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1.1.1.357: 3alpha-hydroxysteroid 3-dehydrogenase

This is an abbreviated version!
For detailed information about 3alpha-hydroxysteroid 3-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.357

Reaction

a 3alpha-hydroxysteroid
+
NAD(P)+
=
a 3-oxosteroid
+
NAD(P)H
+
H+

Synonyms

17beta-HSD5, 3-alpha hydroxysteroid dehydrogenase type 3, 3-alpha-HSD type 2, 3-alpha-HSD1, 3-alpha-hydroxysteroid dehydrogenase type 2, 3-alpha-hydroxysteroid dehydrogenase type I, 3alpha-HSD, 3alpha-HSD type III, 3alpha-HSD/CR, 3alpha-HSD3, 3alpha-HSOR, 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase type 3, 3alpha-hydroxysteroid dehydrogenase type III, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxidoreductase, AKR1C1, AKR1C14, AKR1C2, AKR1C3, AKR1C33, AKR1C4, AKR1C9, aldo-keto reductase family 1 member C1, aldo-keto reductase family 1 member C2, aldo-keto reductase family 1 member C3, bile acid binding protein, chlordecone reductase, DD2, DD4, dihydrodiol dehydrogenase, dihydrodiol dehydrogenase 4, dihydrodiol/3alpha-hydroxysteroid dehydrogenase, HSD 28, HSD 29, hsdA, More, NADPH-dependent AKR1C9, Naloxone reductase 2, Ps3alphaHSD, type 1 3alpha-HSD, type 3 3alpha-hydroxysteroid dehydrogenase, type 5 17beta-hydroxysteroid dehydrogenase, type I 3alpha-HSD, type III 3-alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase

KM Value

KM Value on EC 1.1.1.357 - 3alpha-hydroxysteroid 3-dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.16 - 0.68
(R)-tetralol
0.14 - 0.26
(S)-1,2,3,4-tetrahydronaphth-1-ol
0.146 - 0.52
(S)-indan-1-ol
0.11 - 0.29
(S)-tetralol
1
2-(1-imidazolyl)-1-(4-methoxyphenyl)-2-methyl-1-propanone
pH 7.0, temperature not specified in the publication, NAD(P)H
0.16 - 1.7
2-decalol
0.025 - 0.028
3-dehydro-alpha-ecdysone
0.035
3-dehydro-beta-ecdysone
pH 7.0, temperature not specified in the publication, NAD(P)H
0.0105
3alpha-androstanediol
isoform AKR1C4, at pH 7.4 and 25°C
0.0152 - 0.0216
3alpha-hydroxydesogestrel
0.00212
4-androstenedione
pH 7.4, 37°C
0.0023 - 0.03362
4-hydroxyandrostenedione
-
0.00603 - 0.02687
4-hydroxytestosterone
-
0.9 - 1
4-Nitroacetophenone
1 - 1.09
4-nitrobenzaldehyde
0.0001 - 0.003
5alpha-androstan-17-beta-ol-3-one
0.002 - 0.0022
5alpha-Androstan-3alpha-ol-17-one
0.00144
5alpha-androstane-3,17-dione
isoform AKR1C4, at pH 7.4 and 25°C
0.0008 - 0.0031
5alpha-androstane-3alpha,17beta-diol
0.0018
5alpha-dihydroprogesterone
in 100 mM potassium phosphate, pH 7.0, at 25°C
0.0012 - 0.07103
5alpha-dihydrotestosterone
0.0002 - 0.0003
5alpha-pregnan-20alpha-ol-3-one
0.0006 - 0.003
5beta-androstan-3,17-dione
0.0006 - 0.0021
5beta-Androstan-3alpha-ol-17-one
0.0012 - 0.0022
5beta-androstane-3alpha,17beta-diol
0.0111 - 0.0201
5beta-dihydrotestosterone
0.0005 - 0.0023
5beta-pregnane-3,20-dione
0.001
5beta-pregnane-3alpha,20alpha-diol
0.208 - 0.22
9alpha,11beta-prostaglandin F2
0.0015
allopregnanolone
in 100 mM potassium phosphate, pH 7.0, at 25°C
0.0328
androstandiol
pH 8.9, temperature not specified in the publication, NAD(P)+
0.0357
androstandione
pH 7.0, temperature not specified in the publication, NAD(P)H
0.0012
androstenol
reombinant His-tagged enzyme, pH 10.5, 25°C
0.0005 - 14
androsterone
0.0011 - 0.0029
chenodeoxycholic acid
0.025 - 586
cholic acid
27 - 48
Cyclohexanol
51 - 2489
Dehydrocholic acid
0.0009 - 0.004
Dehydrolithocholic acid
0.0013 - 0.0097
deoxycholic acid
0.0011 - 0.016
dihydrotestosterone
0.0207
epiandrosterone
pH 8.9, temperature not specified in the publication, NAD(P)+
0.003 - 0.0068
Fusidic acid
0.001 - 0.0019
lithocholic acid
2.1
metyrapol
pH 8.9, temperature not specified in the publication, NAD(P)+
0.61 - 0.63
Metyrapone
0.081 - 1.2
NAD+
0.033
NADH
mutant F217S, pH 7.4, 25°C
0.0002 - 0.017
NADP+
0.00007 - 0.009
NADPH
0.00084 - 0.00213
pregn-4-en-3,20-dione
additional information
additional information
-