2

Aerococcus viridans

-

4°C, pH 7

440398

1.1

O2

Mycolicibacterium smegmatis

-

pH 7.0

440407

4.7

O2

Aerococcus viridans

-

25°C, pH 7

440398

additional information

additional information

Homo sapiens

Q9UJM8

a second-order rate constant for the capture of glycolate (kcat/Kglycolate) of 68300 M/s, and a second-order rate constant for reaction of the reduced flavin with oxygen (kcat/Koxygen) of 24500 Ms

698951

-

additional information

additional information

Homo sapiens

-

a second-order rate constant for the capture of glycolate (kcat/Kglycolate) of 68300 M/s, and a second-order rate constant for reaction of the reduced flavin with oxygen (kcat/Koxygen) of 24500 Ms

698951

-

additional information

additional information

Aerococcus viridans

-

reduction rate constants and dissociation constants for reaction of lactate oxidases with alpha-1H- and alpha-2H-para-substituted mandelates

440394

-