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1.1.1.41: isocitrate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about isocitrate dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.41

Reaction

isocitrate
+
NAD+
=
2-oxoglutarate
 +
CO2
 +
NADH
 +
H+

Synonyms

At2g17130, At4g35260, At4g35650, At5g03290, AtIDH I, AtIDH II, AtIDH V, AtIDH VI, beta-decarboxylating dehydrogenase, beta-ketoglutaric-isocitric carboxylase, CaIDH, CcIDH, hNAD-IDHalpha, homodimeric NAD+-linked isocitrate dehydrogenase, Icd-2, ICDH, ICDH1, IDH, IDH I, IDH II, IDH III, IDH IV, IDH V, IDH-50, IDH-I, IDH-II, IDH-V, IDH1, IDH2, IDH3, IDH3A, IDH3alpha, IDH5, IDHa, isocitrate dehydrogenase, isocitrate dehydrogenase 2, isocitrate dehydrogenase 3alpha subunit, isocitrate-homoisocitrate dehydrogenase, isocitric acid dehydrogenase, isocitric dehydrogenase, McIDH, mIDH, MiIDH, mitochondrial NAD-dependent isocitrate dehydrogenase, monomeric NAD-IDH, NAD dependent isocitrate dehydrogenase, NAD isocitrate dehydrogenase, NAD isocitric dehydrogenase, NAD(P)+-dependent isocitrate dehydrogenase, NAD+-dependent ICDH, NAD+-dependent IDH, NAD+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase 1, NAD+-dependent isocitrate dehydrogenase 3, NAD+-dependent type 1 IDH, NAD+-IDH, NAD+-specific ICDH, NAD+-specific IDH, NAD+-specific isocitrate dehydrogenase, NAD-Dependent IDH, NAD-dependent isocitrate dehydrogenase, NAD-ICDH, NAD-IDH, NAD-isocitrate dehydrogenase, NAD-linked isocitrate dehydrogenase, NAD-specific isocitrate dehydrogenase, NADH-IDH, OlIDH, OtIDH, PF0202, PH1722, Rv0066c, threo-DS-isocitrate:NAD+ oxidoreductase (decarboxylating), type 1 isocitrate dehydrogenase, type II homodimeric NAD-IDH, type II NAD+-specific isocitrate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.41 isocitrate dehydrogenase (NAD+)

Reference

topprint

Reference on EC 1.1.1.41 - isocitrate dehydrogenase (NAD+)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Plaut, G.W.E.
Isocitrate dehydrogenase
The Enzymes, 2nd Ed. (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. )
7
105-126
1963
Aspergillus niger, Bos taurus, Saccharomyces cerevisiae, Cavia porcellus, Columba livia, Homo sapiens, Pisum sativum, Rattus norvegicus
-
Manually annotated by BRENDA team
Glaeser, H.; Schlegel, H.G.
NADP- und NAD-spezifische dehydrogenase in Hydrogenomas eutropha stamm H 16
Arch. Microbiol.
86
327-337
1972
Cupriavidus necator
Manually annotated by BRENDA team
Cohen, P.F.; Colman, R.F.
Role of manganous ion in the kinetics of pig-heart NAD-specific isocitrate dehydrogenase
Eur. J. Biochem.
47
35-45
1974
Sus scrofa
Manually annotated by BRENDA team
Silinski, J.M.; Colman, R.F.
The kinetics of NAD-linked isocitrate dehydrogenase from calf heart
Biochim. Biophys. Acta
370
1-25
1974
Bos taurus
Manually annotated by BRENDA team
Alp, P.R.; Newsholme, E.A.; Zammit, V.A.
Activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates
Biochem. J.
154
689-700
1976
Lepas anatifera, Locusta sp., Oryctes rhinoceros, Ovis aries, Periplaneta americana, Sarcophaga barbata, waterbug
Manually annotated by BRENDA team
Nabeshima, S.; Ishiyama, S.; Tanaka, A.; Fukui, S.
Partial purification and some kinetic properties of NAD-linked and NADP-linked isocitrate dehydrogenase from Candida tropicalis
Agric. Biol. Chem.
41
509-516
1977
Candida tropicalis
-
Manually annotated by BRENDA team
Ramachandran, N.; Colman, R.F.
Evidence for the presence of two nonidentical subunits in NAD-dependent isocitrate dehydrogenase of pig heart
Proc. Natl. Acad. Sci. USA
75
252-255
1978
Sus scrofa
Manually annotated by BRENDA team
Hoffmann, K.H.; Babel, W.
Regulation of NAD+- and NADP+-linked isocitrate dehydrogenase in the obligate methylotrophic bacterium Pseudomonas W6
Z. Allg. Mikrobiol.
20
399-404
1980
Pseudomonas sp., Pseudomonas sp. W 6
Manually annotated by BRENDA team
Willson, V.J.C.; Tripton, K.F.
The effect of pH on the allosteric behaviour of ox-brain NAD+-dependent isocitrate dehydrogenase
Eur. J. Biochem.
109
411-416
1980
Bos taurus
Manually annotated by BRENDA team
Willson, V.J.C.; Tripton, K.F.
The activation of ox-brain NAD+-dependent isocitrate dehydrogenase by magnesium ions
Eur. J. Biochem.
113
477-483
1981
Bos taurus
Manually annotated by BRENDA team
Ehrlich, R.S.; Hayman, S.; Ramachandran, N.; Colman, R.F.
Re-evaluation of molecular weight of pig heart NAD-specific isocitrate dehydrogenase
J. Biol. Chem.
256
10560-10564
1981
Sus scrofa
Manually annotated by BRENDA team
Gabriel, J.L.; Plaut, G.W.E.
Specific site inhibitors of NAD-specific isocitrate dehydrogenase from bovine heart
J. Biol. Chem.
257
8021-8029
1981
Bos taurus
Manually annotated by BRENDA team
Tezuka, T.; Laties, G.G.
Isolation and characterization of inner membrane-associated and matrix NAD-specific isocitrate dehydrogenase in potato mitochondria
Plant Physiol.
72
959-963
1982
Solanum tuberosum
Manually annotated by BRENDA team
Gabriel, J.L.; Plaut, G.W.E.
Inhibition of bovine heart NAD-specific isocitrate dehydrogenase by reduced pyridine nucleotides: modulation of inhibition by ADP, NAD+, Ca2+, citrate, and isocitrate
Biochemistry
23
2773-2778
1984
Bos taurus
Manually annotated by BRENDA team
Bulos, B.A.; Thomas, B.J.; Sacktor, B.
Calcium inhibition of the NAD+-linked isocitrate dehydrogenase from blowfly flight muscle mitochondria
J. Biol. Chem.
259
10232-10237
1984
Phormia regina
Manually annotated by BRENDA team
Gabriel, J.L.; Milner, R.; Plaut, G.W.E.
Inhibition and activation of bovine heart NAD-specific isocitrate dehydrogenase by ATP
Arch. Biochem. Biophys.
240
128-134
1985
Bos taurus
Manually annotated by BRENDA team
Gabriel, J.L.; Plaut, G.W.E.
NAD-specific isocitrate dehydrogenase from bovine heart. Interaction with Ca2+ chelators
Biochem. J.
229
817-822
1985
Bos taurus
Manually annotated by BRENDA team
Evans, C.T.; Ratledge, C.
The role of the mitochondrial NAD+:isocitrate dehydrogenase in lipid accumulation by the oleaginous yeast Rhodosporidium toruloides CBS 14
Can. J. Microbiol.
31
845-850
1985
Rhodotorula toruloides
-
Manually annotated by BRENDA team
Rutter, G.A.; Denton, R.M.
Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+ ions within toluene-permeabilized rat heart mitochondria. Interactions with regulation by adenine nucleotides and NADH/NAD+ ratios [published erratum appears in Biochem J 1988 Aug 1;253(3):935]
Biochem. J.
252
181-189
1988
Rattus norvegicus
Manually annotated by BRENDA team
Gabriel, J.L.; Plaut, G.W.E.
Citrate activation of NAD-specific isocitrate dehydrogenase from bovine heart
J. Biol. Chem.
259
1622-1628
1984
Bos taurus
Manually annotated by BRENDA team
Kim, Y.O.; Koh, H.J.; Kim, S.H.; Jo, S.H.; Huh, J.W.; Jeong, K.S.; Lee, I.J.; Song, B.J.; Huh, T.L.
Identification and functional characterization of a novel tissue-specific NAD+-dependent isocitrate dehydrogenase beta subunit isoform
J. Biol. Chem.
274
36866-36875
1999
Homo sapiens
Manually annotated by BRENDA team
Gabriel, J.L.; Plaut, G.W.E.
Kinetic regulation of yeast NAD-specific isocitrate dehydrogenase by citrate
Biochemistry
30
2594-2599
1991
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Panisko, E.A.; McAllister-Henn, L.
Subunit interactions of yeast NAD+-specific isocitrate dehydrogenase
J. Biol. Chem.
276
1204-1210
2001
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Anderson, S.L.; Minard, K.I.; McAllister-Henn, L.
Allosteric inhibition of NAD+-specific isocitrate dehydrogenase by a mitochondrial mRNA
Biochemistry
39
5623-5629
2000
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Martinez-Rivas, J.M.; Vega, J.M.
Purification and characterization of NAD-isocitrate dehydrogenase from Chlamydomonas reinhardtii
Plant Physiol.
118
249-255
1998
Chlamydomonas reinhardtii
Manually annotated by BRENDA team
McIntosh, C.A.
Partial purification and characteristics of membrane-associated NAD+-dependent isocitrate dehydrogenase activity from etiolated pea mitochondria
Plant Sci.
129
9-20
1997
Pisum sativum
-
Manually annotated by BRENDA team
Huang, Y.C.; Kumar, A.; Colman, R.F.
Identification of the subunits and target peptides of pig heart NAD-specific isocitrate dehydrogenase modified by the affinity label 8-(4-bromo-2,3-dioxobutylthio)NAD
Arch. Biochem. Biophys.
348
207-218
1997
Sus scrofa
Manually annotated by BRENDA team
Alvarez-Villafane, E.; Soler, J.; del Valle, P.; Busto, F.; de Arriaga, D.
Two NAD+-dependent isocitrate dehydrogenase forms in Phycomyces blakesleeanus. Induction in response to acetate growth and characterization, kinetics, and regulation of both enzyme forms
Biochemistry
35
4741-4752
1996
Phycomyces blakesleeanus
Manually annotated by BRENDA team
Hurley, J.H.; Chen, R.; Dean, A.M.
Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP+ to NAD+ specificity-reversal mutant
Biochemistry
35
5670-5678
1996
Escherichia coli
Manually annotated by BRENDA team
Anderson, S.L.; Schirf, V.; McAlister-Henn, L.
Effect of AMP on mRNA binding by yeast NAD+-specific isocitrate dehydrogenase
Biochemistry
41
7065-7073
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Morgunov, I.G.; Solodovnikova, N.Y.; Sharyshev, A.A.; Kamzolova, S.V.; Finogenova, T.V.
Regulation of NAD(+)-dependent isocitrate dehydrogenase in the citrate producing yeast Yarrowia lipolytica
Biochemistry
69
1391-1398
2004
Yarrowia lipolytica
Manually annotated by BRENDA team
Igamberdiev, A.U.; Gardestrom, P.
Regulation of NAD- and NADP-dependent isocitrate dehydrogenases by reduction levels of pyridine nucleotides in mitochondria and cytosol of pea leaves
Biochim. Biophys. Acta
1606
117-125
2003
Pisum sativum
Manually annotated by BRENDA team
Pinheiro de Carvalho, M.A.A.; Popova, T.N.; Dos Santos, T.M.M.; Zherebtsov, N.A.
Effect of metabolites of gamma-aminobutyric shunt on activities of NAD- and NADP-isocitrate dehydrogenases and aconitate hydratase from higher plants
Biol. Bull.
30
236-242
2003
Pisum sativum, Zea mays
-
Manually annotated by BRENDA team
Inoue, H.; Tamura, T.; Ehara, N.; Nishito, A.; Nakayama, Y.; Maekawa, M.; Imada, K.; Tanaka, H.; Inagaki, K.
Biochemical and molecular characterization of the NAD(+)-dependent isocitrate dehydrogenase from the chemolithotroph Acidithiobacillus thiooxidans
FEMS Microbiol. Lett.
214
127-132
2002
Acidithiobacillus thiooxidans (Q8GAX0), Acidithiobacillus thiooxidans, Acidithiobacillus thiooxidans ON107 (Q8GAX0)
Manually annotated by BRENDA team
Lin, A.P.; McAlister-Henn, L.
Isocitrate binding at two functionally distinct sites in yeast NAD+-specific isocitrate dehydrogenase
J. Biol. Chem.
277
22475-22483
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lin, A.P.; McAlister-Henn, L.
Homologous binding sites in yeast isocitrate dehydrogenase for cofactor (NAD+) and allosteric activator (AMP)
J. Biol. Chem.
278
12864-12872
2003
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Soundar, S.; Park, J.H.; Huh, T.L.; Colman, R.F.
Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase
J. Biol. Chem.
278
52146-52153
2003
Homo sapiens
Manually annotated by BRENDA team
Lin, M.; Behal, R.H.; Oliver, D.J.
Characterization of a mutation in the IDH-II subunit of the NAD+-dependent isocitrate dehydrogenase from Arabidopsis thaliana
Plant Sci.
166
983-988
2004
Arabidopsis thaliana, Arabidopsis thaliana Landsberg
Manually annotated by BRENDA team
Miyazaki, K.
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase
Biochem. Biophys. Res. Commun.
331
341-346
2005
Pyrococcus horikoshii
Manually annotated by BRENDA team
Mitchell, C.G.
Identification of a multienzyme complex of the tricarboxylic acid cycle enzymes containing citrate synthase isoenzymes from pseudomonas aeruginosa
Biochem. J.
313
769-774
1996
Pseudomonas aeruginosa
-
Manually annotated by BRENDA team
Hu, G.; Taylor, A.B.; McAlister-Henn, L.; Hart, P.J.
Crystallization and preliminary x-ray crystallographic analysis of yeast NAD+-specific isocitrate dehydrogenase. [Erratum to document cited in CA143:301281]
Acta Crystallogr. Sect. F
F62
709
2006
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Hu, G.; McAlister-Henn, L.
Novel allosteric properties produced by residue substitutions in the subunit interface of yeast NAD+-specific isocitrate dehydrogenase
Arch. Biochem. Biophys.
453
207-216
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P28241), Saccharomyces cerevisiae (P28834), Saccharomyces cerevisiae MMY011
Manually annotated by BRENDA team
Anderson, S.L.; Lin, A.P.; McAlister-Henn, L.
Analysis of interactions with mitochondrial mRNA using mutant forms of yeast NAD(+)-specific isocitrate dehydrogenase
Biochemistry
44
16776-16784
2005
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Manually annotated by BRENDA team
Hu, G.; Lin, A.P.; McAlister-Henn, L.
Physiological consequences of loss of allosteric activation of yeast NAD+-specific isocitrate dehydrogenase
J. Biol. Chem.
281
16935-16942
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Manually annotated by BRENDA team
Soundar, S.; Ohagan, M.; Fomulu, K.S.; Colman, R.F.
Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase
J. Biol. Chem.
281
21073-21081
2006
Homo sapiens
Manually annotated by BRENDA team
Watanabe, S.; Yasutake, Y.; Tanaka, I.; Takada, Y.
Elucidation of stability determinants of cold-adapted monomeric isocitrate dehydrogenase from a psychrophilic bacterium, Colwellia maris, by construction of chimeric enzymes
Microbiology
151
1083-1094
2005
Azotobacter vinelandii, Colwellia maris
Manually annotated by BRENDA team
Abiko, T.; Obara, M.; Ushioda, A.; Hayakawa, T.; Hodges, M.; Yamaya, T.
Localization of NAD-isocitrate dehydrogenase and glutamate dehydrogenase in rice roots: candidates for providing carbon skeletons to NADH-glutamate synthase
Plant Cell Physiol.
46
1724-1734
2005
Oryza sativa
Manually annotated by BRENDA team
Lemaitre, T.; Hodges, M.
Expression analysis of Arabidopsis thaliana NAD-dependent isocitrate dehydrogenase genes shows the presence of a functional subunit that is mainly expressed in the pollen and absent from vegetative organs
Plant Cell Physiol.
47
634-643
2006
Arabidopsis thaliana, Arabidopsis thaliana (O81796), Arabidopsis thaliana (P93032), Arabidopsis thaliana (Q8LFC0), Arabidopsis thaliana (Q8LG77), Arabidopsis thaliana (Q945K7)
Manually annotated by BRENDA team
Rodriguez-Arnedo, A.; Camacho, M.; Llorca, F.; Bonete, M.J.
Complete reversal of coenzyme specificity of isocitrate dehydrogenase from Haloferax volcanii
Protein J.
24
259-266
2005
Escherichia coli
Manually annotated by BRENDA team
Kalinina, O.V.; Gelfand, M.S.
Amino acid residues that determine functional specificity of NADP- and NAD-dependent isocitrate and isopropylmalate dehydrogenases
Proteins
64
1001-1009
2006
Escherichia coli
Manually annotated by BRENDA team
Lin, A.P.; Hakala, K.W.; Weintraub, S.T.; McAlister-Henn, L.
Suppression of metabolic defects of yeast isocitrate dehydrogenase and aconitase mutants by loss of citrate synthase
Arch. Biochem. Biophys.
474
205-212
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Manually annotated by BRENDA team
Stokke, R.; Madern, D.; Fedoy, A.; Karlsen, S.; Birkeland, N.; Steen, I.H.
Biochemical characterization of isocitrate dehydrogenase from Methylococcus capsulatus reveals a unique NAD+-dependent homotetrameric enzyme
Arch. Microbiol.
187
361-370
2007
Methylococcus capsulatus
Manually annotated by BRENDA team
Bzymek, K.P.; Colman, R.F.
Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase
Biochemistry
46
5391-5397
2007
Homo sapiens
Manually annotated by BRENDA team
Kanamasa, S.; Tajima, S.; Park, E.Y.
Isocitrate dehydrogenase and isocitrate lyase are essential enzymes for riboflavin production in Ashbya gossypii
Biotechnol. Bioprocess Eng.
12
92-99
2007
Eremothecium gossypii
-
Manually annotated by BRENDA team
Taylor, A.B.; Hu, G.; Hart, P.J.; McAlister-Henn, L.
Allosteric motions in structures of yeast NAD+-specific isocitrate dehydrogenase
J. Biol. Chem.
283
10872-10880
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lemaitre, T.; Urbanczyk-Wochniak, E.; Flesch, V.; Bismuth, E.; Fernie, A.R.; Hodges, M.
NAD-dependent isocitrate dehydrogenase mutants of Arabidopsis suggest the enzyme is not limiting for nitrogen assimilation
Plant Physiol.
144
1546-1558
2007
Arabidopsis thaliana (P93032), Arabidopsis thaliana (Q8LFC0), Arabidopsis thaliana (Q945K7)
Manually annotated by BRENDA team
Imada, K.; Tamura, T.; Takenaka, R.; Kobayashi, I.; Namba, K.; Inagaki, K.
Structure and quantum chemical analysis of NAD+-dependent isocitrate dehydrogenase: hydride transfer and co-factor specificity
Proteins
70
63-71
2008
Acidithiobacillus thiooxidans
Manually annotated by BRENDA team
Hatzopoulos, G.N.; Kefala, G.; Mueller-Dieckmann, J.
Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of isocitrate dehydrogenase 2 (Rv0066c) from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
64
1139-1142
2008
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Garcia, J.A.; Minard, K.I.; Lin, A.P.; McAlister-Henn, L.
Disulfide bond formation in yeast NAD+-specific isocitrate dehydrogenase
Biochemistry
48
8869-8878
2009
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Manually annotated by BRENDA team
Hartong, D.T.; Dange, M.; McGee, T.L.; Berson, E.L.; Dryja, T.P.; Colman, R.F.
Novel insights into the contributions of isocitrate dehydrogenases to the Krebs cycle from patients with retinitis pigmentosa
Nat. Genet.
40
1230-1234
2008
Homo sapiens (O43837)
Manually annotated by BRENDA team
Kang, M.R.; Kim, M.S.; Oh, J.E.; Kim, Y.R.; Song, S.Y.; Seo, S.I.; Lee, J.Y.; Yoo, N.J.; Lee, S.H.
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
Int. J. Cancer
125
353-355
2009
Homo sapiens
Manually annotated by BRENDA team
Dange, M.; Colman, R.F.
Each conserved active site tyr in the three subunits of human isocitrate dehydrogenase has a different function
J. Biol. Chem.
285
20520-20525
2010
Homo sapiens
Manually annotated by BRENDA team
Sienkiewicz-Porzucek, A.; Sulpice, R.; Osorio, S.; Krahnert, I.; Leisse, A.; Urbanczyk-Wochniak, E.; Hodges, M.; Fernie, A.R.; Nunes-Nesi, A.
Mild reductions in mitochondrial NAD-dependent isocitrate dehydrogenase activity result in altered nitrate assimilation and pigmentation but do not impact growth
Mol. Plant
3
156-173
2010
Solanum lycopersicum
Manually annotated by BRENDA team
Zhang, N.; Gur, A.; Gibon, Y.; Sulpice, R.; Flint-Garcia, S.; McMullen, M.D.; Stitt, M.; Buckler, E.S.
Genetic analysis of central carbon metabolism unveils an amino acid substitution that alters maize NAD-dependent isocitrate dehydrogenase activity
PLoS ONE
5
e9991
2010
Zea mays
Manually annotated by BRENDA team
Yang, F.; Zhang, S.; Zhou, Y.J.; Zhu, Z.; Lin, X.; Zhao, Z.K.
Characterization of the mitochondrial NAD+-dependent isocitrate dehydrogenase of the oleaginous yeast Rhodosporidium toruloides
Appl. Microbiol. Biotechnol.
94
1095-1105
2012
Rhodotorula toruloides (G1APK2), Rhodotorula toruloides (G1APK3), Rhodotorula toruloides, Rhodotorula toruloides AS 2.1389 (G1APK2), Rhodotorula toruloides AS 2.1389 (G1APK3)
Manually annotated by BRENDA team
McAlister-Henn, L.
Ligand binding and structural changes associated with allostery in yeast NAD+-specific isocitrate dehydrogenase
Arch. Biochem. Biophys.
519
112-117
2012
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Steen, I.H.; Lien, T.; Madsen, M.S.; Birkeland, N.K.
Identification of cofactor discrimination sites in NAD-isocitrate dehydrogenase from Pyrococcus furiosus
Arch. Microbiol.
178
297-300
2002
Pyrococcus furiosus (Q8U488), Pyrococcus furiosus
Manually annotated by BRENDA team
Lin, A.P.; McAlister-Henn, L.
Basis for half-site ligand binding in yeast NAD+-specific isocitrate dehydrogenase
Biochemistry
50
8241-8250
2011
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Wang, P.; Jin, M.; Zhu, G.
Biochemical and molecular characterization of NAD(+)-dependent isocitrate dehydrogenase from the ethanologenic bacterium Zymomonas mobilis
FEMS Microbiol. Lett.
327
134-141
2012
Zymomonas mobilis, Zymomonas mobilis ATCC 10988
Manually annotated by BRENDA team
Wang, P.; Song, P.; Jin, M.; Zhu, G.
Isocitrate dehydrogenase from Streptococcus mutans: biochemical properties and evaluation of a putative phosphorylation site at Ser102
PLoS ONE
8
e58918
2013
Streptococcus mutans
Manually annotated by BRENDA team
Steen, I.H.; Madern, D.; Karlström, M.; Lien, T.; Ladenstein, R.; Birkeland, N.K.
Comparison of isocitrate dehydrogenase from three hyperthermophiles reveals differences in thermostability, cofactor specificity, oligomeric state, and phylogenetic affiliation
J. Biol. Chem.
276
43924-43931
2001
Pyrococcus furiosus (Q8U488), Pyrococcus furiosus
Manually annotated by BRENDA team
Hagras, A.; Toraih, E.; Fawzy, M.
Mobile phones electromagnetic radiation and NAD
Biochim. Open
3
19-25
2016
Homo sapiens
Manually annotated by BRENDA team
Tang, W.G.; Song, P.; Cao, Z.Y.; Wang, P.; Zhu, G.P.
A unique homodimeric NAD+-linked isocitrate dehydrogenase from the smallest autotrophic eukaryote Ostreococcus tauri
FASEB J.
29
2462-2472
2015
Ostreococcus tauri
Manually annotated by BRENDA team
Wu, M.; Tian, C.; Cheng, H.; Xu, L.; Wang, P.; Zhu, G.
A novel type II NAD+-specific isocitrate dehydrogenase from the marine bacterium Congregibacter litoralis KT71
PLoS ONE
10
e0125229
2015
Congregibacter litoralis (A4ADB8), Congregibacter litoralis KT71 (A4ADB8), Congregibacter litoralis KT71
Manually annotated by BRENDA team
Yamada, S.; Kotake, Y.; Demizu, Y.; Kurihara, M.; Sekino, Y.; Kanda, Y.
NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells
Sci. Rep.
4
5952
2014
Homo sapiens (P50213), Homo sapiens
Manually annotated by BRENDA team
Wang, P.; Lv, C.; Zhu, G.
Novel type II and monomeric NAD+ specific isocitrate dehydrogenases: phylogenetic affinity, enzymatic characterization, and evolutionary implication
Sci. Rep.
5
9150
2015
Ostreococcus sp. 'lucimarinus', Ostreococcus sp. 'lucimarinus' (A4SBK5), Campylobacter curvus (A0A0M4S9Q1), Campylobacter curvus, Micromonas commoda (C1E5X2), Micromonas commoda, Campylobacter sp. (J4X756), Campylobacter curvus 525.92 (A0A0M4S9Q1), Campylobacter sp. FOBRC14 (J4X756), Micromonas commoda RCC299 (C1E5X2), Ostreococcus sp. 'lucimarinus' CCE9901, Ostreococcus sp. 'lucimarinus' CCE9901 (A4SBK5)
Manually annotated by BRENDA team
Yang, C.; Fan, J.; Zhuang, Z.; Fang, Y.; Zhang, Y.; Wang, S.
The role of NAD+-dependent isocitrate dehydrogenase 3 subunit alpha in AFB1 induced liver lesion
Toxicol. Lett.
224
371-379
2014
Homo sapiens (P50213), Rattus norvegicus (Q99NA5), Mus musculus (Q9D6R2)
Manually annotated by BRENDA team
Wang, P.; Chen, X.; Yang, J.; Pei, Y.; Bian, M.; Zhu, G.
Characterization of the nicotinamide adenine dinucleotides (NAD+ and NADP+) binding sites of the monomeric isocitrate dehydrogenases from Campylobacter species
Biochimie
160
148-155
2019
Campylobacter concisus, Campylobacter concisus DSM9716
Manually annotated by BRENDA team
Lv, P.; Tang, W.; Wang, P.; Cao, Z.; Zhu, G.
Enzymatic characterization and functional implication of two structurally different isocitrate dehydrogenases from Xylella fastidiosa
Biotechnol. Appl. Biochem.
65
230-237
2018
Xylella fastidiosa
Manually annotated by BRENDA team
Sun, P.; Liu, Y.; Ma, T.; Ding, J.
Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
Cell Discov.
6
94
2020
Homo sapiens (P50213 and O43837 and P51553), Homo sapiens
Manually annotated by BRENDA team
Huang, S.P.; Zhou, L.C.; Wen, B.; Wang, P.; Zhu, G.P.
Biochemical characterization and crystal structure of a novel NAD+-dependent isocitrate dehydrogenase from Phaeodactylum tricornutum
Int. J. Mol. Sci.
21
5915
2020
Phaeodactylum tricornutum, Phaeodactylum tricornutum FACHB-2174
Manually annotated by BRENDA team
Sun, P.; Ma, T.; Zhang, T.; Zhu, H.; Zhang, J.; Liu, Y.; Ding, J.
Molecular basis for the function of the alphabeta heterodimer of human NAD-dependent isocitrate dehydrogenase
J. Biol. Chem.
294
16214-16227
2019
Homo sapiens (P50213 and O43837), Homo sapiens
Manually annotated by BRENDA team
Giordana, L.; Nowicki, C.
Two phylogenetically divergent isocitrate dehydrogenases are encoded in Leishmania parasites. Molecular and functional characterization of Leishmania mexicana isoenzymes with specificity towards NAD+ and NADP+
Mol. Biochem. Parasitol.
240
111320
2020
Leishmania mexicana
Manually annotated by BRENDA team
Romkina, A.; Kiriukhin, M.
Biochemical and molecular characterization of the isocitrate dehydrogenase with dual coenzyme specificity from the obligate methylotroph Methylobacillus flagellatus
PLoS ONE
12
e0176056
2017
Methylobacillus flagellatus, Methylobacillus flagellatus ATCC51484
Manually annotated by BRENDA team
Armingol, E.; Tobar, E.; Cabrera, R.
Understanding the impact of the cofactor swapping of isocitrate dehydrogenase over the growth phenotype of Escherichia coli on acetate by using constraint-based modeling
PLoS ONE
13
e0196182
2018
Escherichia coli
Manually annotated by BRENDA team
Wang, X.; Inaoka, D.K.; Shiba, T.; Balogun, E.O.; Allmann, S.; Watanabe, Y.I.; Boshart, M.; Kita, K.; Harada, S.
Expression, purification, and crystallization of type 1 isocitrate dehydrogenase from Trypanosoma brucei
Protein Expr. Purif.
138
56-62
2017
Trypanosoma brucei brucei, Trypanosoma brucei brucei ILtat 1.4
Manually annotated by BRENDA team
Sun, P.; Bai, T.; Ma, T.; Ding, J.
Molecular mechanism of the dual regulatory roles of ATP on the alphagamma heterodimer of human NAD-dependent isocitrate dehydrogenase
Sci. Rep.
10
6225
2020
Homo sapiens (P50213 and O43837 and P51553), Homo sapiens
Manually annotated by BRENDA team
Ma, T.; Peng, Y.; Huang, W.; Ding, J.
Molecular mechanism of the allosteric regulation of the alphagamma heterodimer of human NAD-dependent isocitrate dehydrogenase
Sci. Rep.
7
40921
2017
Homo sapiens (P50213 and O43837 and P51553), Homo sapiens
Manually annotated by BRENDA team
Liu, Y.; Hu, L.; Ma, T.; Yang, J.; Ding, J.
Insights into the inhibitory mechanisms of NADH on the alphagamma heterodimer of human NAD-dependent isocitrate dehydrogenase
Sci. Rep.
8
3146
2018
Homo sapiens (P50213 and O43837 and P51553), Homo sapiens
Manually annotated by BRENDA team