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1.1.1.351: phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]

This is an abbreviated version!
For detailed information about phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating], go to the full flat file.

Reaction

6-phospho-D-gluconate
+
NAD(P)+
=
D-ribulose 5-phosphate
+
CO2
+
NAD(P)H
+
H+

Synonyms

6-phospho-D-gluconate dehydrogenase (decarboxylating), 6-phospho-D-gluconate:NADP+ 2-oxidoreductase, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (NADP+/NAD+), 6PGDH, gnd

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.351 phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]

Systematic Name

Systematic Name on EC 1.1.1.351 - phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]

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SYSTEMATIC NAME
IUBMB Comments
6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase (decarboxylating)
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce reducing power and pentose for biosynthetic reactions. Unlike EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), it is not specific for NADP+ and can accept both cofactors with similar efficiency. cf. EC 1.1.1.343, phosphogluconate dehydrogenase [NAD+-dependent, decarboxylating].