1.1.1.367: UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase
This is an abbreviated version!
For detailed information about UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase, go to the full flat file.
Reaction
Synonyms
Cap5F, CapF, capsular polysaccharide synthesis enzyme, O11 O-antigen biosynthesis associated epimerase, WbjC
ECTree
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Engineering
Engineering on EC 1.1.1.367 - UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase
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F297Y
mutation in the second co-ordination sphere of Zn2+, mutant exerts a minor effect on catalytic activity
H290L
mutation in he coordination sphere of Zn2+. Mutant maintains a native-like dimeric conformation in solution, but does not generate a final product
S94A/Y103A
catalytic site of the short-chain dehydrogenase/reductase domain. Mutant maintains a native-like dimeric conformation in solution, but does not generate a final product. Addition of the reductase domain rescue the enzymatic activity
T364Y F297Y
mutation in the second co-ordination sphere of Zn2+, mutant exerts a minor effect on catalytic activity
F297Y
-
mutation in the second co-ordination sphere of Zn2+, mutant exerts a minor effect on catalytic activity
-
H290L
-
mutation in he coordination sphere of Zn2+. Mutant maintains a native-like dimeric conformation in solution, but does not generate a final product
-
S94A/Y103A
-
catalytic site of the short-chain dehydrogenase/reductase domain. Mutant maintains a native-like dimeric conformation in solution, but does not generate a final product. Addition of the reductase domain rescue the enzymatic activity
-
T364Y F297Y
-
mutation in the second co-ordination sphere of Zn2+, mutant exerts a minor effect on catalytic activity
-