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1.1.1.350: ureidoglycolate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about ureidoglycolate dehydrogenase (NAD+), go to the full flat file.

Reaction

(S)-ureidoglycolate
+
NAD+
=
N-carbamoyl-2-oxoglycine
+
NADH
+
H+

Synonyms

(S)-ureidoglycolate dehydrogenase, AllD, ureidoglycolate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.350 ureidoglycolate dehydrogenase (NAD+)

Engineering

Engineering on EC 1.1.1.350 - ureidoglycolate dehydrogenase (NAD+)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D141A
the mutant shows strongly reduced catalytic efficiency compared to the wild type enzyme
D141E
the mutant shows strongly reduced catalytic efficiency compared to the wild type enzyme
D141N
the mutant shows strongly reduced catalytic efficiency compared to the wild type enzyme
H44A
the mutant shows strongly reduced catalytic efficiency compared to the wild type enzyme
M251A
the mutant shows strongly reduced catalytic efficiency compared to the wild type enzyme
R259A
in the mutant enzyme R259A, the kcat value is approximately 21% that of the wild type enzyme, with about an 11fold increase in Km
S140A
the mutant shows strongly reduced catalytic efficiency compared to the wild type enzyme
S43A
the mutant shows strongly reduced catalytic efficiency compared to the wild type enzyme
Y52F
the mutant shows strongly reduced catalytic efficiency compared to the wild type enzyme