1.1.1.391: 3beta-hydroxycholanate 3-dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about 3beta-hydroxycholanate 3-dehydrogenase (NAD+), go to the full flat file.
Reaction
Synonyms
3beta-HSD, 3beta-HSDH, 3beta-hydroxysteroid dehydrogenase, bile acid 3beta-HSD, iso bile acid dehydrogenase, NAD-dependent 3beta-hydroxysteroid dehydrogenase
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.1.1.391 - 3beta-hydroxycholanate 3-dehydrogenase (NAD+)
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REACTION DIAGRAM
12alpha-hydroxy-3-oxo-5-beta-cholan-24-oic acid + NADH + H+
3beta,12alpha-dihydroxy-5-beta-cholan-24-oic acid + NAD+
3,12-dioxo-5-beta-cholan-24-oic acid + NADH + H+
3beta-hydroxy-12-oxo-5beta-cholan-24-oic acid + NAD+
3beta,7beta-dihydroxy-5beta-cholan-24-oic acid + NAD+
7beta-hydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+
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substrate docking of isoursodeoxycholic acid to the active site of a three-dimensional model of human class I gammagamma alcohol dehydrogenase reveals that the ADH gammagamma isozyme is the iso bile acid 3beta-hydroxysteroid dehydrogenase present in human liver cytosol, with NAD+ as a cofactor, but ethanol is the preferred substrate
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7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+
3beta,7alpha,12alpha-trihydroxy-5beta-cholan-24-oic acid + NAD+
3beta,12alpha-dihydroxy-5-beta-cholan-24-oic acid + NAD+
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12alpha-hydroxy-3-oxo-5-beta-cholan-24-oic acid + NADH + H+
3beta,12alpha-dihydroxy-5-beta-cholan-24-oic acid + NAD+
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3beta-hydroxy-12-oxo-5beta-cholan-24-oic acid + NAD+
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3,12-dioxo-5-beta-cholan-24-oic acid + NADH + H+
3beta-hydroxy-12-oxo-5beta-cholan-24-oic acid + NAD+
[Clostridium] innocuum D1144/3
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3beta,7alpha,12alpha-trihydroxy-5beta-cholan-24-oic acid + NAD+
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7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+
3beta,7alpha,12alpha-trihydroxy-5beta-cholan-24-oic acid + NAD+
[Clostridium] innocuum D1144/3
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