1.1.1.85: 3-isopropylmalate dehydrogenase
This is an abbreviated version!
For detailed information about 3-isopropylmalate dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.85
Reaction
Synonyms
2-hydroxy-4-methyl-3-carboxyvalerate:NAD+ oxidoreductase, 2R,3S-isopropylmalate:NAD+ oxidoreductase (decaboxylating), 3-IPM dehydrogenase, 3-IPM-DH, 3-isopropylmalate dehydrogenase, 3-isopropylmalateDH, APS IPMDH, beta-IPM dehydrogenase, beta-IPMDH, beta-isopropylmalate dehydrogenase, beta-isopropylmalic enzyme, Bs3-isopropylmalateDH, dehydrogenase, 3-isopropylmalate, IMDH, IPMDH, IPMDH1, IPMDH2, IPMDH3, isopropylmalate dehydrogenase, leuB, NAD-dependent isopropylmalate dehydrogenase, Saci_0600, SbIPMDH, SoIPMDH, threo-Ds-3-isopropylmalate dehydrogenase, Tt-beta-3-isopropylmalateDH, two-domain 3-isopropylmalate dehydrogenase, Ydr417cp
ECTree
1.1.1.85 3-isopropylmalate dehydrogenaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
NADH
-
NADH always produces competitive inhibition patterns with respect to NAD and noncompetitive inhibition patterns with respect to the substrates
O-isobutenyl oxalylhydroxamate
competitive inhibitor, binds the active site by adopting the same conformation of (2R,3S)-3-isopropylmalate, and to induce an unreported repositioning of the side chain of the amino acids that participate in the coordination of the ligand
-
O-isobutenyloxalylhydroxamate
O-isobutenyloxalylhydroxamate binds to the active site of enzyme in a mode similar to the substrate isopropylmalate
iodoacetamide
-
50 mM, slight inhibition
iodoacetate
-
50 mM, slight inhibition
K+
-
above 1 M, slight inhibition
NEM
-
5 mM, 50% inhibition, not reversed by 2-mercaptoethanol
p-hydroxymercuribenzoate
-
pH 9.0, 2 mM, complete inhibition, reversed by 2-mercaptoethanol
