Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.1.34: hydroxymethylglutaryl-CoA reductase (NADPH)

This is an abbreviated version!
For detailed information about hydroxymethylglutaryl-CoA reductase (NADPH), go to the full flat file.

Word Map on EC 1.1.1.34

Reaction

(R)-mevalonate
+
CoA
+ 2 NADP+ =
(S)-3-hydroxy-3-methylglutaryl-CoA
+ 2 NADPH + 2 H+

Synonyms

3-hydroxy-3-methyl-glutaryl CoA reductase, 3-hydroxy-3-methylglutaryl Ccoenzyme A reductase 1, 3-hydroxy-3-methylglutaryl co-enzyme A reductase, 3-hydroxy-3-methylglutaryl CoA reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase 1, 3-hydroxy-3-methylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-CoA reductase (NADPH), 3-hydroxy-3-methylglutaryl-CoA reductase 1, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase 5, 3-hydroxy-3-metylglutaryl coenzyme A reductase, 3-hydroxymethylglutaryl coenzyme A reductase, acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl-Co A reductase, EuHMGR, HMG CoA reductase, HMG-CoA reductase, HMG-CoA-R, HMG-CoAR, HMG1, HMG2, HMG2.2, Hmg2p, HMG3.3, HMGCoA reductase, HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating CoA), HMGCoAR, HMGCR, HMGCR1, HMGR, HMGR1, HMGR1S, HMGR2, HMGR3, HMGR5, hydroxy-3-methylglutoryl-Coenzyme A reductase, hydroxymethylglutaryl CoA reductase (NADPH), hydroxymethylglutaryl-coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate), mevalonate:NADP+ oxidoreductase (acetylating CoA), microsomal HMG-CoA reductase, NADPH-hydroxymethylglutaryl-CoA reductase, S-3-hydroxy-3-methylglutaryl-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)

Substrates Products

Substrates Products on EC 1.1.1.34 - hydroxymethylglutaryl-CoA reductase (NADPH)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-mevaldehyde + NADPH + H+
(R)-mevalonate + NADP+
show the reaction diagram
(R)-mevalonate + CoA + 2 NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
show the reaction diagram
(R)-mevalonate + CoA + NADP+
(S)-3-hydroxy-3-methylglutaryl-CoA + NADPH + H+
show the reaction diagram
-
-
-
-
r
(R,S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
(R)-mevalonate + CoA + 2 NADP+
show the reaction diagram
(R,S)-mevaldehyde + acetate
?
show the reaction diagram
-
-
-
-
?
(R,S)-mevaldehyde + NADPH
?
show the reaction diagram
-
-
-
-
?
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
(R)-mevalonate + 2 NADP+ + CoA
show the reaction diagram
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
(R)-mevalonate + CoA + 2 NADP+
show the reaction diagram
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
mevalonate + CoA + 2 NADP+
show the reaction diagram
-
-
-
-
r
(S)-3-hydroxy-3-methylglutaryl-CoA + NADPH + H+
mevaldehyde + CoA + NADP+
show the reaction diagram
-
first step reaction
-
-
r
(S)-3-hydroxy-3-methylglutaryl-CoA + NADPH + H+
mevaldyl-CoA + NADP+
show the reaction diagram
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
mevalonate + CoA + 2 NADP+
show the reaction diagram
3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
mevalonolactone + CoA + 2 NADP+ + H2O
show the reaction diagram
3-hydroxy-3-methylglutaryl-CoA + NADPH
(R)-mevalonate + CoA + NADP+
show the reaction diagram
3-hydroxy-3-methylglutaryl-CoA + NADPH
mevalonate + CoA + NADP+
show the reaction diagram
3-hydroxy-3-methylglutaryl-CoA + NADPH + H+
mevalonate + CoA + NADP+
show the reaction diagram
-
-
-
-
?
acetyl-CoA
acetoacetyl-CoA + CoA
show the reaction diagram
-
-
-
-
r
D-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
(R)-mevalonate + CoA + 2 NADP+
show the reaction diagram
-
-
-
-
r
D-3-hydroxy-3-methylglutaryl-CoA + NADPH
mevalonate + CoA + NADP+
show the reaction diagram
DL-3-hydroxy-3-methylglutaryl-CoA + NADPH
mevalonate + CoA + NADP+
show the reaction diagram
-
-
-
-
?
hydroxymethylglutaryl-CoA + NADPH + H+
mevalonate + NADP+ + CoA
show the reaction diagram
mevaldehyde + NADPH + H+
(R)-mevalonate + NADP+
show the reaction diagram
mevaldyl-CoA + H2O
mevaldehyde + NADP+
show the reaction diagram
-
second step reaction
-
-
r
mevaldyl-CoA + NADPH + H+ + H2O
(R)-mevalonate + CoA + NADP+
show the reaction diagram
-
second step reaction
-
-
?
additional information
?
-