1.1.1.283: methylglyoxal reductase (NADPH)

This is an abbreviated version!
For detailed information about methylglyoxal reductase (NADPH), go to the full flat file.

Reaction

Synonyms

AKR, aldo-keto reductase, AlrA, CaGre2, CANTEDRAFT_112488, D-lactaldehyde dehydrogenase, EC 1.1.1.78, Gre2, GRE2 gene product, GRE2/YOL151W, Gre2p, GRE3, GRP2, Lbuc_0522, MeGR, Mer, methylglyoxal reductase, methylglyoxal reductase (NADPH dependent), methylglyoxal/isovaleraldehyde reductase, MG reductase, MG-specific aldolase reductase, MGR, More, NADPH-dependent methylglyoxal reductase, NADPH-linked aldolase reductase, PAS_chr3_0744, SakR1, YGL039w1, YGL039w2, YOL151W, YOL151w gene product

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.283 methylglyoxal reductase (NADPH)

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Results	in table
10	Activating Compound
316	AA Sequence
1	Application
1	CAS Registry Number
13	Cloned(Commentary)
30	Cofactor
4	Crystallization (Commentary)
112	General Information
28	Inhibitors
2	kcat/KM [mM/s]
29	KM Value [mM]
27	Localization
1	Metals/Ions
8	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
59	Organism
7	Pathway
6	PDB ID
5	pH Optimum
1	pH Stability
1	Posttranslational Modification
4	Protein Variants
5	Purification (Commentary)
5	Reaction
51	Reference
1	Source Tissue
39	Specific Activity [micromol/min/mg]
2	Storage Stability
103	Substrates and Products (Substrate)
5	Subunits
128	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Temperature Stability [°C]
17	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.1.1.283 - methylglyoxal reductase (NADPH)

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SYSTEMATIC NAME

IUBMB Comments

(S)-lactaldehyde:NADP+ oxidoreductase

The enzyme from the yeast Saccharomyces cerevisiae catalyses the reduction of a keto group in a number of compounds, forming enantiopure products. Among the substrates are methylglyoxal (which is reduced to (S)-lactaldehyde) [1,2], 3-methylbutanal [3], hexane-2,5-dione [4] and 3-chloro-1-phenylpropan-1-one [5]. The enzyme differs from EC 1.1.1.78, methylglyoxal reductase (NADH), which is found in mammals, by its coenzyme requirement, reaction direction, and enantiomeric preference.