1.1.1.42: isocitrate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about isocitrate dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

AbIDH1, AfIDH, CgIDH, cICDH, CtIDP1, CtIDP2, cytosolic isocitrate dehydrogenase 1, cytosolic NADP(+)-dependent isocitrate dehydrogenase, cytosolic NADP+-dependent isocitrate dehydrogenase, cytosolic NADP-dependent isocitrate dehydrogenase, cytosolic NADPH-dependent isocitrate dehydrogenase, DpIDH, EcIDH, HICDH, ICD, ICD1, ICD2, icdA, ICDH, ICDH-1, IDH, IDH-90, IDH-I, IDH-IIa, IDH-IIb, IDH1, IDH2, IDH3, IDHP, IDP, IDP1, IDP2, IDP3, IDPA, IDPc, IDPm, isocitrate dehydrogenase, isocitrate dehydrogenase (NADP), isocitrate dehydrogenase (NADP-dependent), isocitrate dehydrogenase (nicotinamide adenine dinucleotide phosphate), isocitrate dehydrogenase 1, isocitrate dehydrogenase 2, isocitrate dehydrogenase-1, isocytrate deyhdrogenase, mICDH, mitochondrial NADP+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, NADP+ dependent isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate:NADP+ oxidoreductase, NADP+-dependent ICDH, NADP+-dependent IDH, NADP+-dependent isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, NADP+-isocitrate dehydrogenase, NADP+-linked isocitrate dehydrogenase, NADP+-specific ICDH, NADP+-specific IDH, NADP+-specific isocitrate dehydrogenase, NADP-dependent IDH, NADP-dependent isocitrate dehydrogenase, NADP-dependent isocitric dehydrogenase, NADP-ICDH, NADP-IDH, NADP-IDH Idp1p, NADP-isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-specific isocitrate dehydrogenase, NADPH-dependent isocitrate dehydrogenase, NADPH-IDH, oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, perICDH, PS-NADP-IDH, TaIDH, TM1148, YlIDP

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.42 isocitrate dehydrogenase (NADP+)

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Results	in table
23	Activating Compound
48084	AA Sequence
13	Application
1	CAS Registry Number
74	Cloned(Commentary)
180	Cofactor
21	Crystallization (Commentary)
2617	Disease/ Diagnostics
11	Expression
64	General Information
12	General Stability
16	IC50 Value
242	Inhibitors
136	kcat/KM [mM/s]
35	Ki Value [mM]
463	KM Value [mM]
143	Localization
166	Metals/Ions
123	Molecular Weight [Da]
180	Natural Substrates/ Products (Substrates)
279	Organism
2	Oxidation Stability
22	Pathway
294	PDB ID
95	pH Optimum
22	pH Range
4	pH Stability
20	pI Value
8	Posttranslational Modification
185	Protein Variants
90	Purification (Commentary)
10	Reaction
3	Reaction Type
246	Reference
9	Renatured (Commentary)
178	Source Tissue
72	Specific Activity [micromol/min/mg]
6	Storage Stability
289	Substrates and Products (Substrate)
126	Subunits
355	Synonyms
1	Systematic Name
84	Temperature Optimum [°C]
13	Temperature Range [°C]
70	Temperature Stability [°C]
185	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+)

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POSTTRANSLATIONAL MODIFICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

acetylation

Homo sapiens

P48735

SIRT3 deacetylates isoform IDH2

762409

glutathionylation

2 entries

nitration

Capsicum annuum

A0A2G2Y555

the enzyme protein is a target of inhibitory nitric oxide-mediated posttranslational modification (nitration)

762026

phosphoprotein

2 entries

S-nitrosylation

2 entries

glutathionylation

Arabidopsis thaliana

Q9SRZ6

S-glutathionylation of Cys363 is involved in the inhibition of the cytosolic enzyme activity upon nitrosoglutathione treatments

760361

glutathionylation

Homo sapiens

-

Cys269 of IDPc is a target for S-glutathionylation, this modification is reversed by dithiothreitol as well as enzymatically by cytosolic glutaredoxin in the presence of glutathione. Glutathionylated IDPc is significantly less susceptible than native protein to peptide fragmentation by reactive oxygen species and proteolytic digestion. Glutathionylation may play a protective role in the degradation of protein through the structural alterations of IDPc.

698059

phosphoprotein

Acinetobacter baumannii

V5VCI0

the enzyme is phosphorylated at Ser113 by Escherichia coli isocitrate dehydrogenase kinase/phosphatase

760653

phosphoprotein

Sus scrofa

A0A4X1UZU9

tyrosine phosphorylated enzyme shows a significantly lowered enzymatic activity

760487

S-nitrosylation

Arabidopsis thaliana

Q9SRZ6

-

760361

S-nitrosylation

Capsicum annuum

A0A2G2Y555

the enzyme protein is a target of inhibitory H2S-mediated posttranslational modification (S-nitrosylation)

762026