1.1.1.88: hydroxymethylglutaryl-CoA reductase

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase, go to the full flat file.

Word Map on EC 1.1.1.88

1.1.1.88

cholesterol

statin

lipoprotein

simvastatin

sterol

low-density

coronary

cardiovascular

lovastatin

hypercholesterolemia

pravastatin

atorvastatin

lipid-lowering

cholesterol-lowering

3-hydroxy-3-methylglutaryl-coa

cerivastatin

mevinolin

alpha-hydroxylase

statin-induced

compactin

mevalonolactone

cholestyramine

mevalonii

lipoprotein-deficient

medicine

25-hydroxycholesterol

fibric

Reaction

+ 2 NAD⁺ =

+ 2 NADH + 2 H+

Synonyms

3-hydroxy-3-methylglutaryl CoA reductase 1, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, HMG-CoA reductase, HMGCoAR, HMGR, hydroxymethylglutaryl coenzyme A reductase, Mt HMGR1, mvaA, NADH-dependent HMG-CoA reductase, NADH-HMGR

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.88 hydroxymethylglutaryl-CoA reductase

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Results	in table
5	Activating Compound
5616	AA Sequence
3	Application
1	CAS Registry Number
11	Cloned(Commentary)
49	Cofactor
5	Crystallization (Commentary)
492	Disease/ Diagnostics
2	Expression
6	General Information
9	General Stability
2	IC50 Value
38	Inhibitors
2	kcat/KM [mM/s]
10	Ki Value [mM]
59	KM Value [mM]
7	Localization
1	Metals/Ions
8	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
36	Organism
5	Pathway
32	PDB ID
18	pH Optimum
2	Posttranslational Modification
26	Protein Variants
6	Purification (Commentary)
3	Reaction
5	Reaction Type
36	Reference
1	Renatured (Commentary)
12	Source Tissue
23	Specific Activity [micromol/min/mg]
5	Storage Stability
49	Substrates and Products (Substrate)
7	Subunits
32	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Turnover Number [1/s]

Engineering

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Engineering on EC 1.1.1.88 - hydroxymethylglutaryl-CoA reductase

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Go to Protein Variants Search

S871A

Mesocricetus auratus

150% of wild-type activity in 50 mM KCl

287503

C156/296 A