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1.1.1.B3: (S)-specific secondary alcohol dehydrogenase

This is an abbreviated version!
For detailed information about (S)-specific secondary alcohol dehydrogenase, go to the full flat file.

Reaction

(S)-R-CHOH-R'
+
NAD+
=
R-CO-R'
+
NADH
+
H+

Synonyms

(S)-1-phenylethanol dehydrogenase, (S)-1-phenylethanolsynthase, acetophenone reductase, ADH, ADH-A, ADH1, ADH2, ADHTt, APRD, carbonyl reductase (NADH, specific for (S)-configuration of alcohol), CRII, More, NAD+-dependent (S)-stereospecific alcohol dehydrogenase, NAD+-dependent ADH, PED, S-ADH, SADH, Scr2, SDR, short chain dehydrogenase, short-chain NAD(H)-dependent alcohol dehydrogenase, SOU1, SPES, TtADH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B3 (S)-specific secondary alcohol dehydrogenase

Reference

Reference on EC 1.1.1.B3 - (S)-specific secondary alcohol dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pennacchio, A.; Pucci, B.; Secundo, F.; La Cara, F.; Rossi, M.; Raia, C.A.
Purification and characterization of a novel recombinant highly enantioselective short-chain NAD(H)-dependent alcohol dehydrogenase from Thermus thermophilus
Appl. Environ. Microbiol.
74
3949-3958
2008
Thermus thermophilus
Manually annotated by BRENDA team
Abokitse, k.; Hummel, w.
Cloning, sequence analysis, and heterologous expression of the gene encoding a (S)-specific alcohol dehydrogenase from Rhodococcus erythropolis DSM 43297
Appl. Microbiol. Biotechnol.
62
380-386
2003
Rhodococcus erythropolis (Q6YBW1)
Manually annotated by BRENDA team
Hoeffken, H.W.; Duong, M.; Friedrich, T.; Breuer, M.; Hauer, B.; Reinhardt, R.; Rabus, R.; Heider, J.
Crystal structure and enzyme kinetics of the (S)-specific 1-phenylethanol dehydrogenase of the denitrifying bacterium strain EbN1
Biochemistry
45
82-93
2006
uncultured bacterium, uncultured bacterium EbN1
Manually annotated by BRENDA team
Yamamoto, H.; Matsuyama, A.; Kobayashi, Y.
Synthesis of (R)-1,3-butanediol by enantioselective oxidation using whole recombinant Escherichia coli cells expressing (S)-specific secondary alcohol dehydrogenase
Biosci. Biotechnol. Biochem.
4
925-927
2002
Candida parapsilosis
-
Manually annotated by BRENDA team
Xie, S.-X.; Ogawa, J.; Shimizu, S.
NAD+-Dependent (S)-specific secondary alcohol dehydrogenase involved in stereoinversion of 3-pentyn-2ol catalyzed by Nocardia fusca AKU 2123
Biosci. Biotechnol. Biochem.
63
1721-1729
1999
Nocardia fusca AKU 2123
Manually annotated by BRENDA team
Yamamoto, H.; Matsuyama, A.; Kobayashi, Y.
Synthesis of ethyl (R)-4-chloro-3-hydroxybutanoate with recombinant Escherichia coli cells expressing (S)-specific secondary alcohol dehydrogenase
Biosci. Biotechnol. Biochem.
66
481-483
2002
Candida parapsilosis
Manually annotated by BRENDA team
Soni, P.; Kansal, H.; Banerjee, U.C.
Purification and characterization of an enantioselective carbonyl reductase from Candida viswanathii MTCC 5158
Process Biochem.
42
1632-1640
2007
Candida viswanathii, Candida viswanathii MTCC 5158
-
Manually annotated by BRENDA team
Pal, S.; Park, D.H.; Plapp, B.V.
Activity of yeast alcohol dehydrogenases on benzyl alcohols and benzaldehydes: characterization of ADH1 from Saccharomyces carlsbergensis and transition state analysis
Chem. Biol. Interact.
178
16-23
2009
Saccharomyces cerevisiae, Saccharomyces pastorianus, Saccharomyces pastorianus Y379-50
Manually annotated by BRENDA team
Pennacchio, A.; Esposito, L.; Zagari, A.; Rossi, M.; Raia, C.A.
Role of Tryptophan 95 in substrate specificity and structural stability of Sulfolobus solfataricus alcohol dehydrogenase
Extremophiles
13
751-761
2009
Saccharolobus solfataricus
Manually annotated by BRENDA team
Rocha-Martin, J.; Vega, D.; Cabrera, Z.; Bolivar, J.; Fernandez-Lafuente, R.; Berenguer, J.; Guisan, J.
Purification, immobilization and stabilization of a highly enantioselective alcohol dehydrogenase from Thermus thermophilus HB27 cloned in E. coli
Process Biochem.
44
1004-1012
2009
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
Manually annotated by BRENDA team
Protsko, C.; Vieille, C.; Laivenieks, M.; Prasad, L.; Sanders, D.A.; Delbaere, L.T.
Crystallization and preliminary X-ray diffraction analysis of the Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase I86A mutant
Acta Crystallogr. Sect. F
66
831-833
2010
Thermoanaerobacter ethanolicus (P77990)
Manually annotated by BRENDA team
Cao, H.; Mi, L.; Ye, Q.; Zang, G.; Yan, M.; Wang, Y.; Zhang, Y.; Li, X.; Xu, L.; Xiong, J.; Ouyang, P.; Ying, H.
Purification and characterization of a novel NADH-dependent carbonyl reductase from Pichia stipitis involved in biosynthesis of optically pure ethyl (S)-4-chloro-3-hydroxybutanoate
Biores. Technol.
102
1733-1739
2011
Scheffersomyces stipitis (A3GF05)
Manually annotated by BRENDA team
Li, Y.; Xu, J.; Xu, Y.
Deracemization of aryl secondary alcohols via enantioselective oxidation and stereoselective reduction with tandem whole-cell biocatalysts
J. Mol. Catal. B
64
48-52
2010
Rhodotorula sp., Rhodotorula sp. AS2.2241
-
Manually annotated by BRENDA team
You, Z.Y.; Liu, Z.Q.; Zheng, Y.G.
Characterization of a newly synthesized carbonyl reductase and construction of a biocatalytic process for the synthesis of ethyl (S)-4-chloro-3-hydroxybutanoate with high space-time yield
Appl. Microbiol. Biotechnol.
98
1671-1680
2014
Candida parapsilosis (D5G304)
Manually annotated by BRENDA team
Cai, P.; An, M.; Xu, S.; Yan, M.; Hao, N.; Li, Y.; Xu, L.
Asymmetric synthesis of (S)-4-chloro-3-hydroxybutanoate by sorbose reductase from Candida albicans with two co-existing recombinant Escherichia coli strains
Biosci. Biotechnol. Biochem.
79
1090-1093
2015
Candida albicans (P87219), Candida albicans ATCC MYA-2876 (P87219)
Manually annotated by BRENDA team
Xu, G.C.; Shang, Y.P.; Yu, H.L.; Xu, J.H.
Identification of key residues in Debaryomyces hansenii carbonyl reductase for highly productive preparation of (S)-aryl halohydrins
Chem. Commun. (Camb.)
51
15728-15731
2015
Debaryomyces hansenii
Manually annotated by BRENDA team
Dudzik, A.; Snoch, W.; Borowiecki, P.; Opalinska-Piskorz, J.; Witko, M.; Heider, J.; Szaleniec, M.
Asymmetric reduction of ketones and beta-keto esters by (S)-1-phenylethanol dehydrogenase from denitrifying bacterium Aromatoleum aromaticum
Appl. Microbiol. Biotechnol.
99
5055-5069
2015
Aromatoleum aromaticum, Aromatoleum aromaticum EbN1
Manually annotated by BRENDA team
Schmermund, L.; Reischauer, S.; Bierbaumer, S.; Winkler, C.K.; Diaz-Rodriguez, A.; Edwards, L.J.; Kara, S.; Mielke, T.; Cartwright, J.; Grogan, G.; Pieber, B.; Kroutil, W.
Chromoselective photocatalysis enables stereocomplementary biocatalytic pathways
Angew. Chem. Int. Ed. Engl.
60
6965-6969
2021
Rhodococcus ruber
Manually annotated by BRENDA team
Koesoema, A.A.; Sugiyama, Y.; Sriwong, K.T.; Xu, Z.; Verina, S.; Standley, D.M.; Senda, M.; Senda, T.; Matsuda, T.
Reversible control of enantioselectivity by the length of ketone substituent in biocatalytic reduction
Appl. Microbiol. Biotechnol.
103
9529-9541
2019
Geotrichum candidum (M5A8V4), Geotrichum candidum, Geotrichum candidum NBRC 4597 (M5A8V4)
Manually annotated by BRENDA team
Zhou, Y.; Peng, Q.; Zhang, L.; Cheng, S.; Zeng, L.; Dong, F.; Yang, Z.
Characterization of enzymes specifically producing chiral flavor compounds (R)- and (S)-1-phenylethanol from tea (Camellia sinensis) flowers
Food Chem.
280
27-33
2019
Camellia sinensis (A0A494WD27), Camellia sinensis
Manually annotated by BRENDA team
Knaus, T.; Cariati, L.; Masman, M.F.; Mutti, F.G.
In vitro biocatalytic pathway design orthogonal network for the quantitative and stereospecific amination of alcohols
Org. Biomol. Chem.
15
8313-8325
2017
Thermoanaerobacter ethanolicus
Manually annotated by BRENDA team