1.1.1.317: perakine reductase
This is an abbreviated version!
For detailed information about perakine reductase, go to the full flat file.
Reaction
Synonyms
AKR13D1
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.317 - perakine reductase
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REACTION DIAGRAM
4-nitroacetophenone + NADPH + H+
4-nitrobenzylalcohol + NADP+
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4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzoate + NADP+
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perakine + NADPH + H+
raucaffrinoline + NADP+
the biosynthesis of raucaffrinoline from perakine is a side route of the ajmaline biosynthesis pathway (monoterpenoid indole alkaloid)
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perakine + NADPH + H+
raucaffrinoline + NADP+
NADPH can not be replaced by NADH. In presence of the oxidized cofactor NADP+ the reverse reaction of the reductase is low, with less than 0.5% relative activity of the forward reaction
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probable dual functionality of perakine reductase, which may not only include alkaloid biosynthesis but may also include function in phenylpropanoid metabolism, generating cinnamic alcohols
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additional information
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the enzyme also catalyses the reduction of coniferyl aldehyde, sinapyl aldehyde, 4-coumaryl aldehyde, 3-(3,4,5-trimethoxyphenyl)propenal
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additional information
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the enzyme also catalyses the reduction of coniferyl aldehyde, sinapyl aldehyde, 4-coumaryl aldehyde, 3-(3,4,5-trimethoxyphenyl)propenal
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additional information
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enantioselective 1,2-reduction of alpha,beta-unsaturated ketones and aryl ketones by perakine reductase. Perakine reductase catalyzes asymmetric reduction of enones and aromatic ketones, leading to alpha-allylic alcohols and alpha-aromatic alcohols. It is NADPH-dependent. Among the evaluated substances, 4'-nitroacetophenone is found to be the best ketone substrate, with yield and enantiomeric excess values exceeding 99%. Exclusive enantioselectivity of enzyme perakine reductase (PR)
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