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1.1.1.41: isocitrate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about isocitrate dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.41

Reaction

isocitrate
+
NAD+
=
2-oxoglutarate
 +
CO2
 +
NADH
 +
H+

Synonyms

At2g17130, At4g35260, At4g35650, At5g03290, AtIDH I, AtIDH II, AtIDH V, AtIDH VI, beta-decarboxylating dehydrogenase, beta-ketoglutaric-isocitric carboxylase, CaIDH, CcIDH, hNAD-IDHalpha, homodimeric NAD+-linked isocitrate dehydrogenase, Icd-2, ICDH, ICDH1, IDH, IDH I, IDH II, IDH III, IDH IV, IDH V, IDH-50, IDH-I, IDH-II, IDH-V, IDH1, IDH2, IDH3, IDH3A, IDH3alpha, IDH5, IDHa, isocitrate dehydrogenase, isocitrate dehydrogenase 2, isocitrate dehydrogenase 3alpha subunit, isocitrate-homoisocitrate dehydrogenase, isocitric acid dehydrogenase, isocitric dehydrogenase, McIDH, mIDH, MiIDH, mitochondrial NAD-dependent isocitrate dehydrogenase, monomeric NAD-IDH, NAD dependent isocitrate dehydrogenase, NAD isocitrate dehydrogenase, NAD isocitric dehydrogenase, NAD(P)+-dependent isocitrate dehydrogenase, NAD+-dependent ICDH, NAD+-dependent IDH, NAD+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase 1, NAD+-dependent isocitrate dehydrogenase 3, NAD+-dependent type 1 IDH, NAD+-IDH, NAD+-specific ICDH, NAD+-specific IDH, NAD+-specific isocitrate dehydrogenase, NAD-Dependent IDH, NAD-dependent isocitrate dehydrogenase, NAD-ICDH, NAD-IDH, NAD-isocitrate dehydrogenase, NAD-linked isocitrate dehydrogenase, NAD-specific isocitrate dehydrogenase, NADH-IDH, OlIDH, OtIDH, PF0202, PH1722, Rv0066c, threo-DS-isocitrate:NAD+ oxidoreductase (decarboxylating), type 1 isocitrate dehydrogenase, type II homodimeric NAD-IDH, type II NAD+-specific isocitrate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.41 isocitrate dehydrogenase (NAD+)

Inhibitors

Inhibitors on EC 1.1.1.41 - isocitrate dehydrogenase (NAD+)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
130-nucleotide transcript containing the 5'-untranslated regions of the yeast mitochondrial COX2 mRNA
-
inhibition with a 50% reduction in activity observed with 40 nM mRNA
-
2-hydroxyethylamine-N,N-diacetate
-
-
2-oxoglutarate
2-Oxopropane-1,1,3-tricarboxylate
-
only in presence of ADP
beta-mercapto-alpha-ketoglutarate
-
inhibition in presence and absence of AMP, competitive inhibition
bilirubin
-
-
Chicago sky blue
-
-
cis-aconitate
-
91% residual activity at 2 mM
citrate
Congo red
-
-
D,L-hibiscusate
-
with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, D,L-hibiscusate is an activator
D,L-threo-alpha-methylisocitrate
-
inhibition in presence and absence of AMP, competitive inhibition
D-malate
-
inhibition only in absence of AMP
D-Tartrate
-
inhibition only in absence of AMP
Diamide
EDTA
-
-
EGTA
-
-
fluorescein
-
halogenated derivatives
Fluorocitrate
-
with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, fluorocitrate is an activator
fumarate
gamma-aminobutyric acid
-
slight inhibition
glutamate
-
slight inhibition
glyoxylate
homocitrate
-
inhibition only in absence of AMP
L-garciniate
-
inhibition in presence and absence of AMP
L-glutamate
L-glutamine
-
96% residual activity at 2 mM
L-hibiscusate
-
with constant concentrations of isocitrate, NAD+ and Mg2+ up to 10 mM and without AMP, L-hibiscusate is an activator
L-malate
-
inhibition only in absence of AMP, competitive inhibition
L-Tartrate
-
inhibition only in absence of AMP
Li+
-
5.15% residual activity at 2 mM
Maleate
-
inhibition only in absence of AMP
malonate
-
inhibition only in absence of AMP
Mg2+
-
free form
mitochondrial COX2 UTR RNA
-
-
-
molybdate
mRNA
-
enzyme specifically binds to 5'-untranslated regions of yeast mitochondrial mRNAs, and transcripts containing these regions allosterically inhibit the enzyme, which can be relieved by activator AMP in presence of isocitrate, complex formation, overview
NADPH
nitrilotriacetate
-
-
oxaloacetate
p-hydroxymercuribenzoate
-
-
pyruvate
-
with oxaloacetate, concomitantly added, less effective than glyoxylate + oxaloacetate
succinate
Succinic semialdehyde
Sulfobromophthalein
-
-
thiocyanate
-
-
tributyltin
TBT, active in NT2/D1 carcinoma cells, overview. At nanomoler concentrations, tributyltin actions are mediated by genomic pathways via peroxisome proliferator-activated receptor gamma/retinoid X receptor, PPAR/RXR. Binding and in silico docking simulation analysis, overview
additional information
-