1.1.1.41: isocitrate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about isocitrate dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

At2g17130, At4g35260, At4g35650, At5g03290, AtIDH I, AtIDH II, AtIDH V, AtIDH VI, beta-decarboxylating dehydrogenase, beta-ketoglutaric-isocitric carboxylase, CaIDH, CcIDH, hNAD-IDHalpha, homodimeric NAD+-linked isocitrate dehydrogenase, Icd-2, ICDH, ICDH1, IDH, IDH I, IDH II, IDH III, IDH IV, IDH V, IDH-50, IDH-I, IDH-II, IDH-V, IDH1, IDH2, IDH3, IDH3A, IDH3alpha, IDH5, IDHa, isocitrate dehydrogenase, isocitrate dehydrogenase 2, isocitrate dehydrogenase 3alpha subunit, isocitrate-homoisocitrate dehydrogenase, isocitric acid dehydrogenase, isocitric dehydrogenase, McIDH, mIDH, MiIDH, mitochondrial NAD-dependent isocitrate dehydrogenase, monomeric NAD-IDH, NAD dependent isocitrate dehydrogenase, NAD isocitrate dehydrogenase, NAD isocitric dehydrogenase, NAD(P)+-dependent isocitrate dehydrogenase, NAD+-dependent ICDH, NAD+-dependent IDH, NAD+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase 1, NAD+-dependent isocitrate dehydrogenase 3, NAD+-dependent type 1 IDH, NAD+-IDH, NAD+-specific ICDH, NAD+-specific IDH, NAD+-specific isocitrate dehydrogenase, NAD-Dependent IDH, NAD-dependent isocitrate dehydrogenase, NAD-ICDH, NAD-IDH, NAD-isocitrate dehydrogenase, NAD-linked isocitrate dehydrogenase, NAD-specific isocitrate dehydrogenase, NADH-IDH, OlIDH, OtIDH, PF0202, PH1722, Rv0066c, threo-DS-isocitrate:NAD+ oxidoreductase (decarboxylating), type 1 isocitrate dehydrogenase, type II homodimeric NAD-IDH, type II NAD+-specific isocitrate dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.41 isocitrate dehydrogenase (NAD+)

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Results	in table
31	Activating Compound
1745	AA Sequence
1	Application
1	CAS Registry Number
45	Cloned(Commentary)
108	Cofactor
10	Crystallization (Commentary)
4327	Disease/ Diagnostics
3	Expression
45	General Information
9	General Stability
3	IC50 Value
160	Inhibitors
63	kcat/KM [mM/s]
5	Ki Value [mM]
163	KM Value [mM]
40	Localization
90	Metals/Ions
71	Molecular Weight [Da]
101	Natural Substrates/ Products (Substrates)
357	Organism
9	Pathway
80	PDB ID
44	pH Optimum
9	pH Range
1	pH Stability
3	pI Value
2	Posttranslational Modification
124	Protein Variants
56	Purification (Commentary)
2	Reaction
5	Reaction Type
138	Reference
1	Renatured (Commentary)
127	Source Tissue
42	Specific Activity [micromol/min/mg]
5	Storage Stability
175	Substrates and Products (Substrate)
74	Subunits
231	Synonyms
1	Systematic Name
43	Temperature Optimum [°C]
8	Temperature Range [°C]
22	Temperature Stability [°C]
90	Turnover Number [1/s]

Storage Stability

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Storage Stability on EC 1.1.1.41 - isocitrate dehydrogenase (NAD+)

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-80°C, partially purified enzyme, several months, stable

Pisum sativum

-

654843

-90�C, no loss of activity after 6 weeks

2 entries

4°C, glycerol 20%, 35-40% of original activity after 96 h, membrane-associated ICDH

Pisum sativum

-

286774

4°C, recombinant wild-type enzyme, in affinity elution buffer containing 50 mM sodium phosphate, pH 7.5, 300 mM NaCl, and 200 mM imidazole, stable for several weeks

Saccharomyces cerevisiae

-

656052

-90�C, no loss of activity after 6 weeks

Sus scrofa

-

286751

-90�C, no loss of activity after 6 weeks

Bos taurus

-

286752