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1.1.1.79: glyoxylate reductase (NADP+)

This is an abbreviated version!
For detailed information about glyoxylate reductase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.79

Reaction

D-glycerate
+
NAD(P)+
=
glyoxylate
+
NADPH
+
H+

Synonyms

aac4036, At3g25530, AtGLYR1, AtGLYR2, AtGR1, AtGR2, D-2-hydroxy-acid dehydrogenase, GhrA, glycerate dehydrogenase, glyoxylate reductase, glyoxylate reductase 1, glyoxylate reductase 2, glyoxylate reductase isoform 1, glyoxylate reductase/hydroxypyruvate reductase, glyoxylate/succinic semialdehyde reductase, GLYR1, GLYR2, GOR1, Gor1p, GR/HPR, GR1, GR2, GRHPR, GRHRP, HPR2, HPR3, More, NAD(P)H-dependent GR, NADPH/NADH-dependent glyoxylate/hydroxypyruvate reductases, PfuGRHPR, PhoGRHPR, PtGR, PyaGRHPR, TthGR1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.79 glyoxylate reductase (NADP+)

Inhibitors

Inhibitors on EC 1.1.1.79 - glyoxylate reductase (NADP+)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
4-hydroxybutyrate
mixed type inhibition with NADPH; mixed type inhibition with succinic semialdehyde
adenine
-
0.01 mM, 70% inhibition after preincubation for 5 min
alpha-ketoglutarate
-
5 mM, 57% inhibition
Carbonate
-
20 mM, 7-16% inhibition
chloride
-
20 mM, 7-16% inhibition
cyanide
-
2 mM, 46% inhibition, 20 mM, 92% inhibition
cysteine
-
isoenzyme 1, 1 mM, 29% inhibition
D-glycerate
-
the enzyme shows product inhibition
diethyldicarbonate
-
1 mM, 33% inhibition, incubation for 1 min
dithiothreitol
ethanol
-
enzyme activity is decreased to 20% by incubation with 60% (v/v) ethanol
Fe3+
-
15% inhibition at 1 mM
glutathione
-
isoenzyme 1, 1 mM, 12% inhibition
glycidate
-
10 mM, 35% inhibition after 15 min
glycolate
Hg2+
-
30% inhibition at 1 mM
iodoacetamide
iodoacetate
-
isoenzyme 2, 1 mM, 97% inhibition, isoenzyme 1, 1 mM, 18% inhibition
N-ethylmaleimide
NaCl
-
complete inhibition at 0.5 M
NADP+
nitrate
nitrite
-
20 mM, 7-16% inhibition
oxalate
-
when using NADPH as cofactor, the Ki value of oxalate for isoform GR1 is 21.2 mM and that for isoform GR2 is 290.8 mM. When using NADH as cofactor, the Ki values of oxalate are much lower, 3.6mM for isoform GR1, and 8.2mM for isoform GR2
p-chloromercuribenzoate
PMSF
-
1 mM, 30% inhibition, incubation for 1 min
pyruvate
-
5 mM, 33% inhibition
Sodium fluoride
-
isoenzyme 1, 10 mM, 32% inhibition
sodium iodide
-
isoenzyme 1, 50 mM, 37% inhibition of glyoxylate reduction
Sodium phosphate
-
50% inhibition at 900 mM
additional information
-