1.1.1.379: (R)-mandelate dehydrogenase

This is an abbreviated version!
For detailed information about (R)-mandelate dehydrogenase, go to the full flat file.

Reaction

Synonyms

D(-)-mandelate dehydrogenase, D-mandelate dehydrogenase, D-ManDH, D-ManDH2, DMDH, LhDMDH, ManDH2, NAD+-dependent D-mandelate dehydrogenase, NAD-dependent D-mandelate dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.379 (R)-mandelate dehydrogenase

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Results	in table
2	AA Sequence
1	Application
2	Cloned(Commentary)
5	Cofactor
2	Crystallization (Commentary)
2	General Information
23	Inhibitors
2	kcat/KM [mM/s]
3	Ki Value [mM]
13	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
6	Organism
6	pH Optimum
4	pH Stability
1	pI Value
1	Protein Variants
3	Purification (Commentary)
1	Reaction
6	Reference
2	Specific Activity [micromol/min/mg]
15	Substrates and Products (Substrate)
4	Subunits
13	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.1.1.379 - (R)-mandelate dehydrogenase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(R)-mandelate + NAD+

phenylglyoxylate + NADH + H+

5 entries

2-oxocaproate + NADH + H+

? + NAD+

Enterococcus faecium

-

-

762694

-

-

?

2-oxoisovalerate + NADH + H+

? + NAD+

Enterococcus faecium

-

-

762694

-

-

?

2-oxopantoate + NADH + H+

? + NAD+

Enterococcus faecium

-

-

762694

-

-

?

anilino(oxo)acetate + NADH + H+

anilino(hydroxy)acetate + NAD+

Enterococcus faecium

-

AOA

762694

-

-

?

phenylglyoxylate + NADH + H+

(R)-mandelate + NAD+

3 entries

phenylpyruvate + NADH + H+

? + NAD+

Enterococcus faecium

-

-

762694

-

-

?

additional information

?

-

2 entries

(R)-mandelate + NAD+

phenylglyoxylate + NADH + H+

Rhodotorula graminis

Q7LLW9

first enzyme of the mandelate pathway in the yeast Rhodotorula graminis

729156

-

-

?

(R)-mandelate + NAD+

phenylglyoxylate + NADH + H+

Rhodotorula graminis

Q7LLW9

equilibrium constant is 1.59 x 10(-11) M, pH 9.2

730341

-

-

r

(R)-mandelate + NAD+

phenylglyoxylate + NADH + H+

Rhodotorula graminis

Q7LLW9

the enzyme transfers the pro-R hydrogen atom from NADH during the reduction of phenylglyoxylate

729156

-

-

?

(R)-mandelate + NAD+

phenylglyoxylate + NADH + H+

Rhodotorula graminis KGX 39

Q7LLW9

equilibrium constant is 1.59 x 10(-11) M, pH 9.2

730341

-

-

r

(R)-mandelate + NAD+

phenylglyoxylate + NADH + H+

Schleiferilactobacillus harbinensis

A0A5P8Q188

-

763170

-

-

r

phenylglyoxylate + NADH + H+

(R)-mandelate + NAD+

Enterococcus faecium

-

-

762694

-

-

?

phenylglyoxylate + NADH + H+

(R)-mandelate + NAD+

Enterococcus faecium

-

i.e. benzoylformate

762694

-

-

?

phenylglyoxylate + NADH + H+

(R)-mandelate + NAD+

Schleiferilactobacillus harbinensis

A0A5P8Q188

-

763170

-

-

r

additional information

?

-

Enterococcus faecium

-

the enzyme exhibits broad substrate specificity toward bulky hydrophobic 2-ketoacids, preferring C3-branched substrates

762694

-

-

-

additional information

?

-

Schleiferilactobacillus harbinensis

A0A5P8Q188

D-2-chloromandelic acid and L-mandelic acid are poor substrates, while L-2-chloromandelic acid and L-lactic acid are no substrates for enzyme LhDMDH

763170

-

-

-