1.1.1.413: A-factor type gamma-butyrolactone 1'-reductase (1S-forming)

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For detailed information about A-factor type gamma-butyrolactone 1'-reductase (1S-forming), go to the full flat file.

Reaction

Synonyms

BARS1, Virginiae butanolide-specific dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.413 A-factor type gamma-butyrolactone 1'-reductase (1S-forming)

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Results	in table
16	AA Sequence
1	Cloned(Commentary)
2	Cofactor
1	KM Value [mM]
1	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
3	Organism
1	Pathway
1	pH Optimum
1	Reaction
3	Reference
14	Substrates and Products (Substrate)
4	Subunits
5	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 1.1.1.413 - A-factor type gamma-butyrolactone 1'-reductase (1S-forming)

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SYSTEMATIC NAME

IUBMB Comments

(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one:NADP+ 1'-oxidoreductase

The enzyme, which is found in bacteria that produce virginiae-butanolide (VB) type gamma-butyrolactone autoregulators, reduces its substrate stereospecifically, forming a hydroxyl group in the (S) configuration.